Waning Immunity and Microbial Vaccines - Workshop of the National Institute of Allergy and Infectious Diseases.

Waning Immunity and Microbial Vaccines - Workshop of the National Institute of Allergy and Infectious Diseases. Clin Vaccine Immunol. 2017 May 10;: Authors: Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE Abstract Since the middle of the 20th century, vaccines have made a significant public health impact controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents with complex life cycles and antigenic variation remains a key challenge. Novel strategies to characterize the short and long-term immune responses to vaccines, and to induce immune responses that mimic natural infection have recently emerged. New technologies and approaches in vaccinology such as adjuvants, delivery systems and antigen formulations have the potential to elicit more durable protection and less adverse reactions, together with in-vitro systems have the capacity to model and accelerate vaccine development. The National Institute of Allergy and Infectious Diseases (NIAID) held a workshop on September 19, 2016 that focused on waning immunity to selected vaccines (Bordetella pertussis, Salmonella typhi, Neisseria meningitidis, influenza, mumps, malaria), with an emphasis on identifying knowledge gaps, future research...
Source: Clinical and Vaccine Immunology - Category: Allergy & Immunology Authors: Tags: Clin Vaccine Immunol Source Type: research