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Research Progress of Metformin in the Treatment of Oral Squamous Cell Carcinoma
Endocrinology. 2023 Sep 20:bqad139. doi: 10.1210/endocr/bqad139. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC) is one of the most common malignancies with high mortality, posing a great threat to both human physical and mental health. With the advancement of scientific research, a variety of cancer therapies have been used for OSCC treatment. However, the prognosis of OSCC shows no significant improvement. Metformin has been recognized as the first-line drug for the treatment of diabetes, and recent studies have shown that metformin has a remarkable suppressive effect on tumor progression. Metformin can...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Jiayi Liu Jing Zhao Xue Qiao Source Type: research

Non-surgical management in children with non-refluxing primary megaureter: a systematic review and meta-analysis
ConclusionsThe low pooled prevalence of secondary surgical intervention and high pooled prevalence of resolution may support the current non-surgical management in children with non-refluxing primary megaureter. However, these results should be interpreted cautiously due to the limited available body of evidence. Future studies should overcome existing limitations of imaging methods by using standardized, comparable criteria and report outcome parameters in a quantitative manner. This would allow more sufficient data synthesis to provide evidence-based recommendations for clinical decision-making and counseling.Systematic ...
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Clinical trials in Charcot-Marie-Tooth disorders: a retrospective and preclinical assessment
ConclusionCurrent CMT trials are exploring procedural and molecular therapeutic options with substantial participation of the pharmaceutical industry worldwide. Emerging drug therapies directed at molecular pathogenesis are being advanced in human clinical trials; however, the majority remain within animal investigations.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

The increasing complexity of arbovirus serology: An in-depth systematic review on cross-reactivity
by Louella M. R. Kasbergen, David F. Nieuwenhuijse, Erwin de Bruin, Reina S. Sikkema, Marion P. G. Koopmans Diagnosis of arbovirus infection or exposure by antibody testing is becoming increasingly difficult due to global expansion of arboviruses, which induce antibodies that may (cross-)react in serological assays. We provide a systematic review of the current knowledge and knowledge gaps in differential arbovirus serology. The search included Medline, Embase and Web of Science databases and identified 911 publications which were reduced to 102 after exclusion of studies not providing data on possible cross-reactivity or...
Source: PLoS Neglected Tropical Diseases - September 22, 2023 Category: Tropical Medicine Authors: Louella M. R. Kasbergen Source Type: research

Reflex syncope in the UK Armed Forces
Conclusions These data are the first to define the incidence and prevalence of syncope in the UKAF. Orthostasis and heat are probable triggers, although recruits are potentially protected. These data offer opportunities to improve the health and well-being of SP, with economic, logistical and reputational benefits for the UKAF. Further research to identify personnel at risk of future syncopal events may allow for targeted use of countermeasures.
Source: Journal of the Royal Army Medical Corps - September 22, 2023 Category: General Medicine Authors: Parsons, I., Ellwood, J., Stacey, M. J., Gall, N., Grundy-Bowers, M., Chowienczyk, P., Woods, D. Tags: Original research Source Type: research

A Systematic Review of Methodologies Used in Models of the Treatment of Diabetes Mellitus
ConclusionsModels developed in the past 12 years for health economic evaluations of diabetes treatments are of high-quality and make use of advanced methods. However, further developments are needed to improve the statistical modelling component of cost-effectiveness models and to provide better assessment of structural uncertainty.
Source: PharmacoEconomics - September 22, 2023 Category: Health Management Source Type: research

Evaluation of pharyngeal airway volume three-dimensionally in various sagittal skeletal patterns - Systematic review
This study was prepared according to the Cochrane criteria for creating a systematic review and meta-analysis and confirms the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. This search was conducted to answer the patient/population, intervention, comparison and outcomes (PICO) question: To evaluate (outcome) and compare (comparison) whether there is a difference in airway volume in patients (participants) with different skeletal malocclusions diagnosed using 3D data (intervention).The first two authors extracted the data from the included studies and assessed the risk of bias in the...
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Balaji Rajkumar Ratna Parameswaran Mary Sanjana Srinivasan Boovaraghavan Devaki Vijayalakshmi Source Type: research

Electronic cigarettes: Ally or an enemy in combating tobacco-use-associated diseases - An integrative review
Conclusion: Although ECs are less harmful than TCs in combustible inhaled constituents, their long-term safety can still not be ascertained due to the scarcity of long-term studies and conflicting results.
Source: Indian Journal of Dental Research - September 22, 2023 Category: Dentistry Authors: Hunny Sharma Manisha Ruikar Source Type: research

