Large-view x-ray imaging for medical applications using the world's only vertically polarized synchrotron radiation beam and a single asymmetric Si crystal

Phys Med Biol. 2023 Sep 22;68(19). doi: 10.1088/1361-6560/acf640.ABSTRACTObjective.X-ray microangiography provides detailed information on the internal structure and function of a biological subject. Its ability to evaluate the microvasculature of small animals is useful for acquiring basic and clinical medical knowledge. The following three conditions are necessary to attain detailed knowledge of biological functions: (1) high temporal resolution with sufficient x-ray intensity, (2) high spatial resolution, and (3) a wide field of view. Because synchrotron radiation microangiography systems provide high sapatial resolution and high temporal resolution as a result of their high x-ray intensity, such systems have been developed at various synchrotron radiation facilities, starting with the photon factory, leading to numerous medical discoveries. However, the three aforementioned functions are incompatible with the use of synchrotron radiation because the x-ray intensity decreases when a wide field of view is obtained. To overcome these problems, we developed a new x-ray optical system for microangiography in rats using synchrotron radiation x-rays.Approach.Instead of using monochromatic synchrotron radiation x-rays with a conventional double-crystal monochromator, we used white synchrotron radiation x-rays and an asymmetric Si crystal to simultaneously monochromatize the beam and widen the field of view.Main results.The intensity profile and spatial resolution of the x-ray ima...

Source: Physics in Medicine and Biology - September 22, 2023 Category: Physics Authors: Chika Kamezawa Kazuyuki Hyodo Chiho Tokunaga Toru Tsukada Shonosuke Matushita Source Type: research