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Total 36 results found since Jan 2013.

Bibliometric and altmetric analyses of publication activity in the field of idiopathic inflammatory myopathy in 2011 –2021 based on web of science core collection databases
AbstractIdiopathic inflammatory myopathy is a multisystem autoimmune condition characterized by muscle inflammation (myositis) and interstitial lung disease (ILD). Bibliometric analysis and altmetric analysis are effective methods of evaluating academic productivity and measuring the influence of publications. The purpose of this study is to analyze the research productivity and influence of idiopathic inflammatory myopathy articles using bibliometric analysis and altmetric analysis. Data from articles published between 2011 and 2021 were obtained from the Web of Science. Altmetric attention scores and Mendeley reader coun...
Source: Rheumatology International - April 25, 2023 Category: Rheumatology Source Type: research

OptimisAtion of Diagnostic Accuracy in idioPathic inflammaTory myopathies (ADAPT study): a protocol for a prospective diagnostic accuracy study of multimodality testing in patients suspected of a treatable idiopathic inflammatory myopathy
Introduction Idiopathic inflammatory myopathies (IIMs) excluding inclusion body myositis (IBM) are a group of heterogeneous autoimmune disorders characterised by subacute-onset and progressive proximal muscle weakness, which are frequently part of a multisystem autoimmune disorder. Reaching the diagnosis can be challenging, and no gold standard for the diagnosis of IIM exists. Diagnostic modalities include serum creatine kinase activity, muscle imaging (MRI or ultrasound (US)), electromyography (EMG), myositis autoantibody testing and muscle biopsy. Several diagnostic criteria have been developed for IIMs, varying in repor...
Source: BMJ Open - December 13, 2021 Category: General Medicine Authors: Walter, H. A. W., Kamperman, R. G., Raaphorst, J., Verhamme, C., Koelman, J. H. T. M., Potters, W. V., Hemke, R., Smithuis, F. F., Aronica, E., van Leeuwen, E. M. M., Baars, P. A., de Visser, M., van Schaik, I. N., Bossuyt, P. M. M., van der Kooi, A. J. Tags: Open access, Rheumatology Source Type: research

Sporadic inclusion body myositis and primary Sjogren ’s syndrome: an overlooked diagnosis
AbstractSporadic inclusion body myositis (sIBM) has been reported to occur in association with autoimmune diseases and in particular, primary Sjogren ’s syndrome (pSS). This brief report describes patients identified with a positive SSA antibody and diagnosis of sIBM at a large academic medical center over a 13.5-year period. A cohort identification tool was used to identify patients with positive SSA antibody and a diagnosis of sIBM between Ja nuary 1, 2006 and June 1, 2019. All cases of sIBM had diagnostic confirmation by a neuromuscular specialist. Demographics, clinical features, autoantibodies, MRI and EMG findings,...
Source: Clinical Rheumatology - April 21, 2021 Category: Rheumatology Source Type: research

Unveiling outcomes in coexisting severe aortic stenosis and transthyretin cardiac amyloidosis
ConclusionIn moderate ‐risk patients with severe AS undergoing TAVR, there was a 13% prevalence of ATTR‐CA, which did not affect mortality. The observed increase in heart failure hospitalization following TAVR in those with ATTR‐CA suggests the consequences of the underlying infiltrative myopathy.
Source: European Journal of Heart Failure - March 30, 2021 Category: Cardiology Authors: Hannah Rosenblum, Ahmad Masri, David L. Narotsky, Jeff Goldsmith, Nadira Hamid, Rebecca T. Hahn, Susheel Kodali, Torsten Vahl, Tamim Nazif, Omar K. Khalique, Sabahat Bokhari, Prem Soman, Jo ão L. Cavalcante, Mathew S. Maurer, Adam Castaño Tags: Research article Source Type: research

Musculoskeletal sarcoidosis: A single center experience over 15 years
ConclusionWe identified a large cohort of MSK sarcoidosis and determined the prevalence of all 4 subtypes. In patients who do develop MSK manifestations of sarcoidosis, they are commonly a part of the initial presentation of sarcoidosis. There is an unmet need to establish standardized classification criteria for the 4 MSK sarcoidosis syndromes.
Source: International Journal of Rheumatic Diseases - February 11, 2021 Category: Rheumatology Authors: Sanjeev Patil, Carolyn A. Hilliard, Masumi Arakane, Sreedevi Koppisetti Jenigiri, Elizabeth H. Field, Namrata Singh Tags: ORIGINAL ARTICLE Source Type: research

