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Pena-Shokeir phenotype/fetal akinesia deformation sequence: From placenta to secondary myopathy
Objectives: The etiologies of Pena-Shokeir phenotype (PSP), or fetal akinesia deformation sequence, include many genetic and acquired disorders, including the poor uteroplacental perfusion.
Source: Placenta - August 29, 2014 Category: Reproduction Medicine Authors: Dehua Wang, Robert J. Hopkin, Emily King, Maria A. Calvo-Garcia, Jerzy Stanek Tags: Frontmatter Source Type: research

Mitochondria: Role of citrulline and arginine supplementation in MELAS syndrome.
Abstract Mitochondria are found in all nucleated human cells and generate most of the cellular energy. Mitochondrial disorders result from dysfunctional mitochondria that are unable to generate sufficient ATP to meet the energy needs of various organs. Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a frequent maternally inherited mitochondrial disorder. There is growing evidence that nitric oxide (NO) deficiency occurs in MELAS syndrome and results in impaired blood perfusion that contributes significantly to several complications including stroke-like episodes, myop...
Source: The International Journal of Biochemistry and Cell Biology - January 8, 2014 Category: Biochemistry Authors: El-Hattab AW, Emrick LT, Chanprasert S, Craigen WJ, Scaglia F Tags: Int J Biochem Cell Biol Source Type: research

Postanesthetic Neuropathy/Myopathy in the Nondependent Forelimb in 4 Horses
Abstract: Postanesthetic lameness in the form of myopathy or neuropathy is a well-known complication associated with equine general anesthesia and is most often reported in the dependent limb of horses treated in lateral recumbency. The aim of this case series was to report clinical data of 4 horses treated under general anesthesia in lateral recumbency and that developed postanesthetic neuropathy/myopathy in the nondependent forelimb. With anti-inflammatory and analgesic medical treatment, locomotor problems associated with neuropathy/myopathy resolved after 12–24 hours in all cases. The pathogenesis remains unclear. A ...
Source: Journal of Equine Veterinary Science - April 22, 2013 Category: Veterinary Research Authors: Maarten Oosterlinck, Stijn Schauvliege, Ann Martens, Frederik Pille Tags: Original Research Source Type: research

Detection of Presymptomatically Latent Lesions Developing into Stroke-Like Episodes by Arterial Spin-Labeling Perfusion MRI in MELAS Patients (P03.162)
CONCLUSIONS: These findings suggest that regional ASL hyperperfusion in the presymptomatic phase precedes the appearance of upcoming stroke-like lesions, and that presymptomatic SEs had already occurred several months before the onset of clinical symptoms. ASL imaging has great potential for detecting presymptomatic stroke-like lesions and predicting the emergence of SEs.Supported by: In part by Grants-in-Aid for the Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Young Scientists (B) from the Japan Society for the Promotion of Science, and the Re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ikawa, M., Kimura, H., Muramatsu, T., Matsunaga, A., Tsujikawa, T., Yamamoto, T., Kosaka, N., Kinoshita, K., Yamamura, O., Hamano, T., Nakamoto, Y., Yoneda, M. Tags: P03 Cerebrovascular Disease III Source Type: research

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