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Piloting a shared decision-making clinician training intervention in maternity care in Australia: A mixed methods study
CONCLUSION: Shared decision-making training supports maternity clinicians in developing skills that implement woman-centred care in the timing of planned birth.PMID:37717344 | DOI:10.1016/j.midw.2023.103828
Source: Midwifery - September 17, 2023 Category: Midwifery Authors: Teena Clerke Jayne Margetts Helen Donovan Heather L Shepherd Angela Makris Alison Canty Annette Ruhotas Christine Catling Amanda Henry Source Type: research

How do new runners maintain their running, and what leads to others stopping? A qualitative, longitudinal study
Psychol Sport Exerc. 2023 Aug 23;70:102515. doi: 10.1016/j.psychsport.2023.102515. Online ahead of print.ABSTRACTMany people who start running do not maintain their behaviour change. We used qualitative, longitudinal methods to explore and interpret the experiences of new runners and answer the question, "What experiences explain how new runners maintain their running or explain why they stop?" We interviewed 20 new runners (all White British, 14 women, 6 men) about their experiences; we interviewed 10 until they stopped running and 10 until they maintained running for 6-12 months (65 interviews in total). We also conducte...
Source: Psychology of Sport and Exercise - September 17, 2023 Category: Sports Medicine Authors: Alister McCormick Pille Pedmanson Ben Jane Paula Watson Source Type: research

Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations
Regul Toxicol Pharmacol. 2023 Sep 15:105493. doi: 10.1016/j.yrtph.2023.105493. Online ahead of print.ABSTRACTLike many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it is necessary to carry out a safety evaluation process, quantifying risks so that they can be properly managed. A workshop on this topic in 2022 discussed how best to undertake quantitative risk assessment (QRA) for pestici...
Source: Regulatory Toxicology and Pharmacology : RTP - September 17, 2023 Category: Toxicology Authors: Olivier Sanvido David A Basketter Aur élie Berthet Denise Bloch Janine Ezendam Nancy B Hopf Nicole Kleinstreuer Leona L Merolla Wolfgang Uter Christiane Wiemann Martin F Wilks Source Type: research

Piloting a shared decision-making clinician training intervention in maternity care in Australia: A mixed methods study
CONCLUSION: Shared decision-making training supports maternity clinicians in developing skills that implement woman-centred care in the timing of planned birth.PMID:37717344 | DOI:10.1016/j.midw.2023.103828
Source: Midwifery - September 17, 2023 Category: Midwifery Authors: Teena Clerke Jayne Margetts Helen Donovan Heather L Shepherd Angela Makris Alison Canty Annette Ruhotas Christine Catling Amanda Henry Source Type: research

Steroid hormone signaling: What we can learn from insect models
Vitam Horm. 2023;123:525-554. doi: 10.1016/bs.vh.2022.12.006. Epub 2023 Feb 6.ABSTRACTEcdysteroids are a group of steroid hormones in arthropods with pleiotropic functions throughout their life history. Ecdysteroid research in insects has made a significant contribution to our current understanding of steroid hormone signaling in metazoans, but how far can we extrapolate our findings in insects to other systems, such as mammals? In this chapter, we compare steroid hormone signaling in insects and mammals from multiple perspectives and discuss similarities and differences between the two lineages. We also highlight a few un...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Naoki Okamoto Daiki Fujinaga Naoki Yamanaka Source Type: research

Quantitative risk assessment of skin sensitising pesticides: Clinical and toxicological considerations
Regul Toxicol Pharmacol. 2023 Sep 15;144:105493. doi: 10.1016/j.yrtph.2023.105493. Online ahead of print.ABSTRACTLike many other consumer and occupational products, pesticide formulations may contain active ingredients or co-formulants which have the potential to cause skin sensitisation. Currently, there is little evidence they do, but that could just reflect lack of clinical investigation. Consequently, it is necessary to carry out a safety evaluation process, quantifying risks so that they can be properly managed. A workshop on this topic in 2022 discussed how best to undertake quantitative risk assessment (QRA) for pes...
Source: Regulatory Toxicology and Pharmacology : RTP - September 17, 2023 Category: Toxicology Authors: Olivier Sanvido David A Basketter Aur élie Berthet Denise Bloch Janine Ezendam Nancy B Hopf Nicole Kleinstreuer Leona L Merolla Wolfgang Uter Christiane Wiemann Martin F Wilks Source Type: research

Divergences in color perception between deep neural networks and humans
Cognition. 2023 Sep 14;241:105621. doi: 10.1016/j.cognition.2023.105621. Online ahead of print.ABSTRACTDeep neural networks (DNNs) are increasingly proposed as models of human vision, bolstered by their impressive performance on image classification and object recognition tasks. Yet, the extent to which DNNs capture fundamental aspects of human vision such as color perception remains unclear. Here, we develop novel experiments for evaluating the perceptual coherence of color embeddings in DNNs, and we assess how well these algorithms predict human color similarity judgments collected via an online survey. We find that stat...
Source: Cognition - September 16, 2023 Category: Neurology Authors: Ethan O Nadler Elise Darragh-Ford Bhargav Srinivasa Desikan Christian Conaway Mark Chu Tasker Hull Douglas Guilbeault Source Type: research

