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Total 4425348 results found since Jan 2013.
Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis
DiscussionBoth Dex-CRH and Desmopressin tests can be valid tools in helping discrimination between NNH/pCS and CS. Further studies are needed on this topic, possibly focusing on mild Cushing ’s Disease and well-characterized NNH/pCS patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359774, identifier CRD42022359774.
Source: Journal of Endocrinological Investigation - September 22, 2023 Category: Endocrinology Source Type: research
Oxytocin treatment for core symptoms in children with autism spectrum disorder: a systematic review and meta-analysis
ConclusionWhile the therapeutic value of oxytocin in treating core symptoms of ASD in children is not fully established, the results of this meta-analysis indicate a potential moderate effect. However, further studies with larger sample sizes and more robust RCTs are needed to directly demonstrate the efficacy of oxytocin. Future research should also focus on effect size and outcome evaluation accuracy while minimizing bias in RCT experiments.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
LABA/LAMA versus LABA/ICS fixed-dose combinations in the prevention of COPD exacerbations: a modeling analysis of literature aggregate data
ConclusionsThis study showed that not all LABA/LAMA FDCs were superior to LABA/ICS FDCs in safety and in preventing moderate or severe exacerbations in patients with stable COPD, providing important quantitative information for COPD-related guidelines.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Dipeptidyl-peptidase-4 inhibitors have anti-inflammatory effects in patients with type 2 diabetes
ConclusionThis meta-analysis demonstrated that DPP-4 inhibitors can significantly attenuate low-grade inflammatory state in patients with T2DM. In addition to improving glycemic control, DDP-4 inhibitors might offer extra therapeutic value by controlling inflammation.Graphical Abstract
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Impact of tofogliflozin on hepatic outcomes: a systematic review
ConclusionOverall, an improvement in levels of hepatic parameters was observed in T2DM patients with concurrent liver disorders. However, a large number of clinical trials are needed to prove the efficacy of tofogliflozin on hepatic outcomes in patients with T2DM.
Source: European Journal of Clinical Pharmacology - September 22, 2023 Category: Drugs & Pharmacology Source Type: research
Quality consistency evaluation of chemical composition and pharmacology of Shaoyao-Gancao decoction dispensing granules and traditional decoction
This study presents a method for evaluating the quality consistency of DGCM and TD of SGD, offering novel insights into the evaluation of consistency between DGCM and TD.PMID:37736670 | DOI:10.1002/bmc.5745
Source: Biomedical Chromatography : BMC - September 22, 2023 Category: Biomedical Science Authors: Fengyu Dong Mengdi Xie Manwen Xu Lu Lu Yan Miao Panpan Zhang Xiaopeng Li Xinjing Gui Ruixin Liu Source Type: research
Pop-up screening nested within routine community activities unmasks an addressed cardiovascular risk: A pilot study (Gippsland Healthy Heart Study)
CONCLUSIONS: This study supported the feasibility and effectiveness of pop-up screening to detect CVRF in rural communities.PMID:37735862 | DOI:10.1111/ajr.13042
Source: The Australian Journal of Rural Health - September 22, 2023 Category: Rural Health Authors: Masashi Fujino Julie Butters Mark Boyes Noel Duncan Fleur Streets Amy Sabatini Alan Herschtal Adam J Nelson Stephen J Nicholls Source Type: research
Cytochrome P450 Mediated Cyclization in Eunicellane Derived Diterpenoid Biosynthesis
Angew Chem Int Ed Engl. 2023 Sep 21:e202312490. doi: 10.1002/anie.202312490. Online ahead of print.ABSTRACTTerpene cyclization, one of the most complex chemical reactions in nature, is generally catalyzed by two classes of terpene cyclases (TCs). Cytochrome P450s that act as unexpected TC-like enzymes are known but are very rare. Here, we genome-mined a cryptic bacterial terpenoid gene cluster, named ari, from the thermophilic actinomycete strain Amycolatopsis arida. By employing a heterologous production system, we isolated and characterized three highly oxidized eunicellane derived diterpenoids, aridacins A-C (1-3), that...
