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Total 4425348 results found since Jan 2013.
Did COVID-19 Change the Availability and Use of Clean Energy for Cooking? Evidence From Ghana
This study provides insights that could be valuable in future understanding of the interactions between pandemic control measures and economic disruptions that may affect household energy choices for cooking.PMID:37736574 | PMC:PMC10510355 | DOI:10.1177/11786302231198854
Source: Environmental Health Insights - September 22, 2023 Category: Environmental Health Authors: Rebecca Kd Prah Darby Jack Theresa Tawiah Seidu Iddrisu Sulemana Watara Abubakari Mohammed Nuhu Mujtaba Richard Joshua Tetteh Stephaney Gyaase Mieks Twumasi Jason Saah Joseph Wilson Sheila Addo Daniel Pope Kwaku Poku Asante Elisa Puzzolo Source Type: research
Findings of Research Misconduct
Fed Regist. 2023 Sep 1;88(169):60466-60467.NO ABSTRACTPMID:37736656 | PMC:PMC10473901
Source: Fed Regist - September 22, 2023 Category: American Health Source Type: research
Depletion of mTOR ameliorates CD < sub > 4 < /sub > < sup > + < /sup > T cell pyroptosis by promoting autophagy activity in septic mice
In this study, a septic mouse model was developed using cecal ligation and puncture (CLP) to explore the degree of pyroptosis and autophagy of CD4+ T cells. T-cell-specific mTOR/TSC1-knockout mice were used to investigate the role of mTOR pathway in the regulation of CD4+ T cell pyroptosis. Bafilomycin, a specific autophagy inhibitor, was used to verify the regulatory effect of autophagy on pyroptosis in septic mice. We observed aggravated pyroptosis in CD4+ T cells in CLP mice accompanied by impaired autophagy activity and an overactivated mTOR signaling pathway. Depletion of mTOR relieved autophagy deficiency and reduced...
Source: International Immunopharmacology - September 22, 2023 Category: Allergy & Immunology Authors: Ran Guo Guoyu Zhao Guangxu Bai Jianwei Chen Wen Han Na Cui Hao Wang Source Type: research
Interdisciplinary collaboration in the diagnosis and management of chronic cough: the role and importance of primary care providers
The objective of this review is to describe the role of PCPs in the diagnosis and treatment of CC in adults. This narrative review draws upon literature (identified via a PubMed search performed January 9, 2023, using primary care/disease state-related terms) and expertise from specialist physicians to provide recommendations for CC management in primary care. Cough is one of the top reasons patients seek care from PCPs; accordingly, PCPs are often the first physicians to conduct workup and initiate treatment. Patients with CC often experience a burdensome cough that lasts for years, have high healthcare resource utilizati...
Source: Current Medical Research and Opinion - September 22, 2023 Category: Research Authors: Peter V Dicpinigaitis Kenneth W Altman Isil Ulger Isci Xuehua Ke Michael Blaiss Source Type: research
CYFIP2 serves as a prognostic biomarker and correlates with tumor immune microenvironment in human cancers
CONCLUSION: Our results suggested that CYFIP2 may serve as a prognostic cancer biomarker for determining prognosis and might be a promising therapeutic strategy for tumor immunotherapy.PMID:37735711 | DOI:10.1186/s40001-023-01366-2
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Qiliang Peng Bixin Ren Kedao Xin Weihui Liu Md Shahin Alam Yinyin Yang Xuhao Gu Yaqun Zhu Ye Tian Source Type: research
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
J Orthop Surg Res. 2023 Sep 22;18(1):713. doi: 10.1186/s13018-023-04119-3.ABSTRACTOsteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytok...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Source Type: research
Intravitreal allogeneic mesenchymal stem cells: a non-randomized phase II clinical trial for acute non-arteritic optic neuropathy
