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Procedure: Anesthesia

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Total 115 results found since Jan 2013.

The HDAC Inhibitor TSA Ameliorates a Zebrafish Model of Duchenne Muscular Dystrophy
Discussion Our results identify a dmd morpholino cocktail that induces a high penetrance of muscle lesions and strongly resembles the zebrafish dmd mutant phenotype. We also show that the HDAC inhibitor TSA rescues both dmd-MO and dmd mutant muscle lesions. By comparing different approaches to scoring muscle lesions, our study confirms a previous report 13 that simple assessment of the muscle birefringence pattern in whole larvae, using a stereomicroscope, is a reliable approach to scoring the dmd-MO or dmd mutant phenotype following chemical treatment. Thus, our work identifies optimal morpholino and phenotypic scoring ap...
Source: PLOS Currents Muscular Dystrophy - September 17, 2013 Category: Neurology Authors: njohnso8 Source Type: research

Combination of general anaesthesia and postoperative epidural analgesia in mitochondrial myopathy.
PMID: 23993216 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - August 28, 2013 Category: Anesthesiology Authors: Gentili ME, Raud C, Enel D, Hénot M, Bothereau H Tags: Ann Fr Anesth Reanim Source Type: research

Analysis of histomorphology in malignant hyperthermia-susceptible patients.
CONCLUSION: Despite the inability of the histomorphological examination to identify consistent features in MHS patients, histology may serve as a potential adjunct to CHCT and aid in the identification of other myopathies. Nevertheless, the specifics of its utility ought to be assessed in other studies and by way of formal cost-effectiveness analysis. PMID: 23888335 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - July 26, 2013 Category: Anesthesiology Authors: Orlov D, Keith J, Rosen D, Croul S, Kraeva N, Riazi S Tags: Can J Anaesth Source Type: research

Mitochondrial diseases and anesthesia: a literature review of current opinions.
Abstract This course explores the considerations that the anesthesia provider has to be aware of, when caring for a patient with a mitochondrial myopathy. Even though these disorders are rare, these patients may also need surgical care, requiring that the anesthesia provider be informed of the best anesthesia options to consider. A narrative review of documented cases and their outcomes is used to generate a resource of current opinions in the anesthetic care of this patient population. PMID: 23923677 [PubMed - in process]
Source: AANA Journal - June 1, 2013 Category: Anesthesiology Authors: Rivera-Cruz B Tags: AANA J Source Type: research

Core myopathies and malignant hyperthermia susceptibility: a review
Summary The core myopathies are a subset of myopathies that present in infancy with hypotonia and muscle weakness. They were formerly considered a rare type of congenital myopathy but are now recognized as being more prevalent. Due to their genetic linkage to mutations in the ryanodine receptor gene (RYR1), core myopathies (in particular, central core disease) carry a high risk of malignant hyperthermia susceptibility. In this review article, we describe the phenotypical, genetic, and histopathological characteristics of core myopathies and further describe the currently understood nature of their risk of malignant hyperth...
Source: Pediatric Anesthesia - April 25, 2013 Category: Anesthesiology Authors: Robert P. Brislin, Mary C. Theroux Tags: Review Article Source Type: research

Core myopathies and malignant hyperthermia susceptibility: a review.
Abstract The core myopathies are a subset of myopathies that present in infancy with hypotonia and muscle weakness. They were formerly considered a rare type of congenital myopathy but are now recognized as being more prevalent. Due to their genetic linkage to mutations in the ryanodine receptor gene (RYR1), core myopathies (in particular, central core disease) carry a high risk of malignant hyperthermia susceptibility. In this review article, we describe the phenotypical, genetic, and histopathological characteristics of core myopathies and further describe the currently understood nature of their risk of maligna...
Source: Paediatric Anaesthesia - April 25, 2013 Category: Anesthesiology Authors: Brislin RP, Theroux MC Tags: Paediatr Anaesth Source Type: research

Postanesthetic Neuropathy/Myopathy in the Nondependent Forelimb in 4 Horses
Abstract: Postanesthetic lameness in the form of myopathy or neuropathy is a well-known complication associated with equine general anesthesia and is most often reported in the dependent limb of horses treated in lateral recumbency. The aim of this case series was to report clinical data of 4 horses treated under general anesthesia in lateral recumbency and that developed postanesthetic neuropathy/myopathy in the nondependent forelimb. With anti-inflammatory and analgesic medical treatment, locomotor problems associated with neuropathy/myopathy resolved after 12–24 hours in all cases. The pathogenesis remains unclear. A ...
Source: Journal of Equine Veterinary Science - April 22, 2013 Category: Veterinary Research Authors: Maarten Oosterlinck, Stijn Schauvliege, Ann Martens, Frederik Pille Tags: Original Research Source Type: research

A Novel Method for Targeting Intramuscular Diaphragm Injections Using Ultrasound and Electromyography (P02.220)
CONCLUSIONS: This study demonstrates the feasibility and practicality of using ultrasound to guide injections and needle EMG in animal models in an effort to reduce complications associated with conventional blind technique. Further, this new method demonstrates the feasibility of targeted diaphragm injections with gene replacement therapy in muscle diseases.Supported by: MDA (Muscular Dystrophy Association); AFM (Association Francais Contre les Myopathy); Joshua Frase Foundation.Disclosure: Dr. Sarwal has nothing to disclose. Dr. Serfas has nothing to disclose. Dr. Mitchell has nothing to disclose. Dr. Cartwright has noth...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sarwal, A., Serfas, J. D., Mitchell, E., Cartwright, M., Beggs, A., Buj-Bello, A., Childers, M. Tags: P02 Clinical Neurophysiology: EMG Source Type: research

Myotonic Dystrophies type 1 and 2: anesthetic care.
Abstract SUMMARY: Myotonic dystrophy is classified as one of the myotonic syndromes although myotonia is only a minor characteristic of it. It is, in fact, also a multisystem disease with cardiac, digestive, ocular, and endocrine abnormalities. Two subgroups are currently identified with many similarities: DM1 refers to classic dystrophia myotonica (Steinert disease), while DM2, formerly called proximal myotonic myopathy has a later onset. The congenital form is present only in DM1. The genetic causes of DM1 and 2 are different but end up in a similar way of altering RNAm processing and splicing of other genes. Th...
Source: Paediatric Anaesthesia - February 5, 2013 Category: Anesthesiology Authors: Veyckemans F, Scholtes JL Tags: Paediatr Anaesth Source Type: research

Myotonic Dystrophies type 1 and 2: anesthetic care
SummaryMyotonic dystrophy is classified as one of the myotonic syndromes although myotonia is only a minor characteristic of it. It is, in fact, also a multisystem disease with cardiac, digestive, ocular, and endocrine abnormalities. Two subgroups are currently identified with many similarities: DM1 refers to classic dystrophia myotonica (Steinert disease), while DM2, formerly called proximal myotonic myopathy has a later onset. The congenital form is present only in DM1. The genetic causes of DM1 and 2 are different but end up in a similar way of altering RNAm processing and splicing of other genes. The anesthetic risk is...
Source: Pediatric Anesthesia - February 1, 2013 Category: Anesthesiology Authors: Francis Veyckemans, Jean‐Louis Scholtes Tags: Review Article Source Type: research