Chloroquine- and Hydroxychloroquine-Induced Cardiomyopathy: A Case Report and Brief Literature Review.
CONCLUSION: CQ and HCQ myopathy can present following long-term administration of the drug. The pathologic findings are nonspecific and overlap with other vacuolated myopathies, necessitating careful correlation of the histologic changes with the patient's medical history. PMID: 33316045 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - December 14, 2020 Category: Pathology Authors: Nadeem U, Raafey M, Kim G, Treger J, Pytel P, N Husain A, Schulte JJ Tags: Am J Clin Pathol Source Type: research

Novel heterozygous truncating titin variants affecting the A ‐band are associated with cardiomyopathy and myopathy/muscular dystrophy
ConclusionAlthough heterozygousTTNtv in the A ‐band is known to cause dilated cardiomyopathy, we present evidence that these variants may in some cases cause a novel, dominant skeletal myopathy with a limb‐girdle pattern of weakness. These findings emphasize the importance of multidisciplinary care for patients with A‐bandTTNtv who may be at risk for multisystem disease.
Source: Molecular Genetics & Genomic Medicine - August 19, 2020 Category: Genetics & Stem Cells Authors: Kelly A. Rich, Tia Moscarello, Carly Siskind, Guy Brock, Christopher A. Tan, Matteo Vatta, Thomas L. Winder, Bakri Elsheikh, Leah Vicini, Brianna Tucker, Marilly Palettas, Ray E. Hershberger, John T. Kissel, Ana Morales, Jennifer Roggenbuck Tags: ORIGINAL ARTICLE Source Type: research

Unveiling Outcomes in Coexisting Severe Aortic Stenosis and Transthyretin Cardiac Amyloidosis
ConclusionIn moderate ‐risk patients with severe AS undergoing TAVR, there was a 13% prevalence of ATTR‐CA, which did not affect mortality. The observed increase in HF hospitalization following TAVR in those with ATTR‐CA suggests the consequences of the underlying infiltrative myopathy.
Source: European Journal of Heart Failure - July 29, 2020 Category: Cardiology Authors: Hannah Rosenblum, Ahmad Masri, David L. Narotsky, Jeff Goldsmith, Nadira Hamid, Rebecca T. Hahn, Susheel Kodali, Torsten Vahl, Tamim Nazif, Omar K. Khalique, Sabahat Bokhari, Prem Soman, Jo ão L. Cavalcante, Mathew S Maurer, Adam Castaño Tags: Research Article Source Type: research

Safety and efficacy of intravenous bimagrumab in inclusion body myositis (RESILIENT): a randomised, double-blind, placebo-controlled phase 2b trial
Publication date: September 2019Source: The Lancet Neurology, Volume 18, Issue 9Author(s): Michael G Hanna, Umesh A Badrising, Olivier Benveniste, Thomas E Lloyd, Merrilee Needham, Hector Chinoy, Masashi Aoki, Pedro M Machado, Christina Liang, Katrina A Reardon, Marianne de Visser, Dana P Ascherman, Richard J Barohn, Mazen M Dimachkie, James A L Miller, John T Kissel, Björn Oskarsson, Nanette C Joyce, Peter Van den Bergh, Jonathan BaetsSummaryBackgroundInclusion body myositis is an idiopathic inflammatory myopathy and the most common myopathy affecting people older than 50 years. To date, there are no effective drug treat...
Source: The Lancet Neurology - August 8, 2019 Category: Neurology Source Type: research

Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis
Discussion Our main finding is that LAG-3 and TIM-3 expression levels in the PBMCs of MS patients can aid to predict disease outcome. Lower LAG-3 and TIM-3 expression were associated with the worst outcome and increased likelihood to progress to SPMS, while higher LAG-3 and TIM-3 expression correlated significantly with benign prognosis, persisting RRMS, and lower EDSS score at 10 years after blood sampling. Analysis of the paraclinical and clinical parameters baseline brain MRI T2LV, EDSS at diagnosis, and 1-year progression index combined with LAG-3 and TIM-3 expression levels resulted in superior ability to identify pa...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies
Conclusion: The data hold promise for advancements in standardization of MSA assays as well as for the potential inclusion of MSA in future classification criteria. Introduction Myositis specific (MSA) and myositis associated antibodies (MAA) have been used as an aid in the diagnosis of idiopathic inflammatory myopathies (IIM) for decades (1). Since many of the MSA (e.g., anti-synthetase antibodies), partly depending on the screening dilution, are accompanied by limited sensitivity of the indirect immunofluorescence (IIF) test, this method has limited utility as a screening test for suspected myositis (2–6)...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research