Source: Angewandte Chemie - September 22, 2023 Category: Chemistry Authors: Zengyuan Wang Qian Yang Jingyi He Haixin Li Xingming Pan Zining Li Hui-Min Xu Jeffrey Rudolf Dean Tantillo Liao-Bin Dong Source Type: research
Photocatalytic Free Radical-Controlled Synthesis of High-Performance Single-Atom Catalysts
In this study, we present a straightforward approach for preparing SACs utilizing a photocatalytic radical control strategy. Notably, we demonstrate for the first time that radicals generated during the photochemical process effectively hinder the aggregation of individual atoms. By leveraging the cooperative anchoring of nitrogen atoms and crystal lattice oxygen on the support, we successfully stabilize the single atom. Our Pd1/TiO2 catalysts exhibit remarkable catalytic activity and stability in the Suzuki-Miyaura cross-coupling reaction, which was 43 times higher than Pd/C. Furthermore, we successfully depose Pd atoms o...
Source: Angewandte Chemie - September 22, 2023 Category: Chemistry Authors: Xiang Chen Shuhui Guan Jianjiang Zhou Hengjun Shang Jingyuan Zhang Fujian Lv Han Yu Hexing Li Zhenfeng Bian Source Type: research
Benefits and Challenges of Remote Patient Monitoring as Perceived by Health Care Practitioners: A Systematic Review
Conclusion Health care practitioners generally believe that RPM is feasible for application. Additionally, there is a consensus that telemonitoring strategies will become increasingly relevant. However, there are still drawbacks to the technology that need to be considered.PMID:37735970 | DOI:10.7812/TPP/23.022
Source: The Permanente journal - September 22, 2023 Category: General Medicine Authors: Luiza Palmieri Serrano Karla C Maita Francisco R Avila Ricardo A Torres-Guzman John P Garcia Abdullah S Eldaly Clifton R Haider Christopher L Felton Margaret R Paulson Michael J Maniaci Antonio J Forte Source Type: research
Building the Evidence for Exercise in Solid Organ Transplant: How Far Have We Moved the Needle?
Physiother Can. 2023 Sep 19;75(3):209-211. doi: 10.3138/ptc-2022-0111. eCollection 2023 Sep.NO ABSTRACTPMID:37736416 | PMC:PMC10510535 | DOI:10.3138/ptc-2022-0111
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research
Factors Related to Expectations in Individuals Waiting for Total Knee Arthroplasty
CONCLUSIONS: This questionnaire reliably measures patient expectations before TKA; however, further research is needed. Although we anticipated younger age to be related to higher expectations, higher function prior to TKA appears to be more strongly associated with higher expectations.PMID:37736415 | PMC:PMC10510534 | DOI:10.3138/ptc-2020-0141
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Kathleen C Madara Moiyad Aljehani Adam Marmon Steven Dellose James Rubano Joseph Zeni Source Type: research
Evaluating a Wearable Solution for Measuring Lower Extremity Asymmetry During Landing
CONCLUSIONS: Our findings show acceptable agreement between impact acceleration and accelerometer-based COM acceleration and lack of agreement between impact accelerations and accelerometer-based tibial acceleration asymmetries. COM acceleration could be used to quantify landing impacts during rehabilitation, but we do not consider the accelerometer-based asymmetry measures to be a suitable alternative for force plate-based measures. Future work should focus on determining normative values for lower extremity asymmetries during landing tasks.PMID:37736414 | PMC:PMC10510545 | DOI:10.3138/ptc-2021-0086
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Anu M R äisänen Lauren C Benson Jackie L Whittaker Carolyn A Emery Source Type: research
Clinician's Commentary on Nolan et al. < sup > 1 < /sup >
Physiother Can. 2023 Sep 19;75(3):269-270. doi: 10.3138/ptc-2021-0078-cc. eCollection 2023 Sep.NO ABSTRACTPMID:37736413 | PMC:PMC10510542 | DOI:10.3138/ptc-2021-0078-cc
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Suzanne Babyar Source Type: research
La collecte de donn ées probantes sur l’exercice en cas de transplantation d’organe plein : à quel point avons-nous progressé?
Physiother Can. 2023 Sep 19;75(3):212-214. doi: 10.3138/ptc-2022-0111-fr. eCollection 2023 Sep.NO ABSTRACTPMID:37736412 | PMC:PMC10510543 | DOI:10.3138/ptc-2022-0111-fr
Source: Physiotherapy Canada - September 22, 2023 Category: Physiotherapy Authors: Sunita Mathur Tania Janaudis-Ferreira Manoela de Paula Ferreira Nicholas Bourgeois Tom Blydt-Hansen Tracy Fuller Robin Deliva Lorraine Hamiwka Source Type: research
