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Total 1917 results found since Jan 2013.
New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):110-118. doi: 10.18502/ijaai.v22i1.12013.ABSTRACTCD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Zahra Golchehre Samin Sharafian Nader Momtazmanesh Zahra Chavoshzadeh Abdollah Karimi Hassan Abolhassani Maryam Kazemi Aghdam Koroush Vahidshahi Seyedehatefeh Hashemimoghaddam Farid Kosari Zahra Khafafpour Bibi Shahin Shamsian Mohammad Keramatipour Source Type: research
Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study
This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study. Eight healthy control subjects were also enrolled. The frequency of PD-1+ and CTLA-4+ lymphocytes in whole blood was evaluated by flow cytometry. Patients on DR therapy had shorter...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Esmaeil Mortaz Hamidreza Jamaati Neda K Dezfuli Hakime Sheikhzade Seyed MohammadReza Hashemian Neda Dalil Roofchayee Frazaneh Dastan Payam Tabarsi Gert Folkerts Johan Garssen Sharon Mumby Ian M Adcock Source Type: research
Correlation of Expression of MMP-2, ACE2, and TMPRSS2 Genes with Lymphopenia for Mild and Severity of COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):91-98. doi: 10.18502/ijaai.v22i1.12011.ABSTRACTSome risk causes may be associated with the severity of COVID-19. The central host-pathogen factors might affect infection are human receptor angiotensin-converting enzyme 2 (ACE2), trans-membrane protease serine 2 (TMPRSS2), and SARS-CoV-2 surface spike (S)-protein. The main purpose of this study was to determine the differences in the expression the metalloproteinases-2 (MMP-2), MMP-9, ACE2, and TMPRSS2 genes and their correlation with lymphopenia in the mild and severe types of the COVID-19 patients. Eighty-eight patients, ag...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Behrooz Ghezelbash Mehdi Rostami Mohammad Heidarvand Alireza Mafi Hamid Chegni Nahid Eskandari Source Type: research
Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study
This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study. Eight healthy control subjects were also enrolled. The frequency of PD-1+ and CTLA-4+ lymphocytes in whole blood was evaluated by flow cytometry. Patients on DR therapy had shorter...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Esmaeil Mortaz Hamidreza Jamaati Neda K Dezfuli Hakime Sheikhzade Seyed MohammadReza Hashemian Neda Dalil Roofchayee Frazaneh Dastan Payam Tabarsi Gert Folkerts Johan Garssen Sharon Mumby Ian M Adcock Source Type: research
Correlation of Expression of MMP-2, ACE2, and TMPRSS2 Genes with Lymphopenia for Mild and Severity of COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):91-98. doi: 10.18502/ijaai.v22i1.12011.ABSTRACTSome risk causes may be associated with the severity of COVID-19. The central host-pathogen factors might affect infection are human receptor angiotensin-converting enzyme 2 (ACE2), trans-membrane protease serine 2 (TMPRSS2), and SARS-CoV-2 surface spike (S)-protein. The main purpose of this study was to determine the differences in the expression the metalloproteinases-2 (MMP-2), MMP-9, ACE2, and TMPRSS2 genes and their correlation with lymphopenia in the mild and severe types of the COVID-19 patients. Eighty-eight patients, ag...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Behrooz Ghezelbash Mehdi Rostami Mohammad Heidarvand Alireza Mafi Hamid Chegni Nahid Eskandari Source Type: research
Investigating the Relationship between the Levels of IL18, RANKL Gene Expression, MicroRNA-146a and Inflammatory Factors with the Severity of COVID-19
This study evaluated miR-146a-5p expression levels in the serum of patients with COVID-19 and their association with the expression of interleukin (IL)-18 and receptor activator of nuclear factor kappa-Β ligand (RANKL) genes, and lung damage. patients with COVID-19 were divided into two groups: mild and severe phases. The severe phase is defined as having a positive polymerase chain reaction (PCR) for SARS-CoV2, and acute pulmonary symptoms. The subjects' demographic, clinical, and paraclinical characteristics were collected according to a pre-prepared checklist. Total RNA was isolated from all samples using the Trizol ki...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Karmand Hamad Khdhir Shahriar Alipour Shiva Gholizadeh-Ghaleh Aziz Seyed Hesamaddin Banihashemi Source Type: research
New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):110-118. doi: 10.18502/ijaai.v22i1.12013.ABSTRACTCD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Zahra Golchehre Samin Sharafian Nader Momtazmanesh Zahra Chavoshzadeh Abdollah Karimi Hassan Abolhassani Maryam Kazemi Aghdam Koroush Vahidshahi Seyedehatefeh Hashemimoghaddam Farid Kosari Zahra Khafafpour Bibi Shahin Shamsian Mohammad Keramatipour Source Type: research
Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study
This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study. Eight healthy control subjects were also enrolled. The frequency of PD-1+ and CTLA-4+ lymphocytes in whole blood was evaluated by flow cytometry. Patients on DR therapy had shorter...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Esmaeil Mortaz Hamidreza Jamaati Neda K Dezfuli Hakime Sheikhzade Seyed MohammadReza Hashemian Neda Dalil Roofchayee Frazaneh Dastan Payam Tabarsi Gert Folkerts Johan Garssen Sharon Mumby Ian M Adcock Source Type: research