IJERPH, Vol. 20, Pages 6804: Seeking Health in a Digital World: Exploring Immigrant Parents & rsquo; Quest for Child Health Information & mdash;A Scoping Review
IJERPH, Vol. 20, Pages 6804: Seeking Health in a Digital World: Exploring Immigrant Parents’ Quest for Child Health Information—A Scoping Review International Journal of Environmental Research and Public Health doi: 10.3390/ijerph20196804 Authors: Annina E. Zysset Patricia Schwärzler Julia Dratva During pregnancy and early parenthood, parents’ strong interest in pediatric health information presents a valuable opportunity to positively impact long-term health-seeking behavior and overall child health. In line with the increasing prevalence of digital transformation, a scoping ...
Source: International Journal of Environmental Research and Public Health - September 22, 2023 Category: Environmental Health Authors: Annina E. Zysset Patricia Schw ärzler Julia Dratva Tags: Systematic Review Source Type: research

Cancers, Vol. 15, Pages 4680: Health-Related Quality of Life Outcomes in Meningioma Patients Based upon Tumor Location and Treatment Modality: A Systematic Review and Meta-Analysis
S. D’Amico Patients with meningiomas may have reduced health-related quality of life (HRQoL) due to postoperative neurological deficits, cognitive dysfunction, and psychosocial burden. Although advances in surgery and radiotherapy have improved progression-free survival rates, there is limited evidence regarding treatment outcomes on HRQoL. This review examines HRQoL outcomes based on tumor location and treatment modality. A systematic search in PubMed yielded 28 studies with 3167 patients. The mean age was 54.27 years and most patients were female (70.8%). Approximately 78% of meningiomas were located in the skull ...
Source: Cancers - September 22, 2023 Category: Cancer & Oncology Authors: Ali San Raphia K. Rahman Praveen Sanmugananthan Michael D. Dub é Nicholas Panico Ogechukwu Ariwodo Vidur Shah Randy S. D ’Amico Tags: Systematic Review Source Type: research

Should we suspect primary aldosteronism in patients with hypokalaemic rhabdomyolysis? A systematic review
Severe hypokalaemia causing rhabdomyolysis (RML) in primary aldosteronism (PA) is a rare entity, and only a few cases have been reported over the last four decades. This systematic review and case report aims to gather all published data regarding a hypokalaemic RML as presentation of PA in order to contribute to the early diagnosis of this extremely rare presentation. With the use of PubMed Central, EMBASE, and Google Scholar, a thorough internet-based search of the literature was conducted to identify articles and cases with RML secondary to hypokalaemia due to PA between June 1976 and July 2023. The case study concerns ...
Source: Frontiers in Endocrinology - September 22, 2023 Category: Endocrinology Source Type: research

Genuine Memory Deficits as Assessed by the Free and Cued Selective Reminding Test (FCSRT) in the Behavioural Variant of Frontotemporal Dementia. A Systematic Review and Meta-analysis Study
AbstractThe current diagnostic criteria for the behavioural variant of frontotemporal dementia (bvFTD) foresee a relative sparing of long-term memory. Although bvFTD patients were thought to report secondary memory deficits associated with prefrontal dysfunctions, some studies indicated the presence of a “genuine memory deficit” related to mesial temporal lobe dysfunctions. Among various neuropsychological tests, the Free and Cue Selective Reminding Test (FCSRT) has been recommended to distinguish genuine from apparent amnesia. We conducted a systematic review and a random effect Bayesian meta-a nalysis to evaluate the...
Source: Neuropsychology Review - September 22, 2023 Category: Neuroscience Source Type: research

Sleep in marathon and ultra-marathon runners: A brief narrative review
Conclusions: In summary, the longer the distance of a running race, the greater the importance of an optimal sleep for race performance as well as the impact of a race on sleep.
Source: Frontiers in Neurology - September 22, 2023 Category: Neurology Source Type: research

Sex difference in alcohol withdrawal syndrome: a scoping review of clinical studies
ConclusionDespite the significant heterogeneity of the studies selected and the lack of a focus on investigating potential sex differences, this review of clinical studies on AWS suggests that men and women exhibit different AWS manifestations. Large-scale studies focusing specifically on investigating sex difference in AWS are needed.
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research

Cardiovascular adverse reactions associated with escitalopram in patients with underlying cardiovascular diseases: a systematic review and meta-analysis
ConclusionEscitalopram does not significantly increase the risk of cardiovascular adverse reactions compared with placebo in patients with underlying cardiovascular disease. However, the presence of wide CIs and the limited number of included studies highlight the need for further studies with larger sample sizes to enhance the precision and reliability of these findings.Systematic review registration: International Prospective Register of Systematic Reviews [CRD42022298181].
Source: Frontiers in Psychiatry - September 22, 2023 Category: Psychiatry Source Type: research