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Total 1917 results found since Jan 2013.
Companies won ’t share COVID-19 shots, stalling future vaccine research
The U.S. government has tens of millions of unused doses of messenger RNA (mRNA) COVID-19 vaccines, regularly trashing shots as they pass their expiration dates. It’s a dismal reflection on recent vaccine uptake, but it’s also a serious roadblock for scientists testing and developing vaccines that could protect against future variants of SARS-CoV-2—and the next pandemic. Developers need existing vaccines as a benchmark to compare with new candidates. But government contracts with the vaccinemakers, and the companies’ own policies, prohibit the use of the vaccines for research purposes.
“At this stage of the ...
Source: ScienceNOW - May 30, 2023 Category: Science Source Type: news
Characteristics of immune response profile in patients with immediate allergic and autoimmune urticarial reactions induced by SARS-CoV-2 vaccines
In conclusion, our results revealed that multiple vaccine components, inflammatory cytokines, and autoreactive IgG/IgE antibodies contribute to SARS-COV-2 vaccine-induced immediate allergic and autoimmune urticarial reactions.PMID:37245259 | PMC:PMC10183637 | DOI:10.1016/j.jaut.2023.103054
Source: Journal of Autoimmunity - May 28, 2023 Category: Allergy & Immunology Authors: Chuang-Wei Wang Chun-Bing Chen Chun-Wei Lu Wei-Ti Chen Rosaline Chung-Yee Hui Tsu-Man Chiu Min-Hui Chi Jing-Chi Lin Yu-Huei Huang Ya-Ching Chang Jennifer Wu Kuan-Yu Chen Yang Yu-Wei Lin Tzong-Yun Ger Jing Yi Lin Wan-Ting Tsai Yen-Ju Pan Wen-Hung Chung Source Type: research
B cells: The many facets of B cells in allergic diseases
B cells play a key role in our immune system through their ability to produce antibodies, suppress a pro-inflammatory state, and contribute to central immune tolerance. We aim to provide an in-depth knowledge of the molecular biology of B cells, including their origin, developmental process, types and subsets, and functions. In allergic diseases, B cells are well-known to induce and maintain immune tolerance through the production of suppressor cytokines such as interleukin-10 (IL-10). Similarly, B cells protect against viral infections such as SARS-CoV-2 that caused the recent COVID-19 pandemic.
Source: Journal of Allergy and Clinical Immunology - May 26, 2023 Category: Allergy & Immunology Authors: Pattraporn Satitsuksanoa, Sayuri Iwasaki, Jolien Boersma, Manal Bel imam, Stephan R. Schneider, Iris Chang, Willem van de Veen, M übeccel Akdis Source Type: research
The COVID-19 virus mutated to outsmart key antibody treatments. Better ones are coming
In 2020, as the COVID-19 pandemic raged and other effective drugs were elusive, monoclonal antibodies (mAbs) emerged as a lifesaving treatment. But now, 3 years later, all the approvals for COVID-19–fighting antibodies have been rescinded in the United States, as mutations of the SARS-CoV-2 virus have left the drugs—which target parts of the original virus—ineffective.
Researchers around the globe are now trying to revive antibody treatments by redesigning them to take aim at targets that are less prone to mutation. “There are new approaches that present a much more challenging task for the virus to evade,” ...
Source: ScienceNOW - May 24, 2023 Category: Science Source Type: news
COVID-19 Incidence and Disease Course Among Patients at an Allergy Department
CONCLUSION: The cumulative COVID-19 incidence in patients from the allergy cohort was higher compared with the general Dutch population, but similar compared with household members. There was no difference in symptoms, disease duration, or hospitalization rate between the allergy cohort and their household members.PMID:37207194 | PMC:PMC10189845 | DOI:10.1177/27534030231172391
Source: Adv Data - May 19, 2023 Category: Epidemiology Authors: Louise E van der Aa Inge S van Egmond Martijn van der Sluijs A A Sophie den Otter Nadie H M Bosmans Sabine E van Beek Angela Hartman Niels A D Guchelaar Paul L A van Daele Maurits S van Maaren P Martin van Hagen Maud A W Hermans Saskia M Rombach Source Type: research
