Early changes of muscle membrane properties in porcine faecal peritonitis

IntroductionSepsis-induced myopathy and critical illness myopathy (CIM) are possible causes of muscle weakness in intensive care patients. They have been attributed to muscle membrane dysfunction. The aim of this study was to investigate membrane properties in the early stage of experimental sepsis by evaluating muscle excitability. Methods: In total, 20 anesthetized and mechanically ventilated pigs were randomized to either faecal peritonitis (n?=?10) or to non-septic controls (n?=?10). Resuscitation with fluids and vasoactive drugs was started 3?hours after peritonitis induction. Muscle membrane properties were investigated by measuring muscle velocity recovery cycles before induction of peritonitis as well as 6, 18 and 27?hours thereafter. Muscle relative refractory period (MRRP) and early supernormality (ESN) were assessed. Results: Peritonitis lasting 27?hours was associated with an increase of MRRP by 28% from 2.38???0.18?ms (mean???SD) to 3.47???1.79?ms (P
Source: Critical Care - Category: Intensive Care Authors: Source Type: research