Correlation of Expression of MMP-2, ACE2, and TMPRSS2 Genes with Lymphopenia for Mild and Severity of COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):91-98. doi: 10.18502/ijaai.v22i1.12011.ABSTRACTSome risk causes may be associated with the severity of COVID-19. The central host-pathogen factors might affect infection are human receptor angiotensin-converting enzyme 2 (ACE2), trans-membrane protease serine 2 (TMPRSS2), and SARS-CoV-2 surface spike (S)-protein. The main purpose of this study was to determine the differences in the expression the metalloproteinases-2 (MMP-2), MMP-9, ACE2, and TMPRSS2 genes and their correlation with lymphopenia in the mild and severe types of the COVID-19 patients. Eighty-eight patients, ag...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Behrooz Ghezelbash Mehdi Rostami Mohammad Heidarvand Alireza Mafi Hamid Chegni Nahid Eskandari Source Type: research
Investigating the Relationship between the Levels of IL18, RANKL Gene Expression, MicroRNA-146a and Inflammatory Factors with the Severity of COVID-19
This study evaluated miR-146a-5p expression levels in the serum of patients with COVID-19 and their association with the expression of interleukin (IL)-18 and receptor activator of nuclear factor kappa-Β ligand (RANKL) genes, and lung damage. patients with COVID-19 were divided into two groups: mild and severe phases. The severe phase is defined as having a positive polymerase chain reaction (PCR) for SARS-CoV2, and acute pulmonary symptoms. The subjects' demographic, clinical, and paraclinical characteristics were collected according to a pre-prepared checklist. Total RNA was isolated from all samples using the Trizol ki...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Karmand Hamad Khdhir Shahriar Alipour Shiva Gholizadeh-Ghaleh Aziz Seyed Hesamaddin Banihashemi Source Type: research
Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study
This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study. Eight healthy control subjects were also enrolled. The frequency of PD-1+ and CTLA-4+ lymphocytes in whole blood was evaluated by flow cytometry. Patients on DR therapy had shorter...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Esmaeil Mortaz Hamidreza Jamaati Neda K Dezfuli Hakime Sheikhzade Seyed MohammadReza Hashemian Neda Dalil Roofchayee Frazaneh Dastan Payam Tabarsi Gert Folkerts Johan Garssen Sharon Mumby Ian M Adcock Source Type: research
Correlation of Expression of MMP-2, ACE2, and TMPRSS2 Genes with Lymphopenia for Mild and Severity of COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):91-98. doi: 10.18502/ijaai.v22i1.12011.ABSTRACTSome risk causes may be associated with the severity of COVID-19. The central host-pathogen factors might affect infection are human receptor angiotensin-converting enzyme 2 (ACE2), trans-membrane protease serine 2 (TMPRSS2), and SARS-CoV-2 surface spike (S)-protein. The main purpose of this study was to determine the differences in the expression the metalloproteinases-2 (MMP-2), MMP-9, ACE2, and TMPRSS2 genes and their correlation with lymphopenia in the mild and severe types of the COVID-19 patients. Eighty-eight patients, ag...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Behrooz Ghezelbash Mehdi Rostami Mohammad Heidarvand Alireza Mafi Hamid Chegni Nahid Eskandari Source Type: research
Investigating the Relationship between the Levels of IL18, RANKL Gene Expression, MicroRNA-146a and Inflammatory Factors with the Severity of COVID-19
This study evaluated miR-146a-5p expression levels in the serum of patients with COVID-19 and their association with the expression of interleukin (IL)-18 and receptor activator of nuclear factor kappa-Β ligand (RANKL) genes, and lung damage. patients with COVID-19 were divided into two groups: mild and severe phases. The severe phase is defined as having a positive polymerase chain reaction (PCR) for SARS-CoV2, and acute pulmonary symptoms. The subjects' demographic, clinical, and paraclinical characteristics were collected according to a pre-prepared checklist. Total RNA was isolated from all samples using the Trizol ki...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Karmand Hamad Khdhir Shahriar Alipour Shiva Gholizadeh-Ghaleh Aziz Seyed Hesamaddin Banihashemi Source Type: research
New Presentation of CD27 Deficiency; Coronary Ectasia and COVID-19
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):110-118. doi: 10.18502/ijaai.v22i1.12013.ABSTRACTCD27 is a costimulatory receptor involved in the maturation of the innate and adaptive immunity. CD27, through interaction with CD70, plays a role in the control of Epstein-Barr virus (EBV) infection. CD27 deficiency leads to an immune dysregulation disease characterized by EBV susceptibility. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might put patients with primary immunodeficiency at risk for adverse outcomes. Chromogenic in situ hybridization (CISH) study was performed to detect EBV in the lymphoma tissue...
Source: Iranian Journal of Allergy, Asthma and Immunology - April 1, 2023 Category: Allergy & Immunology Authors: Zahra Golchehre Samin Sharafian Nader Momtazmanesh Zahra Chavoshzadeh Abdollah Karimi Hassan Abolhassani Maryam Kazemi Aghdam Koroush Vahidshahi Seyedehatefeh Hashemimoghaddam Farid Kosari Zahra Khafafpour Bibi Shahin Shamsian Mohammad Keramatipour Source Type: research
