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Infectious Disease: Outbreaks
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Total 27843 results found since Jan 2013.
Mucormycosis: update on clinical presentation, diagnosis, and treatment
Curr Opin Infect Dis. 2023 Sep 22. doi: 10.1097/QCO.0000000000000976. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Mucormycosis (MCR) is a common opportunistic mold infection, and Mucorales were recently designated by WHO as priority pathogens. The interest in this infection has risen significantly since the major outbreak of MCR in the context of the COVID-19 pandemic, particularly in India. Herein, we summarize recently (last 24 months) published information regarding clinical aspects of MCR.RECENT FINDINGS: The disease remains protean in its clinical presentation, difficult to diagnose, and challenging to treat. In ...
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Natalie J M Dailey Garnes Dimitrios P Kontoyiannis Source Type: research
Countering Mpox Vaccination Disparities in Los Angeles County, California, May-December 2022
Am J Public Health. 2023 Sep 21:e1-e5. doi: 10.2105/AJPH.2023.307409. Online ahead of print.ABSTRACTProviding equitable access to vaccines for individuals at risk for mpox was critical for containing the 2022 mpox outbreak in Los Angeles County, California. Eligible non-Hispanic Black/African American and Latinx individuals had lower vaccine uptake than did non-Hispanic White individuals, despite having higher mpox case rates. Strategies to address disparities in vaccine uptake included using familiar messaging technology to reach individuals at risk for mpox, using partnerships with community-based organizations to raise ...
Source: Am J Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Auguste Brihn Nava Yeganeh Sonali Kulkarni Olivia Moir Saloniki Madrid Mario Perez Rita Singhal Andrea A Kim Source Type: research
pH-dependent conformational change within the Lassa virus transmembrane domain elicits efficient membrane fusion
Biochim Biophys Acta Biomembr. 2023 Sep 19:184233. doi: 10.1016/j.bbamem.2023.184233. Online ahead of print.ABSTRACTLassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although there are annual outbreaks in West Africa, and recently isolated cases worldwide, there are no current therapeutics or vaccines, which poses LASV as a significant global public health threat. One of the key steps in LASV infection is the delivery of its genetic material by fusing its viral membrane with the host cell membrane. This process is facilitated by signi...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Patrick M Keating Nicholas P Schifano Xinrui Wei Matthew Y Kong Jinwoo Lee Source Type: research
Task Force for a rapid response to an outbreak of severe acute hepatitis of unknown aetiology in children in Portugal in 2022
Euro Surveill. 2023 Sep;28(38). doi: 10.2807/1560-7917.ES.2023.28.38.2300171.ABSTRACTOn 5 April 2022, the United Kingdom reported an increase of cases of severe acute hepatitis of unknown aetiology in children, several needing hospitalisation and some required liver transplant or died. Thereafter, 35 countries reported probable cases, almost half of them in Europe. Facing the alert, on 28 April, Portugal created a multidisciplinary Task Force (TF) for rapid detection of probable cases and response. The experts of the TF came from various disciplines: clinicians, laboratory experts, epidemiologists, public health experts an...
Source: Euro Surveill - September 21, 2023 Category: Infectious Diseases Authors: Berta Grau-Pujol Jo ão Vieira Martins Isabel Goncalves Fernanda Rodrigues Rita de Sousa Dina Oliveira Joana Bettencourt Diana Mendes In ês Mateus de Cunha Sara Pocinho Ana Firme Benvinda Estela Dos Santos Andr é Peralta Santos Maria Jo ão Albuquerque Source Type: research
Countering Mpox Vaccination Disparities in Los Angeles County, California, May-December 2022
Am J Public Health. 2023 Sep 21:e1-e5. doi: 10.2105/AJPH.2023.307409. Online ahead of print.ABSTRACTProviding equitable access to vaccines for individuals at risk for mpox was critical for containing the 2022 mpox outbreak in Los Angeles County, California. Eligible non-Hispanic Black/African American and Latinx individuals had lower vaccine uptake than did non-Hispanic White individuals, despite having higher mpox case rates. Strategies to address disparities in vaccine uptake included using familiar messaging technology to reach individuals at risk for mpox, using partnerships with community-based organizations to raise ...
Source: American Journal of Public Health - September 21, 2023 Category: International Medicine & Public Health Authors: Auguste Brihn Nava Yeganeh Sonali Kulkarni Olivia Moir Saloniki Madrid Mario Perez Rita Singhal Andrea A Kim Source Type: research
Prevalence of Type III Secretion System (T3SS) and Biofilm Development in Genetically Heterogeneous Clinical Isolates of Pseudomonas aeruginosa from Nigeria
This study examined 430 clinical isolates from our previous work, comprising 181 MDR (multidrug-resistant) and 249 non-MDR isolates. Biofilm production and type III secretion toxins were determined using colorimetric microtiter plate assay and polymerase chain reaction, respectively. Carbapenem-resistant isolates were typed using REP-PCR and BOX-PCR. Biofilm production was detected in 386/430 (89.8%) of the isolates. Out of 386 biofilm producers, 167 (43.3%) were multidrug-resistant isolates. PCR identified four T3SS virulence types among 430 isolates, including 78 (18.1%) exoU+/exoS- isolates, 343 (79.8%) exoU-/exoS + iso...
