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Procedure: Anesthesia

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Total 115 results found since Jan 2013.

Neuromuscular blocking effects of vecuronium in dogs with autosomal-recessive centronuclear myopathy.
CONCLUSIONS AND CLINICAL RELEVANCE For the study dogs, neither potency nor duration of vecuronium-induced neuromuscular blockade was altered by CNM. Vecuronium can be used to induce neuromuscular blockade in dogs with autosomal-recessive CNM. PMID: 25815571 [PubMed - in process]
Source: American Journal of Veterinary Research - April 1, 2015 Category: Veterinary Research Authors: Martin-Flores M, Paré MD, Tomak EA, Corn ML, Campoy L Tags: Am J Vet Res Source Type: research

Mitochondria DNA Depletion Syndrome in a Infant with Multiple Congenital Malformations, Severe Myopathy, and Prolonged Postoperative Paralysis
We describe a newborn with multiple congenital malformations including a right aberrant subclavian artery and a trachea-oesophageal fistula in whom mitochondrial depletion syndrome was unmasked by perioperative muscle relaxation. After vecuronium infusion, the infant developed an irreversible postoperative paralysis, leading to death 32 days after surgery. The present case highlights (a) the clinical heterogeneity of mitochondrial depletion syndrome; (b) the importance of rigorous antemortem and postmortem investigations when the cause of a severe myopathy is uncertain; (c) the possible coexistence of mitochondrial depleti...
Source: Journal of Child Neurology - March 23, 2015 Category: Neurology Authors: Thomas, M., Salpietro, V., Canham, N., Ruggieri, M., Phadke, R., Kinali, M. Tags: Brief Communication Source Type: research

General Anesthesia for Adults with Mitochondrial Myopathy
We report the case of a 59-year-old woman with mitochondrial myopathy who underwent elective laparoscopic cholecystectomy and hemorrhoidectomy, and we review the literature discussing general anesthesia for adults with mitochondrial myopathy. Our management technique avoids neuromuscular-blocking drugs and uses a modified awake intubation method not previously described in such patients. We hope to improve patient safety by discussing evidence-based anesthetic concerns and complications specific to these uncommon patients and aid practitioners in devising a suitable anesthetic plan.
Source: A&A Case Reports - March 1, 2015 Category: Anesthesiology Tags: Case Reports: Case Report Source Type: research

The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice
Discussion To meet the practical needs of our transgenic studies, we crossed the BL10-background mdx mice with FVB/NJ mice. Recent studies suggest that the so-called “wild type” inbred mice may actually carry various changes in their genome. For example, the commonly used A/J mice were recently show to display progressive muscular dystrophy due to a mutation in the dysferlin gene 24. The FVB strain was also found to carry mutations in several genes of the visual system 25. It is thus important to determine whether the FVB background alters the dystrophic phenotype of the original mdx mice. After seven generations of ba...
Source: PLOS Currents Muscular Dystrophy - February 10, 2015 Category: Neurology Authors: Nalinda B. Wasala Source Type: research

Undiagnosed myopathy before surgery and safe anaesthesia table.
Authors: Trevisan CP, Accorsi A, Morandi LO, Mongini T, Savoia G, Gravino E, Angelini C, Tegazzin V Abstract Patients with muscle pathology are a challenge for anaesthesiologists because of possible life-threatening general anaesthesia complications. A review of the current medical literature on the issue clearly indicates that increasing awareness by anaesthesiologists in recent years has led to a reduction in the occurrence of adverse events in patients with diagnostically well-defined muscle disease. On the other hand, the current emerging aspect is that the great majority of complications concern subjects with ...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Malignant hyperthermia.
Abstract Malignant hyperthermia (MH) is a rare hereditary, mostly subclinical myopathy. Trigger substances, such as volatile anesthetic agents and the depolarizing muscle relaxant succinylcholine can induce a potentially fatal metabolic increase in predisposed patients caused by a dysregulation of the myoplasmic calcium (Ca) concentration. Mutations in the dihydropyridine ryanodine receptor complex in combination with the trigger substances are responsible for an uncontrolled release of Ca from the sarcoplasmic reticulum. This leads to activation of the contractile apparatus and a massive increase in cellular ener...
Source: Der Anaesthesist - November 12, 2014 Category: Anesthesiology Authors: Metterlein T, Schuster F, Graf BM, Anetseder M Tags: Anaesthesist Source Type: research

Thoracic epidural anaesthesia for awake thoracic surgery in severely dyspnoeic patients excluded from general anaesthesia
CONCLUSIONS TEATS with/without sedation was an alternative to GA for thoracotomy/thoracoscopy in severely dyspnoeic patients (MMRC grade 4, ASA 4) without postoperative sequelae.
Source: Interactive CardioVascular and Thoracic Surgery - October 24, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kiss, G., Claret, A., Desbordes, J., Porte, H. Tags: Anesthesia, Pleura Thoracic Source Type: research

