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Drug: Aspirin

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Total 985 results found since Jan 2013.

Mediator production and severity of aspirin-induced respiratory reactions: Impact of sampling site and body mass index
Nasal and systemic aspirin-induced mast cell products are discordant in aspirin-exacerbated respiratory disease. Increased body mass index decreases systemic mast cell mediator production and reaction severity, supporting that metabolic pathways may uniquely regulate systemic reactions.
Source: Journal of Allergy and Clinical Immunology - January 10, 2022 Category: Allergy & Immunology Authors: Katherine N. Cahill, Pingsheng Wu, Ginger L. Milne, Taneem Amin, Joseph Singer, Katherine Murphy, Erin Lewis, Deborah Gapko, Joshua A. Boyce, Tanya M. Laidlaw Source Type: research

Comparison of aspirin desensitization outcomes between men and women with AERD
Source: International Forum of Allergy and Rhinology - January 5, 2022 Category: Allergy & Immunology Authors: Siddhant H. Tripathi, Ankur Kumar, Michael A. Kohanski, David W. Kennedy, James N. Palmer, Nithin D. Adappa, John V. Bosso Tags: RESEARCH NOTE Source Type: research

New concepts for the pathogenesis and management of aspirin-exacerbated respiratory disease
Purpose of review The purpose of this review is to provide a comprehensive summary of the current understanding of the pathogenesis of aspirin-exacerbated respiratory disease (AERD), and an update on its management. Recent findings Elevated levels of 15-oxo-eicosatetraenoic acid (15-Oxo-ETE), a newly described metabolite of arachidonic acid, have been identified in nasal polyps of AERD patients. In nasal polyps, activated basophils, and interleukin-5 -receptor-α-positive IL-5Rα+ plasma cells are associated with more severe nasal polyposis in AERD. Alveolar monocyte-derived macrophages and their persistent proi...
Source: Current Opinion in Allergy and Clinical Immunology - December 30, 2021 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Updates on treatment options in aspirin exacerbated respiratory disease
Purpose of review The aim is to describe why this review is timely and relevant. Acetylsalicylic acid exacerbated respiratory disease (AERD) is a clinically significant disease affecting approximately 7% of all asthmatics or around 1,400,000 persons in the United States alone. A large portion of these patients remain undiagnosed. This review summarizes up to date knowledge on the pathophysiology, treatment opinions and provides an expert opinion on how to approach the AERD patient. Recent findings Findings describe the main themes in the literature covered by the article. Review of the current knowledge in terms...
Source: Current Opinion in Allergy and Clinical Immunology - December 30, 2021 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Comparison of Aspirin Desensitization Outcomes Between Males and Females with AERD
Source: International Forum of Allergy and Rhinology - December 6, 2021 Category: Allergy & Immunology Authors: Siddhant H. Tripathi, Ankur Kumar, Michael Kohanski, David Kennedy, James Palmer, Nithin D. Adappa, John V. Bosso Tags: RESEARCH NOTE Source Type: research

Dupilumab as an adjunct to surgery in patients with aspirin-exacerbated respiratory disease: a case series
Ann Allergy Asthma Immunol. 2021 Dec 1:S1081-1206(21)01287-4. doi: 10.1016/j.anai.2021.11.020. Online ahead of print.NO ABSTRACTPMID:34863953 | DOI:10.1016/j.anai.2021.11.020
Source: Annals of Allergy, Asthma and Immunology - December 5, 2021 Category: Allergy & Immunology Authors: Pooja Patel Jillian C Bensko Neil Bhattacharyya Tanya M Laidlaw Kathleen M Buchheit Source Type: research

Aspirin Exacerbated Respiratory Disease and Nasal Polyp Phenotyping
Aspirin exacerbated respiratory disease (AERD) is known by the triad of chronic rhinosinusitis with nasal polyposis (CRSwNP), aspirin hypersensitivity, and asthma, but its etiology and physiopathogenesis are still unclear. This cross-sectional study was designed to investigate allergy and inflammatory cells (neutrophils vs. eosinophils) dominancy in nasal polyp tissue of patients with AERD compared to non-AERD patients. CRSwNP patients scheduled for endoscopic sinus surgery were recruited in this study. Nasal polyp tissue was analyzed for infiltrating cells, and Eosinophil dominant and neutrophil dominant polyps were deter...
Source: Iranian Journal of Pharmaceutical Research - December 4, 2021 Category: Drugs & Pharmacology Source Type: research

Dupilumab as an adjunct to surgery in patients with aspirin-exacerbated respiratory disease
Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and respiratory reactions to cyclooxygenase-1 inhibitors.1 Patients with AERD have severe CRSwNP that is often refractory to standard therapies, including intranasal corticosteroids,2 and is associated with high utilization of health care resources.3 After endoscopic sinus surgery (ESS), nasal polyp regrowth occurs within 2 years for 85% of patients with AERD,4 and for many patients, surgery does not provide complete resolution of symptoms.
Source: Annals of Allergy, Asthma and Immunology - December 1, 2021 Category: Allergy & Immunology Authors: Pooja Patel, Jillian C. Bensko, Neil Bhattacharyya, Tanya M. Laidlaw, Kathleen M. Buchheit Tags: Letters Source Type: research

Dupilumab as an adjunct to surgery in patients with aspirin-exacerbated respiratory disease: a case series
Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), and respiratory reactions to cyclooxygenase-1 inhibitors.1  Patients with AERD have severe CRSwNP that is often refractory to standard therapies including intranasal corticosteroids2 and is associated with high utilization of healthcare resources.3 Following endoscopic sinus surgery (ESS), nasal polyp regrowth occurs within two years for 85% of patients with AERD,4 and for many patients, surgery does not provide complete resolution of symptoms.
Source: Annals of Allergy, Asthma and Immunology - December 1, 2021 Category: Allergy & Immunology Authors: Pooja Patel, Jillian C. Bensko, Neil Bhattacharyya, Tanya  M. Laidlaw, Kathleen M. Buchheit Source Type: research

Demographic Variation in Chronic Rhinosinusitis by Subtype and Region: A Systematic Review
CONCLUSIONS: Significant demographic differences exist in CRS patients based on subtype and region. These data provide an estimation of the demographic make-up of CRS, but further high-level demographic studies are needed.PMID:34825572 | DOI:10.1177/19458924211056294
Source: American Journal of Rhinology and Allergy - November 26, 2021 Category: ENT & OMF Authors: Cheng Ma Neil K Mehta Shaun A Nguyen David A Gudis Amar Miglani Rodney J Schlosser Source Type: research

Urinary leukotriene E4 is a biomarker for chronic rhinosinusitis associated with leukotriene dysregulation irrespective of aspirin sensitivity status
Source: International Forum of Allergy and Rhinology - November 25, 2021 Category: Allergy & Immunology Authors: Beau M. Idler, Devyani Lal, Michael J. Marino Tags: CLINICAL LETTER Source Type: research