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Total 146 results found since Jan 2013.

Life-saving transplant results in end to peanut allergy
Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's (ACAAI) Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant. "It has been reported that bone marrow and liver transplants can transfer peanut allergy from donor to recipient," said allergist Yong Luo, MD, Ph.D., ACAAI member and lead study author...
Source: Health News from Medical News Today - November 12, 2013 Category: Consumer Health News Tags: Allergy Source Type: news

A lurking threat: transfer of peanut allergy through peripheral blood stem cell transplantation
Conclusions Because of the close temporal association between the onset of allergic symptoms in the PBSC recipient it is reasonable to assume that the acquired peanut allergy had been transferred from the donor to the recipient by the PBSC graft.
Source: World Allergy Organization Journal - February 8, 2016 Category: Allergy & Immunology Source Type: research

Severe immunodeficiency associated with acute lymphoblastic leukemia and its treatment.
PMID: 29563054 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 19, 2018 Category: Allergy & Immunology Authors: Raje N, Snyder BL, Hill DA, Streicher JL, Sullivan KE Tags: Ann Allergy Asthma Immunol Source Type: research

Expression of TNF- and HNRNPL-related Immunoregulatory Long Non-coding RNA (THRIL) in Acute Myeloid Leukemia: Is There Any Correlation?
In conclusion, our study showed that THRIL cannot be used as an informative biomarker for AML diagnosis, however, our results need to be clarify by evolution of more cases. PMID: 29908545 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Sayad A, Hajifathali A, Omrani MD, Arsang-Jang S, Hamidieh AA, Taheri M Tags: Iran J Allergy Asthma Immunol Source Type: research

Scrutinizing the Expression and Blockade of Inhibitory Molecules Expressed on T Cells from Acute Myeloid Leukemia Patients.
In conclusion, our data indicate that CD4+ and CD8+ T cells from AML patients appeared to be exhausted and blockade of some immune checkpoints can improve the proliferation of those cells. PMID: 29908544 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2018 Category: Allergy & Immunology Authors: Abdolmaleki M, Mojtabavi N, Zavvar M, Vaezi M, Noorbakhsh F, Nicknam MH Tags: Iran J Allergy Asthma Immunol Source Type: research

Cytotoxicity Assessment and Apoptosis-related Gene Profiling of Antibody Treated Acute Myeloid Leukemia (AML) and Acute Lymphocytic Leukemia (ALL) Cancerous Cell Lines.
Abstract Acute myeloid leukemia (AML) and acute lymphocytic leukemia (ALL) are common acute leukemia in adults and children, respectively. In these malignancies, chemotherapy is the main treatment strategy that fails in many cases and is usually associated with adverse effects on healthy cells. In this regard, the development of new therapies is essential. Monoclonal antibodies directed to the cell surface markers of leukemic blasts may have promising consequences with minimal toxic effects on normal cells. Since cluster of differentiation 45Ra (CD45Ra) and CD123 antigens, two considered surface markers of leukemi...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 29, 2019 Category: Allergy & Immunology Authors: Habibi-Anbouhi M, Kafi Z, Ghazizadeh L, Kharazi S, Behdani M, Faraji F, Shokrgozar MA Tags: Iran J Allergy Asthma Immunol Source Type: research

Oridonin Could Inhibit Inflammation and T-cell Immunoglobulin and Mucin-3/Galectin-9 (TIM-3/Gal-9) Autocrine Loop in the Acute Myeloid Leukemia Cell Line (U937) as Compared to Doxorubicin.
In this study, we evaluated the effects of oridonin and doxorubicin on the TIM-3/Gal-9 autocrine loop. We also evaluated oridonin anti-inflammatory and anti-cancer properties on U937 cells, as an AML cell line in comparison to doxorubicin as a common anthracycline drug for AML treatment. Cell counting kit-8 (CCK-8) was applied to evaluate the cytotoxicity of oridonin and doxorubicin on U937 cells and also to determine the impact of galectin-9 (Gal-9) on their proliferation. The effects of oridonin and doxorubicin on Gal-9, TIM-3, and interleukin-1β (IL-1β) gene expression were determined by real-time polymerase chain rea...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 19, 2020 Category: Allergy & Immunology Authors: Nasri F, Sadeghi F, Behranvand N, Samei A, Bolouri MR, Azari T, Abdollahi E, Ghazizadeh F, Motevalian M, Hassan ZM, Falak R Tags: Iran J Allergy Asthma Immunol Source Type: research