Source: Current Microbiology - September 21, 2023 Category: Microbiology Authors: Oluwatoyin B Olaniran Ahmed Donia Olufemi E Adeleke Habib Bokhari Source Type: research
Unique Presentations of Burkholderia gladioli Infections in Several Strains of Immunocompromised Mice
Comp Med. 2023 Sep 20. doi: 10.30802/AALAS-CM-23-000016. Online ahead of print.ABSTRACTFour strains of experimentally naïve mice (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ [NSG], NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ[NRG], B6.129S(Cg)-Stat1tm1Dlv/J [STAT1-/-], and B6.129S7-Ifngr1tm1Agt/J [IFNγR-/-] housed in a barrier facility developedunusual and seemingly unrelated clinical signs. Young NSG/NRG mice (n = 49, mean age = 4 ± 0.4 mo) exhibited nonspecificclinical signs of moderate-to-severe lethargy, hunched posture, decreased body condition, and pallor. In contrast to the NSG/NRGmice, the STAT1-/- and IFNγR-/-mice (n = 5) developed...
Source: Comparative Medicine - September 20, 2023 Category: Zoology Authors: Andrea J Osborne Sarah E Clark Tiffany L Whitcomb Penny L Devlin Matthew R Lanza Hannah M Atkins Source Type: research
What evidence for a cholera vaccine? Jaime Ferr án's submissions to the Prix Bréant
This article analyses how the French Academy of Sciences assessed Jaime Ferrán's cholera vaccine submitted for the Prix Bréant in the 1880s. Ferrán, a Spanish independent physician, discovered the treatment in 1884 and tried it on thousands of patients during the cholera outbreak in Valencia the following year. His evaluation sparked a controversy in Spain and abroad on the vaccine's efficacy. The Bréant jury did not see any evidence for it in Ferrán's submission, a decision usually interpreted in terms of French scientific nationalism (or simple chauvinism): an outsider from the scientific periphery could not be awar...
Source: Medical History - September 19, 2023 Category: History of Medicine Authors: Clara Uzcanga David Teira Source Type: research
A Review on the Antibiotic Resistance of < em > Shigella < /em > Strains in Iran
Infect Disord Drug Targets. 2023 Aug 31. doi: 10.2174/1871526523666230811093114. Online ahead of print.ABSTRACTShigella infection is commonly related to diarrhea and has been a noteworthy source of morbidity and mortality worldwide. There is a wide range of symptoms associated with these contagious microorganisms, from watery diarrhea to fulminant dysentery manifesting with recurrent bloody stools, fever, and prostration. While the mortality rate from Shigellosis has decreased significantly during the past three decades, it remains a principal cause of death in the world. The use of antibiotics in Shigella treatment remark...
Source: Infectious Disorders Drug Targets - September 19, 2023 Category: Infectious Diseases Authors: Mahdi Shooraj Marziye Taheri Mohammadmahdi Karimi-Yazdi Source Type: research
Prevalence of multi-antimicrobial resistant non-typhoidal Salmonella isolated from filth flies at wet markets in Klang, Malaysia, and their survival in the simulated gastric fluid
This study aims to investigate the prevalence of antimicrobial-resistant NTS, especially Salmonella Enteritidis and S. Typhimurium harboured by filth flies at wet markets, and investigate their survival in the simulated gastric fluid (SGF). Filth flies (n = 90) were captured from wet markets in Klang, Malaysia, and processed to isolate Salmonella spp. The isolates (n = 16) were identified using the multiplex-touchdown PCR and assessed their antimicrobial susceptibility against 11 antimicrobial agents. Finally, three isolates with the highest MAR index were subjected to SGF survival tests. It was observed that 17.8 % of fli...
Source: International Journal of Food Microbiology - September 18, 2023 Category: Food Science Authors: Pratheep Sandrasaigaran Shuvarnah Mohan Nithiyha Sandara Segaran Tze Yan Lee Son Radu Hanan Hasan Source Type: research
Tinea capitis outbreak and other superficial mycosis in an urban community of Medell ín
Conclusion. Tinea capitis was the most common clinical form, and M. canis was the most frequently isolated species. The use of steroids as the first and only option for empiric treatment was worth of notice. The findings of this study point out the importance of microbiological diagnosis in choosing the best treatment for the patients.PMID:37721904 | DOI:10.7705/biomedica.6900
Source: Biomedica : Revista del Instituto Nacional de Salud - September 18, 2023 Category: International Medicine & Public Health Authors: Nelson Andr és Sterling Duban Andr és Rincón Sebasti án Barrera Erika Andrea S ánchez Diana Yuledi Molina Martha Eugenia Ur án Mar ía Del Pilar Jiménez Source Type: research