CONCLUSIONS: Besides the development of an epiretinal membrane in one patient, the intravitreal application of allogeneic BM-MSCs appeared to be intraocularly well tolerated. Consequently, not only NA-AION but also BM-MSCs deserve more clinical investigational resources and a larger randomized multicenter trial that would provide stronger evidence both about safety and the potential therapeutic efficacy of intravitreally injected allogeneic BM-MSCs in acute NA-AION.TRIAL REGISTRATION: Safety Assessment of Intravitreal Mesenchymal Stem Cells for Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NEUROSTEM). NCT03173638...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Jose C Pastor Salvador Pastor-Idoate Marina L ópez-Paniagua Marta Para Francisco Blazquez Esther Murgui Ver ónica García Rosa M Coco-Mart ín Source Type: research
Author Correction: Isolation and proteomic analysis of the SYP61 compartment reveal its role in exocytic trafficking in Arabidopsis
Cell Res. 2023 Sep 21. doi: 10.1038/s41422-023-00865-5. Online ahead of print.NO ABSTRACTPMID:37735620 | DOI:10.1038/s41422-023-00865-5
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Georgia Drakakaki Wilhelmina van de Ven Songqin Pan Yansong Miao Junqi Wang Nana F Keinath Brent Weatherly Liwen Jiang Karin Schumacher Glenn Hicks Natasha Raikhel Source Type: research
Advances of three-dimensional (3D) culture systems for in vitro spermatogenesis
Stem Cell Res Ther. 2023 Sep 21;14(1):262. doi: 10.1186/s13287-023-03466-6.ABSTRACTThe loss of germ cells and spermatogenic failure in non-obstructive azoospermia are believed to be the main causes of male infertility. Laboratory studies have used in vitro testicular models and different 3-dimensional (3D) culture systems for preservation, proliferation and differentiation of spermatogonial stem cells (SSCs) in recent decades. The establishment of testis-like structures would facilitate the study of drug and toxicity screening, pathological mechanisms and in vitro differentiation of SSCs which resulted in possible treatmen...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Maryam Salem Farnaz Khadivi Parinaz Javanbakht Sina Mojaverrostami Mehdi Abbasi Narjes Feizollahi Yasaman Abbasi Ehsan Heidarian Farzane Rezaei Yazdi Source Type: research
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
CONCLUSIONS: In this study we report that an inherent enrichment of distinct GSCs pools underpin the functional inter-cluster variances displayed by GBM patients. We uncover two selectively represented novel functional biomarkers capable of discriminating GBM patients' stratification, survival and drug response, setting the stage for the determination of patient-tailored diagnostic and prognostic strategies and, mostly, for the design of appropriate, patient-selective treatment protocols.PMID:37735434 | DOI:10.1186/s13046-023-02811-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Alberto Visioli Nadia Trivieri Gandino Mencarelli Fabrizio Giani Massimiliano Copetti Orazio Palumbo Riccardo Pracella Maria Grazia Cariglia Chiara Barile Luigi Mischitelli Amata Amy Soriano Pietro Palumbo Federico Legnani Francesco DiMeco Leonardo Gorgog Source Type: research
Evaluation of treatment patterns, healthcare resource utilization and cost of illness for sickle cell disease in Ghana: a private medical insurance claims database study
CONCLUSION: In this retrospective private insurance claims database analysis, SCD imposes a significant healthcare burden, especially in patients with VOC. There is a need for reimbursed treatment options that could reduce the long-term burden associated with SCD and VOC.PMID:37735428 | DOI:10.1186/s12913-023-09984-6
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Kwaku Marfo Yvonne Dei-Adomakoh Catherine Segbefia Duah Dwomoh Adeline Edgal Nancy Ampah Badarinath Chickballapur Ramachandrachar Kumaresan Subramanyam Ashok Natarajan Olufolake Egbujo Kenneth I Ataga Source Type: research
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice
CONCLUSIONS: Our study highlights the beneficial effects of hUC-MSC treatment on PND and provides a justification to consider the potential use of hUC-MSCs in the perioperative period.PMID:37735415 | DOI:10.1186/s13287-023-03499-x
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Penghui Wei Min Jia Xiangyi Kong Wenyuan Lyu Hao Feng Xinyi Sun Jianjun Li Jian-Jun Yang Source Type: research
