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A deep learning-based approach for rectus abdominis segmentation and distance measurement in ultrasonography
Conclusion: Deep learning model Res-UNet has good reliability in RA segmentation and distance measurement in ultrasound images, with great potential in the clinical diagnosis of DRA.PMID:37736487 | PMC:PMC10509763 | DOI:10.3389/fphys.2023.1246994
Source: Physiological Research - September 22, 2023 Category: Physiology Authors: Fei Wang Rongsong Mao Laifa Yan Shan Ling Zhenyu Cai Source Type: research
The role of LOXL2 induced by glucose metabolism-activated NF- κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
J Mol Med (Berl). 2023 Sep 22. doi: 10.1007/s00109-023-02369-6. Online ahead of print.ABSTRACTGemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the effectiveness of chemotherapy and increases the rate of recurrence. Lysyl oxide-like 2 (LOXL2) is highly expressed in pancreatic cancer and is involved in carcinogenesis and EMT regulation. However, studies on the role of LOXL2 in drug resistance are limited. Here, we investigated the mechanism of LOXL2 induction and the effect of LOXL2 on EMT and CSC in gemcitabine-resistant pancreatic cancer. Glucose metabolism...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Yun Sun Lee Hyung Sun Kim Hyo Jung Kim Hyeon Woong Kang Da Eun Lee Myeong Jin Kim Woosol Chris Hong Ju Hyun Kim Minsoo Kim Jae-Ho Cheong Joon Seong Park Source Type: research
Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research
Utility of FRET in studies of membrane protein oligomerization: the concept of the effective dissociation constant
Biophys J. 2023 Sep 21:S0006-3495(23)00588-X. doi: 10.1016/j.bpj.2023.09.011. Online ahead of print.ABSTRACTThe activity of many membrane receptors is controlled through their lateral association into dimers or higher order oligomers. While Förster resonance energy transfer (FRET) measurements have been used extensively to characterize the stability of receptor dimers, the utility of FRET in studies of larger oligomers has been limited. Here we introduce an effective equilibrium dissociation constant that can be extracted from FRET measurements for EphA2, a receptor tyrosine kinase (RTK) known to form active oligomers of ...
Source: Biophysical Journal - September 22, 2023 Category: Physics Authors: Daniel McKenzie Daniel Wirth Taras V Pogorelov Kalina Hristova Source Type: research
Attention-gated U-Net networks for simultaneous axial/sagittal planes segmentation of injured spinal cords
This study proposes a new CNN-based segmentation method in which information is exchanged between two networks analyzing the scans from different planes. Our aim was to develop a robust method for automatic segmentation of the spinal cord in patients having suffered traumatic injuries. The database consisted of 106 sagittal MRI scans from 94 patients with traumatic spinal cord injuries. Our method used an innovative approach where the scans were analyzed in series under the axial and sagittal plane by two different convolutional networks. The results were compared with those of Deepseg 2D from the Spinal Cord Toolbox (SCT)...
Source: Journal of Applied Clinical Medical Physics - September 22, 2023 Category: Physics Authors: Nicolas Masse-Gignac Salom ón Flórez-Jiménez Jean-Marc Mac-Thiong Luc Duong Source Type: research
Initial experience with an electron FLASH research extension (FLEX) for the Clinac system
CONCLUSION: Our studies characterized the non-clinical Clinac-FLEX system as a viable solution to conduct FLASH research that could substantially increase access to ultra-high-dose-rate capabilities for scientists.PMID:37735808 | DOI:10.1002/acm2.14159
Source: Journal of Applied Clinical Medical Physics - September 22, 2023 Category: Physics Authors: Kyuhak Oh Kyle J Gallagher Megan Hyun Diane Schott Sarah Wisnoskie Yu Lei Samuel Hendley Jeffrey Wong Shuo Wang Brendan Graff Christopher Jenkins Frank Rutar Md Ahmed Joshua McNeur Jeffrey Taylor Marty Schmidt Lasitha Senadheera Wendy Smith Donald Umstadt Source Type: research
Electrochemical biostimulation of aerobic metabolic TCE degradation in a bioaugmentation approach
In this study, a combined bio-/electro-approach to stimulate the TCE degradation by the SF culture was investigated in laboratory experiments. Column experiments were set up to compare a bioaugmentation approach with an electrochemical biostimulated bioaugmentation approach. Low strength direct current increased the amount of degraded TCE to about 150 % of the control. Through lowering the inflow concentration of oxygen, the effect of the electro-biostimulation in a low oxygen setting confirmed the potential of the bio-electro process for treatment of oxygen-deprived, TCE-contaminated sites.PMID:37735338 | DOI:10.1007/s11356-023-29839-1
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: Steffen Hertle Nick de Boni Heico Schell Andreas Tiehm Source Type: research
Quantifying the impact of green growth and digital transformation on health: new insights from Asian economies
Environ Sci Pollut Res Int. 2023 Sep 22. doi: 10.1007/s11356-023-29595-2. Online ahead of print.ABSTRACTIn today's global landscape, a paradigm shift from closed systems to open and digital networks is underway, with digital transformation and green growth permeating every facet of society, including healthcare. Therefore, our study attempts to explore the impact of digital transformation and green growth on the health outcomes of Asian economies. Employing the ARDL-PMG methodology, we delve into the long-run and short-run correlations between digital transformation, green growth, and health. Digital transformation is capt...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: Wenxin Wang Hong Jiang Ayza Shoukat Burkhanov Aktam Usmanovich Source Type: research
