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Total 69 results found since Jan 2013.

Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research

Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses
In conclusion, our study indicated that 3 weeks antibiotic administration induced elevated expression of many cytokines in mouse colon, suggesting that there might be a direct interaction between antibiotics and host tissue. Furthermore, different antibiotics used can lead to different effects on mouse models. Broad spectrum antibiotic enrofloxacin had a stronger effect on the cytokines response in the colon. Vancomycin can induce significant changes in composition and metabolic profiling of gut microbiota. Compared to enrofloxacin and vancomycin, polymixin B sulfate had a weakest effect. The differences observed in compos...
Source: Frontiers in cellular and infection microbiology - April 23, 2019 Category: Microbiology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Patients often avoid vaccinations due to fear of side effects
Social media may fuel misconceptions over vaccinations Related items fromOnMedica Double check patients with ‘penicillin’ allergy to avoid MRSA risk Malaria cases rise sharply Africans in the UK most likely to acquire malaria A fifth of unvaccinated ethnic girls say they don ’t need HPV jab NICE urges wider uptake of flu vaccination
Source: OnMedica Latest News - January 24, 2019 Category: UK Health Source Type: news

Use of Rostafuroxin to Inhibit Viral Infection
Acute respiratory infections during early childhood constitute a major human health burden. Human respiratory syncytial virus (RSV) is the most common and important viral cause of severe acute pediatric respiratory infections worldwide. Mortality due to RSV in the post-neonatal (28 days to 1 year old) population is second only to malaria. It is estimated that RSV causes 34 million lower respiratory tract infections, 4 million hospitalizations, and 66,000-199,000 deaths every year in children less than 5 years of age. Most mortality occurs in the developing world where clinical care is less accessible. Mortality is low in t...
Source: NIH OTT Licensing Opportunities - October 25, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

Understanding the Liver-Stage Biology of Malaria Parasites: Insights to Enable and Accelerate the Development of a Highly Efficacious Vaccine.
Abstract In August 2017, the National Institute of Allergy and Infectious Diseases convened a meeting, entitled "Understanding the Liver-Stage Biology of Malaria Parasites to Enable and Accelerate the Development of a Highly Efficacious Vaccine," to discuss the needs and strategies to develop a highly efficacious, whole organism-based vaccine targeting the liver stage of malaria parasites. It was concluded that attenuated sporozoite platforms have proven to be promising approaches, and that late-arresting sporozoites could potentially offer greater vaccine performance than early-arresting sporozoites against malar...
Source: The American Journal of Tropical Medicine and Hygiene - August 20, 2018 Category: Tropical Medicine Authors: Mo AX, McGugan G Tags: Am J Trop Med Hyg Source Type: research

Newly described human antibody prevents malaria in mice
(NIH/National Institute of Allergy and Infectious Diseases) Scientists have discovered a human antibody that protected mice from infection with the deadliest malaria parasite, Plasmodium falciparum. The research findings provide the basis for future testing in humans to determine if the antibody can provide short-term protection against malaria, and also may aid in vaccine design. NIAID investigators led the research with colleagues at the Fred Hutchinson Cancer Research Center. Currently, there is no highly effective, long-lasting vaccine to prevent malaria.
Source: EurekAlert! - Infectious and Emerging Diseases - March 19, 2018 Category: Infectious Diseases Source Type: news

Compositions and Methods for Blocking Transmission of Plasmodium
According to the World Health Organization, about 3.2 billion people – nearly half of the world ' s population – are at risk of infection by Plasmodium parasites, resulting in malaria. An estimated 214 million cases and 438,000 deaths were due to malaria in 2015.P47 protein expressed by Plasmodium species allow malaria parasites to evade the mosquito immune system, thereby facilitating the transmission of malaria parasites. NIAID inventors have discovered the region of P47 protein responsible for the immune evasion function of this protein. Specific sequences of protein fragments of P47 have proven to be both highly an...
Source: NIH OTT Licensing Opportunities - January 11, 2018 Category: Research Authors: ajoyprabhu3 Source Type: research

New vaccine shows early success protecting against malaria
Four of eight monkeys that were given the injection were completely protected from the deadly blood disease, researchers from the National Institute of Allergy and Infectious Diseases found.
Source: the Mail online | Health - May 24, 2017 Category: Consumer Health News Source Type: news

Modified experimental vaccine protects monkeys from deadly malaria
(NIH/National Institute of Allergy and Infectious Diseases) Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH, modified an experimental malaria vaccine and showed that it completely protected four of eight monkeys that received it against challenge with the virulent Plasmodium falciparum malaria parasite. In three of the remaining four monkeys, the vaccine delayed when parasites first appeared in the blood by more than 25 days.
Source: EurekAlert! - Infectious and Emerging Diseases - May 22, 2017 Category: Infectious Diseases Source Type: news

Waning Immunity and Microbial Vaccines - Workshop of the National Institute of Allergy and Infectious Diseases.
Abstract Since the middle of the 20th century, vaccines have made a significant public health impact controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents with complex life cycles and antigenic variation remains a key challenge. Novel strategies to characterize the short and long-term immune responses to vaccines, and to induce immune responses that mimic natural infection have recently emerged. New technologies and ...
Source: Clinical and Vaccine Immunology - May 10, 2017 Category: Allergy & Immunology Authors: Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE Tags: Clin Vaccine Immunol Source Type: research

AMA1-RON2 Complex-Based Vaccine Against Malaria
This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of thePlasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion inin vitro assays, but protection has so far not translated toin vivo human infections. NIAID investigators have demonstrated that interaction between AMA1 and RON2 (or peptide thereof) is essential for malaria parasites to successfully enter human red blood cells (RBCs). V...
Source: NIH OTT Licensing Opportunities - March 9, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research