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Drug: Aspirin
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Total 985 results found since Jan 2013.
Medical ID use by international patients with Aspirin-Exacerbated Respiratory Disease
Patients widely use medical identification (ID) to indicate their food and drug allergies, and chronic medical conditions. One chronic condition for which patients are recommended to use a form of medical ID i...
Source: Allergy, Asthma and Clinical Immunology - March 13, 2023 Category: Allergy & Immunology Authors: Mohammed Alqabasani, Andrea Lasso and Shaun Kilty Tags: Short report Source Type: research
Corrigendum
With regard to the article in the December 2022 issue entitled “Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization” (J Allergy Clin Immunol 2022;150:1486-97), the accession number for the original sequence data was not included. The GEO accession number is GSE219154 an d the data is available at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE219154.
Source: Journal of Allergy and Clinical Immunology - March 1, 2023 Category: Allergy & Immunology Tags: Corrigendum Source Type: research
Characteristics of chronic rhinosinusitis phenotypes in patients undergoing functional endoscopic sinus surgery: an observational cohort retrospective study
This study analyzed the characteristics of chronic rhinosinusitis patients with and without nasal polyps failing conservative treatment and undergoing functional endoscopic sinus surgery as part of their treatment for chronic inflammatory sinonasal disease. The aim of this retrospective single-institution cohort study conducted at a university hospital tertiary referral center was to evaluate the characteristics of patients with both disease phenotypes in whom conservative treatment was unsuccessful. Patients who were surgically treated with functional endoscopic sinus surgery performed by two rhinology surgeons during a o...
Source: Acta Clinica Croatica - February 23, 2023 Category: General Medicine Authors: Martina Radeti ć Jeffry Mattar Andro Ko šec Filip Bacan Tomislav Baudoin Source Type: research
Recent Updates in Understanding NSAID Hypersensitivity
AbstractPurpose of ReviewTo provide a review of available literature regarding nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with an emphasis on more recent findings.Recent FindingsOral provocation tests with aspirin are important for diagnosis and management in adult and pediatric populations with reported NSAID hypersensitivity. Risk of cross-reactivity to COX-2 inhibitors varies by NSAID hypersensitivity phenotype. COX-2 inhibitors are tolerated in aspirin-exacerbated respiratory disease. Reported NSAID allergy is associated with a higher risk of a substance use disorder. Effective treatment of underlying...
Source: Current Allergy and Asthma Reports - February 9, 2023 Category: Allergy & Immunology Source Type: research
Real-world Outcomes of Dupilumab Therapy for Nasal Polyposis in Patients with Aspirin-Exacerbated Respiratory Disease
Dupilumab has been integrated into the management of chronic rhinosinusitis with nasal polyposis (CRSwNP), but there is limited data regarding real-world use and sinonasal outcomes for patients with aspirin-exacerbated respiratory disease (AERD). The aim of this study is to investigate the sinonasal outcomes of dupilumab for patients with CRSwNP and coexistent AERD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Isaac Schmale, Alexander Poulakis, Audrey Abend, Martha Luitje, Li-Xing Man Source Type: research
Il-4 receptor alpha chain q576r rr genotype is associated with increased markers of type 2 inflammation in aspirin exacerbated respiratory disease
In the US, chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by elevated levels of IL-4 and IL-13. Several single nucleotide polymorphisms within the gene encoding for the shared IL-4 receptor alpha chain have been identified, including Q576R (c.1727A>G). The frequency of the RR genotype was significantly higher among asthmatics and the variant was associated with more severe lower airway disease. The impact of the RR genotype in CRSwNP is unclear.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Whitney Stevens, James Norton, Kris Erickson, Atsushi Kato, Lydia Suh, Roderick Carter, Julia Huang, Anju Peters, Leslie Grammer, David Conley, Stephanie Shintani Smith, Bruce Tan, Kevin Welch, Robert Kern, Carole Ober, Robert Schleimer Source Type: research
Cysteinyl Leukotrienes and Extracellular Nucleotides Mediate the Cross-talk between Platelets and Mast cells in Allergic Inflammation
Mast cells are responsible for allergic reactions by releasing a variety of mediators such as prostaglandin D2 (PGD2) and Cysteinyl leukotrienes (CysLTs). There is accumulating evidence that platelets interact with other immune cells to boost proinflammatory responses in severe asthma and Aspirin Exacerbated Respiratory Disease (AERD). However, potential cross-talk between platelets and mast cells in allergic inflammation remains unexplored.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Airi Nishida, Jun Nagai, Kinan Alhallak, Joshua Boyce Source Type: research
Perioperative Mepolizumab in Aspirin-Exacerbated Respiratory Disease Does Not Prevent Nasal Polyp Regrowth: A Case Series
