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Total 90 results found since Jan 2013.

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Conclusions: Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. https://doi.org/10.1289/EHP318 Received: 09 April 2016 Revised: 09 October 2016 Accepted: 24 October 2016 Published: 14 June 2017 Address correspondence to R. Raqib, Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka-1212, Bangladesh. Telephone: 880-2-9827068. E-mail: rubhana@icddrb.org Supplemental Material is available online (https://doi.org/10.1289/EHP318). The authors declare they have n...
Source: EHP Research - June 15, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

The Effect of Oral Levamisole Co-administration on the Level of Immune Response to Hepatitis B Vaccine in Healthy Individuals: A Randomized Clinical Trial.
Abstract Despite its proven efficacy, the hepatitis B vaccine requires improvements in immune enhancement and durability, especially in the elderly. Levamisole, an immune modulator, has been tested as an adjuvant to hepatitis B vaccine in several studies in immune-compromised populations. However, we aimed to evaluate the effect of levamisole on the immune response to hepatitis B vaccine in healthy subjects. In this randomized clinical trial, healthy family members of chronic hepatitis B patients were given twenty-microgram intramuscular injections of hepatitis B vaccine at 0, 1, and 6 months and 50 miligrams of o...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2017 Category: Allergy & Immunology Authors: Hosseini M, Shalchiantabrizi P, Dadgarmoghaddam M, Ahmady-Simab S, Behjati A, Salari M Tags: Iran J Allergy Asthma Immunol Source Type: research

How Common is α -1-Antitrypsin Deficiency?
Discussion α-1-Antitrypsin Deficiency (A1AT) is a common single-gene mutation disease that is homozygous recessive. The normal allele is called M and the most common abnormal allele is Z. There are other alleles though. The gene codes for one of the primary protease inhibitors in the serum, thus those who are homozygous for the Z gene are sometimes referred to as “PIZZ” or “PIZ.” α-1-Antitrypsin is found in all body tissues but is especially important in the serum and lung. As noted it is one of the primary neutrophil protease inhibitors in the serum, and acts to neutralize these enzymes...
Source: PediatricEducation.org - April 24, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

New Child Vaccine Schedule Alters Tdap Timing, Cuts HPV Doses New Child Vaccine Schedule Alters Tdap Timing, Cuts HPV Doses
The updated recommendations clarify timing for Tdap vaccination of pregnant teens, warn against LAIV use, and narrow the window for hepatitis B vaccines to within 24 hours of birth.Medscape Medical News
Source: Medscape Allergy Headlines - February 6, 2017 Category: Allergy & Immunology Tags: Pediatrics News Alert Source Type: news

Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis
Conclusions This analysis confirms and expands the known safety profile of adalimumab and reports no additional safety risk of laboratory abnormalities, hepatitis B reactivation and pregnancy outcomes, including spontaneous abortions and birth defects. The benefits of influenza vaccination are reinforced. Trial registration numbers NCT00195663, NCT00195702, NCT00448383, NCT00049751, NCT00234845, NCT00650390, NCT00235859, NCT00647920, NCT00649545, NCT00647491, NCT00649922, NCT00538902, NCT00420927, NCT00870467, NCT00650156, NCT00647270, NCT01185288, NCT01185301.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Burmester, G. R., Landewe, R., Genovese, M. C., Friedman, A. W., Pfeifer, N. D., Varothai, N. A., Lacerda, A. P. Tags: Open access, Immunology (including allergy), Travel medicine, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Diabetes Patients Vary in Uptake of Flu and Other Vaccines Diabetes Patients Vary in Uptake of Flu and Other Vaccines
Although poor people are most likely to have diabetes, among those with diabetes, they are least likely to have received vaccines for influenza, pneumococcus, hepatitis B, and shingles, new data indicate.Medscape Medical News
Source: Medscape Allergy Headlines - December 13, 2016 Category: Allergy & Immunology Tags: Diabetes & Endocrinology News Source Type: news

Immunomodulation of TH2 biased immunity with mucosal administration of nanoemulsion adjuvant.
Abstract TH2-biased immune responses are associated with inadequate protection against some pathogens and with cancer, colitis, asthma and allergy. Since most currently used vaccine adjuvants induce a TH2-biased response, this has led to interest in developing adjuvants capable of activating TH1 immunity and modulating existing TH2 responses. Immunotherapies to shift immune responses from TH2 to TH1 have generally required prolonged immunization protocols and have not induced effective TH1 responses. We have demonstrated that nanoscale emulsions (NE), a novel mucosal adjuvant, induce robust IgA and IgG antibody re...
Source: Vaccine - June 13, 2016 Category: Allergy & Immunology Authors: Bielinska AU, O'Konek JJ, Janczak KW, Baker JR Tags: Vaccine Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Meet The Italian Doctor Using Facebook To Fight Anti-Vaxxers
Shocked by the growing number of children who die from vaccine-preventable diseases in Italy -- as well as stories of parents who refuse to vaccinate their kids -- a professor of microbiology and virology has decided to take on anti-vaxxers where they spread misinformation: on Facebook. For the more than 20,000 followers of his Facebook page, Dr. Roberto Burioni, a professor at the Vita-Salute San Raffaele University in Milan, Italy, explains the science behind vaccines and uses scientific data to refute rumors about their dangers. When he is not citing scientific studies, he pegs hi...
Source: Healthy Living - The Huffington Post - April 12, 2016 Category: Consumer Health News Source Type: news