Rocuronium and sugammadex use for the management of neuromuscular blockade in urgent abdominal surgery in a patient with Landouzy-Dejerine myopathy.
We report dose reduction to 0.8mg/kg for a 47-year-old female with Landouzy-Dejerine myopathy. Therefore, less dose of sugammadex was given to reverse the neuromuscular block. PMID: 25307303 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - October 9, 2014 Category: Anesthesiology Authors: Hélaine L, Le Cocq C, Saadi H, Abdelkrim N, Atti A Tags: Ann Fr Anesth Reanim Source Type: research

Anesthetic considerations in myofibrillar myopathy.
This study is the first report of anesthetic management of a patient with MFM. We report multiple anesthetic encounters of a child with genetically confirmed BAG3-myopathy, a subtype of MFM with severe childhood disease onset. A review of the anesthetic implications of the disease is provided, with specific exploration of possible susceptibility to malignant hyperthermia, rhabdomyolysis, and sensitivity to other anesthetic agents. PMID: 25216331 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - September 12, 2014 Category: Anesthesiology Authors: Latham GJ, Lopez G Tags: Paediatr Anaesth Source Type: research

Anesthetic considerations in myofibrillar myopathy
This study is the first report of anesthetic management of a patient with MFM. We report multiple anesthetic encounters of a child with genetically confirmed BAG3‐myopathy, a subtype of MFM with severe childhood disease onset. A review of the anesthetic implications of the disease is provided, with specific exploration of possible susceptibility to malignant hyperthermia, rhabdomyolysis, and sensitivity to other anesthetic agents.
Source: Pediatric Anesthesia - September 12, 2014 Category: Anesthesiology Authors: Gregory J. Latham, Grace Lopez Tags: Review Article Source Type: research

G.P.8: Dramatic improvement after injection augmentation in oculopharyngodistal myopathy
We examined the patient, and performed all the tests during preoperative and postoperative 1st week, 1st month and 3rd month visits. No complications occurred during or after the procedure. The method was very successful in that aspirations stopped immediately after the injection, the voice became less hoarse and speech was more understandable. Augmentation was more effective for aspiration than for voice quality. Oculopharyngodistal myopathy is a non-curable genetic disease which threatens life due to respiratory insufficiency even in ambulatory patients. Application of vocal cord injection augmentation can be a promising...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: O. Ozcan, H. Durmus, O. Tarhan, Z. Polat, F. Deymeer, Y. Parman, P. Oflazer-Serdaroglu Source Type: research

Early changes of muscle membrane properties in porcine faecal peritonitis
IntroductionSepsis-induced myopathy and critical illness myopathy (CIM) are possible causes of muscle weakness in intensive care patients. They have been attributed to muscle membrane dysfunction. The aim of this study was to investigate membrane properties in the early stage of experimental sepsis by evaluating muscle excitability. Methods: In total, 20 anesthetized and mechanically ventilated pigs were randomized to either faecal peritonitis (n?=?10) or to non-septic controls (n?=?10). Resuscitation with fluids and vasoactive drugs was started 3?hours after peritonitis induction. Muscle membrane properties were investiga...
Source: Critical Care - August 22, 2014 Category: Intensive Care Authors: Karin AckermannHugh BostockLukas BranderRalph SchröderSiamak DjafarzadehDaniel TuchschererStephan JakobJukka TakalaWerner Z¿Graggen Source Type: research

Obstetric Outcome in a Primigravid Patient With Autosomal-Recessive Multiminicore Myopathy.
CONCLUSION:: A successful pregnancy outcome was achieved in a patient with multiminicore myopathy by proactively addressing potential genetic, orthopedic, and anesthetic concerns associated with this condition. PMID: 24413229 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - January 10, 2014 Category: OBGYN Authors: Klaska C, Gonik B Tags: Obstet Gynecol Source Type: research

Dilative vasculopathy and cerebral haemorrhage as a presentation of late-onset pompe disease
Conclusion Vasculopathy is an under recognised complication of Pompe disease. The subsequent intracerebral and subarachnoidal heamorrhages can be the presenting feature leading to diagnosis of Pompe disease, despite symptoms of the disease often being present for a number of years previously. With the advent of enzyme replacement which has revolutionised treatment, particularly in paediatric populations, it is important to diagnose this disorder early. Dry blood spot analysis for acid maltase enzyme activity provides a low cost way of screening for Pompe disease which should be considered in any adult patient presenting wi...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Roberts, M., Boothman, B. Tags: Genetics, Muscle disease, Neuromuscular disease, Radiology, Musculoskeletal syndromes, Surgical diagnostic tests Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Evaluation of suspected malignant hyperthermia events during anesthesia
Conclusions: MH is still an important anesthetic complication. Every anesthetist must be aware of this life-threatening syndrome at any time. The rapid onset of adequate therapy is crucial to avoid major harm and possibly lethal outcome. Dantrolene must be readily available wherever MH triggering agents are used for anesthesia.
Source: BMC Anesthesiology - September 23, 2013 Category: Anesthesiology Authors: Frank SchusterStephan JohannsenDaniel SchneiderbangerNorbert Roewer Source Type: research