Study on the formation process and mechanism of aerobic granular sludge in the sequencing batch biofilter granular reactor
This study systematically investigated the formation process and mechanism of aerobic granular sludge in an SBBGR to provide a theoretical basis for optimizing the culture of aerobic granular sludge. Aerobic granular sludge with good performance was successfully cultivated after 40 days of incubation using synthetic wastewater as feed: the mixed liquid suspended solids and mixed liquor volatile suspended solids increased from 3.85 and 1.85 g/L to 31.38 and 24.74 g/L respectively, and the COD, TN, and TP removal efficiencies were 91.21%, 84.99%, and 58.14%, respectively. The experimental results showed that Amoebacteria and...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: Ling Lin Shuangshuang Chen Yi Hou Lirong Lei Source Type: research
Association of urinary bisphenols with thyroid function in the general population: a cross-sectional study of an industrial park in China
The objectives of this study are to describe demographic characteristics, BP exposure levels, and thyroid function measurements in potentially exposed and control districts and to investigate the association of urinary BPs with thyroid function. Data were collected from a general population aged 3-79 years (N = 281) recruited by the Zhejiang Human Biomonitoring Program (ZJHBP). The concentrations of 10 kinds of BPs in urine and serum free triiodothyronine (FT3), total triiodothyronine (TT3), free thyroxine (FT4), total thyroxine (TT4), thyroid-stimulating hormone (TSH), thyroglobulin (Tg), thyroglobulin antibodies (TgAb), ...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: Yang Hu Shiming Lai Ying Li Xiaodong Wu Mingluan Xing Xueqing Li Dandan Xu Yuan Chen Jie Xiang Ping Cheng Xiaofeng Wang Zhijian Chen Hao Ding Peiwei Xu Xiaoming Lou Source Type: research
Adsorptive exclusion of crystal violet dye using barium encapsulated alginate/carbon composites: characterization and adsorption modeling studies
Environ Sci Pollut Res Int. 2023 Sep 22. doi: 10.1007/s11356-023-29894-8. Online ahead of print.ABSTRACTThe present study is devoted to the removal of crystal violet dye using the synthesized barium alginate/carbon composites abbreviated as BA (barium alginate), BAAC (barium alginate/activated carbon), BASC (barium alginate/starch carbon), and BASSC (barium alginate/starch carbon modified with CTAB). The adsorptive removal of crystal violet as a function of contact time, pH of solution, composite dose, initial dye concentration, and temperature was studied. The uptake of crystal violet (CV) dye for the composites was recor...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: Sivasankar Venkataraman Vinitha Viswanathan Sunitha Ganesan Thangaiah Kiyoshi Omine Prabhakaran Mylsamy Source Type: research
Impact of green digital finance on green economic recovery and green agricultural development: implications for green environment
This study explores the potential of green digital finance and green agricultural growth to contribute to the green economic recovery of the BRICS economies. We examine the relationship between these variables using empirical data and various statistical techniques, including vector error correction, co-integration, unit root tests and long-run analysis. Our results suggest that well-functioning financial institutions play a crucial role in facilitating the structural transformation of green digital finance and promoting green agricultural growth to achieve green economic recovery in the BRICS region. Our findings undersco...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: BaiHui Wang KaiJie Zhang Source Type: research
Phytotoxicity of coal waste elutriates (Douro Coalfield, North Portugal) in Lactuca sativa
This study aims to assess the ecotoxicological effects of 25 soil elutriates from these different soil types in seed germination and individual (emergence, growth, and morphologic alterations) and subindividual parameters in Lactuca sativa. The different evaluated endpoints were differently affected regarding the soil elutriate revealing the high heterogeneity of soil characteristics. The presence of different potentially toxic elements (e.g., Cd, Cr, Pb, Zn) in soil elutriates, even in low concentrations, caused effects on L. sativa development. Unburned coal wastes and downhill soil elutriates were able to inhibit the ge...
Source: Environmental Science and Pollution Research International - September 22, 2023 Category: Environmental Health Authors: B árbara S Diogo Aracelis Narayan Catarina Mansilha Jorge Espinha Marques Deolinda Flores Sara C Antunes Source Type: research
Large-view x-ray imaging for medical applications using the world's only vertically polarized synchrotron radiation beam and a single asymmetric Si crystal
Phys Med Biol. 2023 Sep 22;68(19). doi: 10.1088/1361-6560/acf640.ABSTRACTObjective.X-ray microangiography provides detailed information on the internal structure and function of a biological subject. Its ability to evaluate the microvasculature of small animals is useful for acquiring basic and clinical medical knowledge. The following three conditions are necessary to attain detailed knowledge of biological functions: (1) high temporal resolution with sufficient x-ray intensity, (2) high spatial resolution, and (3) a wide field of view. Because synchrotron radiation microangiography systems provide high sapatial resolutio...
Source: Physics in Medicine and Biology - September 22, 2023 Category: Physics Authors: Chika Kamezawa Kazuyuki Hyodo Chiho Tokunaga Toru Tsukada Shonosuke Matushita Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
