Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses

In conclusion, our study indicated that 3 weeks antibiotic administration induced elevated expression of many cytokines in mouse colon, suggesting that there might be a direct interaction between antibiotics and host tissue. Furthermore, different antibiotics used can lead to different effects on mouse models. Broad spectrum antibiotic enrofloxacin had a stronger effect on the cytokines response in the colon. Vancomycin can induce significant changes in composition and metabolic profiling of gut microbiota. Compared to enrofloxacin and vancomycin, polymixin B sulfate had a weakest effect. The differences observed in composition and function of gut microbial communities may contribute to inter-individual variation in cytokine responses to microbial stimulations in host. Our study provides a novel insight regarding a complex network that integrates the different interactions between gut microbiota, metabolic functions, and host immunity. Ethics Statement The animal experiments were approved by and conducted in accordance with the guidelines set by the Institutional Animal Care and the animal ethics committees of Capital Medical University. Author Contributions LS and QH conceived and designed the study. LS, XZ, YZ, KZ, QX, NC, ZC, NZ, and JZ performed the experiments. LS and QH analyzed data and wrote the manuscript. All authors reviewed and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research