PEG‐asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol
ConclusionClinical allergy to PEG‐asparaginase occurred early in treatment, was in general moderate in severity, and mostly developed within 2 hr after PEG‐asparaginase administration. The risk of subsequent Erwinase allergic reactions was low. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc.
Source: Pediatric Blood and Cancer - November 21, 2014 Category: Cancer & Oncology Authors: Louise Tram Henriksen, Arja Harila‐Saari, Ellen Ruud, Jonas Abrahamsson, Kaie Pruunsild, Goda Vaitkeviciene, Ólafur Gísli Jónsson, Kjeld Schmiegelow, Mats Heyman, Henrik Schrøder, Birgitte Klug Albertsen, Tags: Research Article Source Type: research

Cancers, Vol. 15, Pages 1829: Associations of T-Cell Receptor Repertoire Diversity with L-Asparaginase Allergy in Childhood Acute Lymphoblastic Leukemia
Yang Allen E. J. Yeoh Asparaginase is a critical component of therapy for childhood acute lymphoblastic leukemia (ALL), but it is commonly associated with allergy, which results in morbidity and poorer outcomes. The underlying basis of this allergy is undoubtedly immune-mediated, but the exact components of T-cell immunity have yet to be characterized. We performed longitudinal TCR sequencing of 180 bone marrow samples from 67 children with B-ALL treated as part of the Ma-Spore-ALL-2010 trial, and we evaluated the associations of TCR profile with asparaginase hypersensitivity, with functional validation of asparagina...
Source: Cancers - March 17, 2023 Category: Cancer & Oncology Authors: Shawn H. R. Lee Zhenhua Li Evelyn H. Z. Lim Winnie H. N. Chin Nan Jiang Kean Hui Chiew Zhiwei Chen Bernice L. Z. Oh Ah Moy Tan Hany Ariffin Jun J. Yang Allen E. J. Yeoh Tags: Article Source Type: research

The great disappearing act: Bone marrow receiver cured of allergy
(American College of Allergy, Asthma, and Immunology) Not only can bone marrow transplants be life-saving for children with acute lymphocytic leukemia, they may also cure peanut allergies. According to research presented during the American College of Allergy, Asthma and Immunology's Annual Scientific Meeting, a 10-year-old boy no longer had a peanut allergy after undergoing a bone marrow transplant.
Source: EurekAlert! - Medicine and Health - November 8, 2013 Category: Global & Universal Source Type: news

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies.
Abstract Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of a...
Source: Clinical Colorectal Cancer - June 7, 2016 Category: Cancer & Oncology Authors: Cui Y, Hill AW Tags: Clin Rev Allergy Immunol Source Type: research

Erwinia asparaginase achieves therapeutic activity after pegaspargase allergy: a report from the Children's Oncology Group
AALL07P2 evaluated whether substitution of Erwinia asparaginase 25 000 IU/m2 for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) ≥0.10 IU/mL. AALL07P2 enrolled 55 eligible/evaluable patients. NSAA ≥0.1 IU/mL was achieved in 38 of 41 patients (92.7%) with acceptable samples 48 hours and in 38 of 43 patients (88.4%) 72 hours after dosing during course 1. Among samples obtained during all courses, 95.8% (252 of 263) of 48-hour samples and 84.5%...
Source: Blood - July 25, 2013 Category: Hematology Authors: Salzer, W. L., Asselin, B., Supko, J. G., Devidas, M., Kaiser, N. A., Plourde, P., Winick, N. J., Reaman, G. H., Raetz, E., Carroll, W. L., Hunger, S. P. Tags: Pediatric Hematology, Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies
Abstract Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of a...
Source: Clinical Reviews in Allergy and Immunology - June 7, 2016 Category: Allergy & Immunology Source Type: research

Evaluation of Morbidity and Mortality from Drug Allergies in Patient with Acute Myeloid Leukemia
Patients with a drug allergy are known to have increased morbidity and mortality. Patients with Acute Myeloid Leukemia (AML) are known to have recurrent severe infections due to immunosuppression from chemotherapy. The prevalence of drug allergy in patients with AML and its effect on morbidity and mortality has not been previously studied.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Maria Paula Henao, Faoud Terrence Ishmael Source Type: research

Progress in Pediatrics in 2012: choices in allergy, endocrinology, gastroenterology, hematology, infectious diseases, neurology, nutrition and respiratory tract illnesses
In this review, we summarize the progresses in allergy, endocrinology, gastroenterology, hematology, infectious diseases, neurology, nutrition and respiratory tract illnesses that have been published in The Italian Journal of Pediatrics in 2012. The induction of Treg activity by probiotics might be effective for promoting tolerance towards food allergens. Nasal cytology is useful in patients with rhinitis for diagnosing chronic non-allergic non-infectious diseases. Atopic eczema is associated both with an aberrant skin matrix and impaired systemic immune response. Therefore, isolated topical treatment may have suboptimal e...
Source: Italian Journal of Pediatrics - May 8, 2013 Category: Pediatrics Authors: Carlo CaffarelliFrancesca SantamariaAlessandra VotteroSergio Bernasconi Source Type: research