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Vaccination: Hepatitis Vaccine
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Studies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates < em > Blomia tropicalis < /em > Airway Inflammation
CONCLUSION: HBcAg-rBlo t 5-21, a protein vaccine containing both the hepatitis B core antigen and the Blomia tropicalis fusion allergen rBlo t 5-21, could be a suitable vaccination for preventing allergy disorders caused by Blomia tropicalis.PMID:36424919 | PMC:PMC9680538 | DOI:10.2147/JIR.S380526
Source: Cell Research - November 25, 2022 Category: Cytology Authors: Yechun Pei Zhengpan Xiao Shuangshuang Wei Meiqi Peng Chenghui Luo Dayong Wang Source Type: research
Designing Next-Generation Vaccines Against Common Pan-Allergens Using < em > In Silico < /em > Approaches
In this study, the vaccine design is based on hapten-carrier concept in which the carrier protein is an immunogenic component providing T cell help. Either PreS protein of hepatitis B or cholera enterotoxin B (CTB) fused with three tetanus toxoid fragments (TTFrC) was used here as the carrier. The hapten components are nonanaphylactic peptides (NAPs) derived from experimentally determined antigenic regions of the allergens. The charged residues of NAPs are selectively modified to obliterate IgE, as well as T cell reaction, and hence, are safe to apply in allergy patients. Various combinations of vaccine constructs (PreS/CT...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - July 19, 2022 Category: Microbiology Authors: Gaurab Sircar Nandini Ghosh Sudipto Saha Source Type: research
True, true, and unrelated: Stop routine testing to vaccine excipients for suspected vaccine allergy
Vaccines for infectious diseases contain multiple minor ingredients called excipients, such as egg ovalbumin, polysorbate (PS), polyethylene glycol (PEG), neomycin, thimerosal, and other contaminants (eg, lactose, yeast, formaldehyde, gelatin, latex).1,2 Allergic reactions occurring to vaccines are rare, but focus on vaccine excipients as the provoking cause.3 Examples of this include egg ovalbumin in yellow fever (YF), gelatin in measles, mumps, and rubella (MMR) and several other vaccines, yeast in hepatitis B vaccines, and casein with diphtheria tetanus acellular pertussis (DTaP).
Source: Annals of Allergy, Asthma and Immunology - June 16, 2022 Category: Allergy & Immunology Authors: Matthew Greenhawt Tags: Perspective Source Type: research
ACIP Issues Adult Vaccination Schedule 2022 ACIP Issues Adult Vaccination Schedule 2022
Changes affect zoster, pneumococcal, and hepatitis B vaccines, and COVID-19 is now included.News Alerts
Source: Medscape Allergy Headlines - February 17, 2022 Category: Allergy & Immunology Tags: Internal Medicine News Alert Source Type: news
New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