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a defining feature of aspirin-exacerbated respiratory disease (AERD) and leads to impairment in quality of life. Endoscopic sinus surgery (ESS) is standard-of-care treatment for patients with refractory CRSwNP, but disease often recurs after ESS in those with AERD. We hypothesized that perioperative use of an anti-interleukin-5 antibody, mepolizumab, would prevent CRSwNP recurrence post-ESS.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Andrew Supron, Regan Bergmark, Rachel Roditi, Tanya Laidlaw, Kathleen Buchheit Source Type: research
Blow Me Away: Change in Exhaled Fractional Nitric Oxide (FeNO) Levels May Help to Identify Aspirin Exacerbated Respiratory Disease (AERD)
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a heterogenous disease. Aspirin-exacerbated respiratory disease (AERD) is a distinct CRSwNP phenotype with a unique therapeutic approach. Our study aimed to compare fractional exhaled nitric oxide (FeNO) and urinary leukotriene E4 (LTE4), before and after endoscopic sinus surgery (ESS) among CRSwNP patients with and without AERD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Mara Shapero, Tyrone Coyle, Blanka Kaplan Source Type: research
Platelet Adherent Eosinophils Drive ILC2 Expansion
Platelets are essential for leukocyte recruitment in allergic inflammation and can amplify type 2 immunopathology. Platelets contain the potent type 2 cytokine IL-33. Activated platelets adhere to circulating eosinophils in asthma and especially in aspirin-exacerbated respiratory disease (AERD). The intranasal administration of leukotriene C4 (LTC4) to ovalbumin (OVA) sensitized mice markedly increases lung eosinophilia in response to low dose (0.1%) OVA inhalation by a mechanism that requires platelets.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Hiroaki Hayashi, Jun Nagai, Tao Liu, Chunli Feng, Kendall Zaleski, Junrui Lin, Yumi Tani, Airi Nishida, Kinan Alhallak, Barbara Balestrieri, Joshua Boyce Source Type: research
Progression of Aspirin Exacerbated Respiratory Disease: A Cohort Study
In this study we characterize sequence of initial presentation, disease progression, and variation in clinical characteristics in AERD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: Kelley Dages, Olufemi Sofola-James, Esha Sehanobish, Elizabeth Ender, ROHIT DIVEKAR, Hillel Cohen, Elina Jerschow Source Type: research
The Chronic Rhinosinusitis Practice Parameter
Ann Allergy Asthma Immunol. 2022 Dec 17:S1081-1206(22)02005-1. doi: 10.1016/j.anai.2022.12.022. Online ahead of print.ABSTRACTThe Allergy-Immunology Joint Task Force on Practice Parameters has published Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines for the medical management of chronic rhinosinusitis with nasal polyposis (CRSwNP). The practice parameter provides evidence-based guidelines on the use of intranasal corticosteroids (INCS) and biologics for CRSwNP, and aspirin therapy after desensitization (ATAD) for the management of aspirin exacerbated respiratory disease (AERD). Evidenc...
Source: Annals of Allergy, Asthma and Immunology - December 20, 2022 Category: Allergy & Immunology Authors: So Lim Kim Matthew A Rank Anju Tripathi Peters Source Type: research
Reply
We thank Cornejo-Garc ía et al1 for their interest in our article "Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization."2 We agree that patient selection is important in biomarker discovery and had acknowledged the limitations in t he article. As explained in the discussion, we had adopted a pragmatic approach in patient recruitment, as the patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA) had active coronary artery disease requiring aspirin before urgent percutaneous coronary interv ention.
Source: Journal of Allergy and Clinical Immunology - December 19, 2022 Category: Allergy & Immunology Authors: Sen Hee Tay, Amelia Santosa, Bernett Teck Kwong Lee, Paul Lorenz Bigliardi Tags: Correspondence Source Type: research
Accurate phenotyping of cross-reactive hypersensitivity is essential to shed light on the underlying mechanisms in NSAID-induced urticaria/angioedema
The article "Distinct transcriptomic and metabolomic profiles characterize NSAID-induced urticaria/angioedema patients undergoing aspirin desensitization" by Tay et al1 in The Journal of Allergy and Clinical Immunology tries to characterize transcriptomic and metabolomic profiles in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced urticaria/angioedema (NIUA) who are undergoing aspirin desensitization. Patients were included exclusively on the basis of clinical history, without an aspirin drug provocation test (DPT).
Source: Journal of Allergy and Clinical Immunology - December 19, 2022 Category: Allergy & Immunology Authors: Jos é Antonio Cornejo-García, Rafael Núñez, María J. Torres, Inmaculada Doña Tags: Correspondence Source Type: research
The Chronic Rhinosinusitis Practice Parameter
The Allergy-Immunology Joint Task Force on Practice Parameters has published Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines for the medical management of chronic rhinosinusitis with nasal polyposis (CRSwNP). The practice parameter provides evidence-based guidelines on the use of intranasal corticosteroids (INCS) and biologics for CRSwNP, and aspirin therapy after desensitization (ATAD) for the management of aspirin exacerbated respiratory disease (AERD). Evidence on surgery was not assessed.
Source: Annals of Allergy, Asthma and Immunology - December 16, 2022 Category: Allergy & Immunology Authors: So Lim Kim, Matthew A. Rank, Anju Tripathi Peters Tags: Review Source Type: research
