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Total 1917 results found since Jan 2013.
Successful NCBI-NIAID Codeathon Explored VCF Files in Population Genomics
Variant Call Format (VCF) files provide a crucial way to record and share information about genetic variants across samples. NCBI joined forces with the National Institute of Allergy and Infectious Diseases (NIAID) to co-host the VCF Files for Population Genomics Codeathon (July 31 – August 4). The codeathon focused on innovative methods for harnessing VCF … Continue reading Successful NCBI-NIAID Codeathon Explored VCF Files in Population Genomics →
Source: NCBI Insights - September 21, 2023 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Codeathon Genomics SARS-CoV-2 Source Type: news
The SARS-CoV-2 Pandemic and Asthma: What We Have Learned and What is still Unknown
The SARS-CoV-2 pandemic has brought new insights into the immunological intricacies of asthma. In this review, we discuss the epidemiology of asthma in patients infected with SARS-CoV-2 and the risk of severe infection. Type 2 inflammation had an overall protective effect against SARS-CoV-2 infection by various mechanisms summarized in this review. Asthma, intranasal, and inhaled corticosteroids decreased the ACE2 receptor, an important receptor for SARS-CoV-2 entry into host cells. We summarize the nuances of treatment of type 2 inflammation despite its underlying protective effects.
Source: Journal of Allergy and Clinical Immunology - September 20, 2023 Category: Allergy & Immunology Authors: Christa McPhee, Kateryna Yevdokimova, Linda Rogers, Monica Kraft Source Type: research
Chronic Spontaneous Urticaria Following mRNA COVID-19 Booster Vaccination at a Military Academy
We present a retrospective case series of CSU following Moderna COVID-19 booster vaccinations at the US Naval Academy (USNA). Demographics, clinical features, and impact on readiness were evaluated. Forty-nine students from the USNA were evaluated for urticaria after their third COVID-19 booster vaccination. Seventeen individuals were diagnosed with CSU. The median age was 20 years and predominantly male; the median time interval between vaccination and the onset of urticaria was 11 days. Out of 13 referred to Allergy, 7 patients had CU index performed and 2 were positive. Four patients received a second booster vaccinatio...
Source: Military Medicine - September 19, 2023 Category: International Medicine & Public Health Authors: Mechelle A Miller Emily R Raffetto Rachel U Lee Source Type: research
Pre-Existing Allergies Patients with Higher Viral Load and Longer Recovery Days Infected by SARS-CoV-2 Omicron BA.2 in Shanghai, China, 2022
Source: Journal of Asthma and Allergy - September 1, 2023 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
Immune response after SARS-CoV-2 vaccination in patients with inflammatory immune-mediated diseases receiving immunosuppressive treatment
Real world data on the response to the SARS-CoV-2 vaccine in patients with immunomediated diseases (IMIDs) treated with immunesuppressants is of great interest because vaccine response may be impaired. The mai...
Source: Allergy, Asthma and Clinical Immunology - August 19, 2023 Category: Allergy & Immunology Authors: Chamaida Plasencia-Rodr íguez, Ana Martínez-Feito, Marta Hernández, Lucia Del Pino-Molina, Marta Novella-Navarro, Yolanda Serrano, Miguel González-Muñoz, Diana Peiteado, Gema Bonilla, Irene Monjo, Laura Nuño, Carolina Tornero, Eduardo López-Granado Tags: Research Source Type: research
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research
Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance.
Obesity and type 2 diabetes impair SARS-CoV-2 mRNA vaccine efficacy in a murine model.
Source: Journal of Allergy and Clinical Immunology - August 16, 2023 Category: Allergy & Immunology Authors: Timothy R. O ’Meara, Etsuro Nanishi, Marisa E. McGrath, Soumik Barman, Danica Dong, Carly Dillen, Manisha Menon, Hyuk-Soo Seo, Sirano Dhe-Paganon, Robert K. Ernst, Ofer Levy, Matthew B. Frieman, David J. Dowling Source Type: research
Post Omicron, Most Canadians Have Hybrid Immunity Post Omicron, Most Canadians Have Hybrid Immunity
Most Canadians now have hybrid immunity against SARS-CoV-2 through a combination of infection and vaccination, but certain groups remain vulnerable.Medscape Medical News
Source: Medscape Allergy Headlines - August 14, 2023 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT
ConclusionsMost IBD patients showed a sufficient immune response to COVID-19 vaccination regardless of clinical factors. Assessment of changes over time is essential to optimize COVID-19 vaccination, especially in persistently low responders.Graphical abstract
Source: Journal of Gastroenterology - August 10, 2023 Category: Gastroenterology Source Type: research
Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review
Inborn errors of immunity (IEIs) are considered significant challenges for children with IEIs, their families, and their medical providers. Infections are the most common complication of IEIs and children can ...
Source: Allergy, Asthma and Clinical Immunology - August 9, 2023 Category: Allergy & Immunology Authors: Saad Alhumaid, Koblan M. Al Mutared, Zainab Al Alawi, Zainah Sabr, Ola Alkhars, Muneera Alabdulqader, Nourah Al Dossary, Fatemah M. ALShakhs, Rabab Abbas Majzoub, Yousef Hassan Alalawi, Khalid Al Noaim, Abdulrahman A. Alnaim, Mohammed A. Al Ghamdi, Abdula Tags: Research Source Type: research
Asthma in elderly and COVID-19: results of 90-day post-hospital follow-up
Once the first wave of SARS-CoV-2 novel coronavirus disease subsided, the attempt was made to investigate both short- and long-term potential consequences, especially in high-risk patient cohorts including those after prolonged hospitalization and intensive therapy1. Symptoms persisting 3 - 6 months after acute COVID-19 (post-COVID syndrome) have been described 2,3,4,5. Currently, there is a lack of information on post-COVID consequences in elderly patients with asthma. Asthma in elderly is known to have specific features, such as high comorbidity, use of multiple pharmacological agents, individual response to treatment, d...
Source: Annals of Allergy, Asthma and Immunology - August 7, 2023 Category: Allergy & Immunology Authors: Sergey N. Avdeev, Viliya V. Gaynitdinova, Anna A. Pozdnakova, Svetlana Yu Chikina, Karina A. Kosobokova Tags: Letters Source Type: research
