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Total 106 results found since Jan 2013.

Effect of Transcutaneous Electrical Neuromuscular Stimulation on Myopathy in Intensive Care Patients.
CONCLUSION: TENMS had no significant impact on myopathy in the critically ill patients in this study. PMID: 30385541 [PubMed - in process]
Source: American Journal of Critical Care - November 1, 2018 Category: Nursing Authors: Koutsioumpa E, Makris D, Theochari A, Bagka D, Stathakis S, Manoulakas E, Sgantzos M, Zakynthinos E Tags: Am J Crit Care Source Type: research

Diabetes mellitus tendino-myopathy: epidemiology, clinical features, diagnosis and management of an overlooked diabetic complication
AbstractTendino-myopathy, an unexplored niche, is a non-vascular unstated T2DM complication, which is largely disregarded in clinical practice, thus, we aim to explore it in this review. Literature search using published data from different online resources. Epidemiologically, reported prevalence varies around 10 –90%, which is marked variable and unreliable. Clinically, diabetic tendino-myopathy is typified by restriction of movement, pain/tenderness, cramps and decreased functions. Moreover, myopathy is characterized by muscle atrophy, weakness and ischemia, and tendinopathy by deformities and reduced fu nctions/precis...
Source: Acta Diabetologica - March 15, 2022 Category: Endocrinology Source Type: research

Comparison of gluteus medius muscle activity in Haflinger and Noriker horses with polysaccharide storage myopathy
AbstractType 1 polysaccharide storage myopathy caused by genetic mutation in the glycogen synthase 1 gene is present in many breeds including the Noriker and Haflinger horses. In humans, EMG has already been used to document changes in the muscle activity patterns of patients affected by human glycogen storage disorders. Therefore, the aim of the present study was to describe gluteus muscle activity with surface electromyography (sEMG) in Haflinger and Noriker horses with known GYS1 mutation status during walk and trot. Thirty ‐two horses (11 Haflinger and 21 Noriker horses) with homozygous non‐affected (GG), heterozyg...
Source: Journal of Animal Physiology and Animal Nutrition - February 21, 2021 Category: Zoology Authors: Rebeka Roza Zsoldos, Negar Khayatzadeh, Johann Soelkner, Ulrike Schroeder, Caroline Hahn, Theresia Franziska Licka Tags: ORIGINAL ARTICLE Source Type: research

Critical illness myopathy in intensive care setting
ConclusionNMES is not superior to usual care in management of CIM. Usual care remains the mainstay of management of CIM with significant better outcomes, in addition to preventive measures as early aggressive treatment of sepsis and MOF, blood glucose control, optimizing certain drugs use, early enteral nutrition, maintaining water, electrolyte and acidbase balance.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research

Generation of CHOPi012-A iPSC line from a patient with visceral myopathy-related chronic intestinal pseudo-obstruction
Stem Cell Res. 2023 Aug 1;71:103176. doi: 10.1016/j.scr.2023.103176. Online ahead of print.ABSTRACTVisceral myopathies are debilitating conditions characterized by dysfunction of smooth muscle in visceral organs (bowel, bladder, and uterus). Individuals affected by visceral myopathy experience feeding difficulties, growth failure, life-threatening abdominal distension, and may depend on intravenous nutrition for survival. Unfortunately, our limited understanding of the pathophysiology of visceral myopathies means that current therapies remain supportive, with no mechanism-based treatments. We developed a patient-derived iP...
Source: Cell Research - August 12, 2023 Category: Cytology Authors: Sohaib K Hashmi Sabine Schneider Alyssa L Gagne Jean Ann Maguire Paul Gadue Robert O Heuckeroth Deborah L French Source Type: research

Quantum Blue Reduces the Severity of Woody Breast Myopathy via Modulation of Oxygen Homeostasis-Related Genes in Broiler Chickens
In this study, using diffuse reflectance spectroscopy (DRS) coupled with iSTAT portable clinical analyzer, we provide evidence that the circulatory- and breast muscle-oxygen homeostasis is dysregulated [low oxygen and hemoglobin (HB) levels] in chickens with WB myopathy compared to healthy counterparts. Molecular analysis showed that blood HB subunit Mu (HBM), Zeta (HBZ), and hephaestin (HEPH) expression were significantly down regulated; however, the expression of the subunit rho of HB beta (HBBR) was upregulated in chicken with WB compared to healthy counterparts. The breast muscle HBBR, HBE, HBZ, and hypoxia-inducible f...
Source: Frontiers in Physiology - September 30, 2019 Category: Physiology Source Type: research

Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
Purpose of review We would like to inform clinicians that the systematic administration of oral and intravenous L-arginine is therapeutically beneficial and clinically useful for patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), when they maintain plasma arginine concentration at least 168 μmol/l. Recent findings MELAS is associated with endothelial dysfunction by decreased plasma L-arginine, nitric oxide (NO), and cyclic guanosine monophosphate. Endothelial dysfunction is also evident using flow-mediated vasodilation measurement by high-resolution Doppler echo...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - November 28, 2019 Category: Nutrition Tags: PROTEIN, AMINO ACID METABOLISM AND THERAPY: Edited by Rajavel Elango and Alessandro Laviano Source Type: research

Determining the risk factors and clinical features associated with severe gastrointestinal dysmotility in systemic sclerosis
ConclusionDistinct clinical features are present in SSc patients who are at risk of developing severe GI dysmotility. This finding is not only important clinically but also suggests that a unique pathological process is present in these patients.This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - November 28, 2017 Category: Rheumatology Authors: Zsuzsanna H. McMahan, Julie J. Paik, Fredrick M. Wigley, Laura K. Hummers Tags: Original Article Source Type: research

Diagnostic Criteria of Pediatric Intestinal Myopathies
The authors aim to identify criteria for the diagnosis of intestinal visceral myopathy (IVM); results were compared with ultrastructural studies. Six IVM patients and 7 pediatric control cases (without gastrointestinal diseases) were studied. One case was a typical megacystis-microcolon-intestinal hypoperistalsis syndrome. The diagnostic path included: rectal suction biopsy, one-trocar transumbilical laparoscopic intestinal full-thickness biopsy technique. Pathological analysis included anti-alpha smooth muscle actin staining, and US study of intestinal biopsies. IVM histological examination demonstrated thinning of longit...
Source: Journal of Pediatric Gastroenterology and Nutrition - February 24, 2018 Category: Gastroenterology Tags: Short Communications: Gastroenterology Source Type: research

Effects of dietary sodium selenite and organic selenium sources on immune and inflammatory responses and selenium deposition in growing pigs
This study was conducted to compare effects of different dietary Se sources (sodium selenite [NaSe], Se-enriched yeast [Se yeast] or L-selenomethionine [SeMet]) and one Se-deficient control diet on the expression of selected genes, hematological and clinical biochemical parameters, and muscle morphology in two parallel trials with finisher pigs. Se concentrations in blood plasma and tissues were also monitored. From the pigs in one of the parallel groups, muscle samples obtained from Musculus longissimus dorsi (LD) before and during the trial were examined. The pigs in the other parallel group were challenged once with lip...
Source: Journal of Trace Elements in Medicine and Biology - March 9, 2018 Category: Biochemistry Source Type: research

Adverse Events to Food Supplements Containing Red Yeast Rice: Comparative Analysis of FAERS and CAERS Reporting Systems
ConclusionsNotwithstanding recognized limitations, these findings strengthen the importance of exploring multiple databases in safety assessment of RYR products, which should be monitored by clinicians for muscular and hepatic safety, and call for urgent review by policymakers to harmonize their regulatory status.
Source: Drug Safety - March 26, 2018 Category: Drugs & Pharmacology Source Type: research

Mechanisms Underlying Muscle Protein Imbalance Induced by Alcohol.
Abstract Both acute intoxication and longer-term cumulative ingestion of alcohol negatively impact the metabolic phenotype of both skeletal and cardiac muscle, independent of overt protein calorie malnutrition, resulting in loss of skeletal muscle strength and cardiac contractility. In large part, these alcohol-induced changes are mediated by a decrease in protein synthesis that in turn is governed by impaired activity of a protein kinase, the mechanistic target of rapamycin (mTOR). Herein, we summarize recent advances in understanding mTOR signal transduction, similarities and differences between the effects of a...
Source: Annual Review of Nutrition - August 21, 2018 Category: Nutrition Authors: Kimball SR, Lang CH Tags: Annu Rev Nutr Source Type: research