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Infectious Disease: Gastroenteritis
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Climate Crisis: What Gastrointestinal Complications of this Medical Emergency Should We Be Aware Of?
DISCUSSION: Adaptation strategies must be consistently developed and implemented for vulnerable groups. Patients at risk should be informed about measures that can be implemented individually, such as avoiding heat, ensuring appropriate hydration and following hygiene instructions. Recommendations for physical activity and a healthy and sustainable diet are essential for the prevention of liver diseases and carcinomas. Measures for prevention and the promotion of resilience can be supported by the physicians at various levels. In addition to efforts fostering sustainability in the immediate working environment, a system-or...
Source: Zeitschrift fur Gastroenterologie - April 12, 2023 Category: Gastroenterology Authors: Jens Walldorf Nikolaus Christian Simon Mezger Lena Weber Anja Knothe Michelle Klose Stefan Moritz Eva Johanna Kantelhardt Stephan Feller Axel Schlitt Robin Greinert Patrick Michl Source Type: research
UK raises alarm on deadly rise of superbugs
Britain to call for G8 action against spread of drug-resistant bacteria by clamping down on overuse of antibioticsBritain is to urge the G8 to take action against the spread of drug-resistant microbes as medical and veterinary experts warn that co-ordinated international action is needed to prevent soaring rates of potentially lethal infections turning into a public health catastrophe.David Willetts, the science minister, will propose far-reaching measures that would clamp down on the overuse of antibiotics by GPs and hospital doctors. He will also try to restrict usage on farms and fisheries, where the drugs are blended w...
Source: Guardian Unlimited Science - June 11, 2013 Category: Science Authors: Ian Sample, Fiona Harvey, Denis Campbell Tags: The Guardian World news Health Medical research Society Drugs Antibiotics UK news Drug resistance G8 Science Source Type: news
Reshaping of the conformational search of a protein by the chaperone trigger factor
& Sander J. Tans
Protein folding is often described as a search process, in which polypeptides explore different conformations to find their native structure. Molecular chaperones are known to improve folding yields by suppressing aggregation between polypeptides before this conformational search starts, as well as by rescuing misfolds after it ends. Although chaperones have long been speculated to also affect the conformational search itself—by reshaping the underlying folding landscape along the folding trajectory—direct experimental evidence has been scarce so far. In Escherichia coli, the general c...
Source: Nature - July 7, 2013 Category: Research Authors: Alireza MashaghiGünter KramerPhilipp BechtluftBeate Zachmann-BrandArnold J. M. DriessenBernd BukauSander J. Tans Tags: Letter Source Type: research
Association of glycerol kinase gene with class 3 integrons: A novel cassette array within Escherichia coli
Conclusion: This study provides epidemiological profiling of Class 3 integrons in this geographical area. The data generated in this study are helpful in infection control programme, anti-infective research and search for epidemiological markers.
Source: Indian Journal of Medical Microbiology - May 2, 2018 Category: Microbiology Authors: Rajkumari Elizabeth Debadatta Dhar Chanda Atanu Chakravarty Deepjyoti Paul Shiela Chetri Deepshikha Bhowmik Jayalaxmi Wangkheimayum Amitabha Bhattacharjee Source Type: research
Dynamics of chromosomal target search by a membrane-integrated one-component receptor
by Linda Martini, Sophie Brameyer, Elisabeth Hoyer, Kirsten Jung, Ulrich Gerland
Membrane proteins account for about one third of the cellular proteome, but it is still unclear how dynamic they are and how they establish functional contacts with cytoplasmic interaction partners. Here, we consider a membrane-integrated one-component receptor that also acts as a transcriptional activator, and analyze how it kinetically locates its specific binding site on the genome. We focus on the case of CadC, the pH receptor of the acid stress response Cad system inE. coli. CadC is a prime example of a one-component signaling protein th...
Source: PLoS Computational Biology - February 4, 2021 Category: Biology Authors: Linda Martini Source Type: research
Crystal structure of a hypothetical protein from Giardia lamblia
This article is an educational collaboration between Hampton University and the Seattle Structural Genomics Center for Infectious Disease.
Source: Acta Crystallographica Section F - January 28, 2022 Category: Biochemistry Authors: Beard, D.K. Bristol, S. Cosby, K. Davis, A. Manning, C. Perry, L. Snapp, L. Toy, A. Wheeler, K. Young, J. Staker, B. Arakaki, T.L. Abendroth, J. Subrahamanian, S. Edwards, T.E. Myler, P.J. Asojo, O.A. Tags: giardiasis SSGCID infectious diseases travelers' diarrhea undergraduate education and training structural genomics research communications Source Type: research
Reshaping of the conformational search of a protein by the chaperone trigger factor
Nature advance online publication 07 July 2013. doi:10.1038/nature12293
Authors: Alireza Mashaghi, Günter Kramer, Philipp Bechtluft, Beate Zachmann-Brand, Arnold J. M. Driessen, Bernd Bukau & Sander J. Tans
Protein folding is often described as a search process, in which polypeptides explore different conformations to find their native structure. Molecular chaperones are known to improve folding yields by suppressing aggregation between polypeptides before this conformational search starts, as well as by rescuing misfolds after it ends. Although chaperones have long been speculated to also affect the conformation...
Source: Nature AOP - July 7, 2013 Category: Research Authors: Alireza MashaghiGünter KramerPhilipp BechtluftBeate Zachmann-BrandArnold J. M. DriessenBernd BukauSander J. Tans Tags: Letter Source Type: research
Screening of the novel colicinogenic gram-negative rods against pathogenic Escherichia coli O157:H7
Conclusion: Nonhaemolytic, acid tolerant and sensitive to antibiotics suggests the possible use of these circulating endothelial cells (CEC) as inexpensive and inoffensive therapeutic agent (probiotics) in E. coli O157:H7 infections.
Source: Indian Journal of Medical Microbiology - February 6, 2015 Category: Microbiology Authors: M RizwanB AhmadJ BakhtH MushtaqN Bacha Source Type: research