Accommodating Students with Disabilities: Fieldwork Educators' Experiences
Conclusion. Fieldwork educators can work with students to align their accommodations with required learning outcomes for professional practice and use their occupational therapy skills to assist with implementation. Fieldwork educators require time and other supports to work effectively with all students.PMID:37715626 | DOI:10.1177/00084174231201703
Source: Canadian Journal of Occupational Therapy - September 16, 2023 Category: Occupational Health Authors: Shaminder K Dhillon Sandra E Moll Magda Stroinska Patricia E Solomon Source Type: research

An interval water demand prediction method to reduce uncertainty: A case study of Sichuan Province, China
In this study, we constructed a GA-BP-KDE hybrid interval water demand prediction model by combining non-parametric estimation and point prediction. Multiple metaheuristic algorithms were used to optimize the Back-Propagation Neural Network (BP) and Kernel Extreme Learning Machine (KELM) network structures. The performance of the water demand point prediction models was compared by the Root Mean Squared Error (RMSE), Mean Absolute Percentage Error (MAPE), Kling-Gupta Efficiency (KGE), computation time, and fitness convergence curves. The kernel density estimation method (KDE) and the normal distribution method were used to...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Xinyu Xia Bin Liu Rui Tian Zuli He Suyue Han Ke Pan Jingjing Yang Yiting Zhang Source Type: research

Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3 β/β-catenin signaling in Wistar rats
This study aimed at investigating the effects of chronic treatment with amisulpride (5 mg/kg/day) in the management of 5-fluorouracil (5-FU)-induced cognitive deficits in Wistar rats. Rats received 5 intraperitoneal injections of 5-FU (25 mg/kg every 3 days). 5-FU treatment induced impairments in spatial learning (reduction in object location discrimination ratio) and non-spatial learning (reduction in novel object recognition discrimination ratio). Moreover, 5-FU induced a decrease in the activity of the Wnt/GSK-3β/β-catenin pathway with a decrease in brain-derived neurotrophic factor (BDNF) level in the hippocampus. Th...
Source: International Immunopharmacology - September 16, 2023 Category: Allergy & Immunology Authors: Radwa S Raafat Mohamed Z Habib Amany A AbdElfattah Nouran K Olama Sahar M Abdelraouf Nevien Hendawy Khaled A Kamal Salwa A Nawishy Sawsan Aboul-Fotouh Source Type: research

A Model of the Home Literacy Environment and Family Risk of Reading Difficulty in Relation to Children's Preschool Emergent Literacy
This study extends the research on the preschool home literacy environment (HLE) in the context of the family risk (FR) of reading disability (RD) by examining a multiple-deficit model of RD. A total of 1171 six-year-old children were assessed at school entry, the onset of formal reading instruction in Norway. Their parents completed a questionnaire regarding their own RD, education, and the HLE. The final sample after applying the inclusion criteria was 794 children and their parents. The findings suggest, first, that two HLE factors (access to print and reading-related activities) should be distinguished rather than trea...
Source: Journal of Learning Disabilities - September 16, 2023 Category: Disability Authors: Sara Esmaeeli Source Type: research

Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
CONCLUSIONS: We have developed a GPCR-TME classifier that could predict the OS and immunotherapy response of patients with melanoma highly effectively based on multi-omics analysis.PMID:37716991 | DOI:10.1186/s40001-023-01346-6
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Kangjie Shen Qiangcheng Wang Lu Wang Yang Yang Min Ren Yanlin Li Zixu Gao Shaoluan Zheng Yiteng Ding Jiani Ji Chenlu Wei Tianyi Zhang Yu Zhu Jia Feng Feng Qin Yanwen Yang Chuanyuan Wei Jianying Gu Source Type: research

Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation & amp; Quality (IQ) Consortium Perspective on Use Cases and Best Practices
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3053. Online ahead of print.ABSTRACTRecent breakthroughs in Artificial Intelligence (AI) and Machine Learning (ML) have ushered in a new era of possibilities across various scientific domains. One area where these advancements hold significant promise is model-informed drug discovery and development (MID3). To foster a wider adoption and acceptance of these advanced algorithms, the Innovation & Quality (IQ) Consortium initiated the AI/ML working group (WG) in 2021 with the aim of promoting their acceptance among the broader scientific community as well as by regulatory...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Nadia Terranova Didier Renard Mohamed H Shahin Sujatha Menon Youfang Cao Cornelis E C A Hop Sean Hayes Kumpal Madrasi Sven Stodtmann Thomas Tensfeldt Pavan Vaddady Nicholas Ellinwood James Lu Source Type: research

Evaluation of a pilot to introduce simulated learning activities to support speech and language therapy students' clinical development
CONCLUSIONS & IMPLICATIONS: Student experience of simulation was positive. One of the key elements students found to support their clinical skills was the importance of the safe space; support for learning instead of correction led them to engage in active learning. Key barriers to simulation related to having sufficient prior knowledge, the skills of the facilitator, group size and the wider learning landscape of the programme. In response to this pilot, there are plans to continue developing this model of simulation and embed simulation across the programme, led by a sound pedagogical approach with clear preparation and ...
Source: International Journal of Language and Communication Disorders - September 16, 2023 Category: Speech-Language Pathology Authors: Emma Ormerod Claire Mitchell Source Type: research