Role of viruses and other microbes in the pathogenesis of type 1 diabetes.
In conclusion, these microbial effects offer attractive possibilities for the development of preventive interventions for type 1 diabetes based on the elimination of triggering agents (e.g. enterovirus vaccines) or use of protective microbes as probiotics. PMID: 24611784 [PubMed - indexed for MEDLINE]
Source: International Reviews of Immunology - February 17, 2016 Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research

Occupational hazards and preventive practices among students and faculty at a private dental institution in India.
CONCLUSIONS: Majority of the study population were aware of the biological hazards associated with the practice of dentistry. None of the preventive measures were observed by all the participants. PMID: 22617332 [PubMed - indexed for MEDLINE]
Source: Stomatologija - December 12, 2015 Category: Dentistry Tags: Stomatologija Source Type: research

Question 1: Does prophylactic paracetamol prevent fever after vaccination in infants?
Scenario A 2-month-old infant is brought into the emergency department with a 24 h history of fever. He was born at term and had an uneventful neonatal period with no risk factors for sepsis. Clinical examination was unremarkable apart from a temperature of 38.5°C. Upon further questioning, his mother revealed that the infant had received his routine vaccinations the previous day. She had been advised to give prophylactic paracetamol at the time of vaccination but had refrained from doing so because, 2 years previously, the same practice nurse had told her to give paracetamol to her older child only if he dev...
Source: Archives of Disease in Childhood - November 19, 2015 Category: Pediatrics Authors: Braccio, S., Saliba, V., Ramsay, M., Ladhani, S. N. Tags: ADC Archimedes, Liver disease, Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Drugs: infectious diseases, Hepatitis and other GI infections, Meningitis, TB and other respiratory infections, Tropical medicine (infect Source Type: research

Incident Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Men Who Have Sex With Men From Pre-HAART to HAART Periods: A Cohort Study.
Conclusion: Effective HAART is associated with lower incidence of HBV infection; however, even in the HAART era, incidence of HBV infection remains high among MSM. Primary Funding Source: National Institute of Allergy and Infectious Diseases. PMID: 26457744 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - October 13, 2015 Category: Internal Medicine Authors: Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Phair J, Witt MD, Thio CL Tags: Ann Intern Med Source Type: research

Hepatitis C Virus Subtype 3a Envelope Protein 1 Binding with Human Leukocyte Antigen Class I Types of Pakistani Population: Candidate Epitopes for Synthetic Peptide Vaccine.
Abstract The object of this cross sectional study was to determine the HCV subtype 3a envelope protein binding affinity with Human Leukocyte Antigen. Envelope 1 (E1) protein is one of the structural proteins responsible for entering the cells through the receptors. The binding affinity of E1 protein epitopes to the selected Human Leukocyte Antigen (HLA) class I alleles was investigated using the computer-based tools. These prediction tools were also used to design the synthetic vaccine's candidate epitopes and to identify the individuals/populations who are likely to be responder to those vaccines.The mean frequen...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 1, 2015 Category: Allergy & Immunology Authors: Nawaz-Tipu H Tags: Iran J Allergy Asthma Immunol Source Type: research

Sugar and warmth additively decrease pain in newborns getting vaccines
Commentary on: Gray L, Garza E, Zageris D, et al. Sucrose and warmth for analgesia in healthy newborns: an RCT. Pediatrics 2015;135:e607–14. Context Sucrose as an analgesic has been well studied in the newborn and infant population undergoing brief noxious stimuli such as vaccines or heel sticks.1 Providing additional, non-pharmacological, therapeutic options to create a synergy with the sucrose has been considered in other studies.2 Breast feeding, which supplies the sweetness of sugar (breast milk) and skin-to-skin contact, has been thought to provide radiant body heat.3 4 The authors of this study draw on their pr...
Source: Evidence-Based Medicine - July 24, 2015 Category: Internal Medicine Authors: Harrington, J. W. Tags: Liver disease, Clinical trials (epidemiology), Immunology (including allergy), Hepatitis and other GI infections, Vaccination / immunisation, Pain (neurology), Childhood nutrition, Pain (palliative care), Drugs: musculoskeletal and joint diseases, Hepatit Source Type: research