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Emerging Biomarkers Beyond Leukotrienes for the Management of Nonsteroidal Anti-inflammatory Drug (NSAID)-Exacerbated Respiratory Disease
Allergy Asthma Immunol Res. 2022 Mar;14(2):153-167. doi: 10.4168/aair.2022.14.2.153.ABSTRACTNonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is a unique condition characterized by aspirin/NSAID hypersensitivity, adult-onset asthma, and/or chronic rhinosinusitis with nasal polyps. Arachidonic acid metabolism dysregulation and intense eosinophilic/type 2 inflammation are central mechanisms in NERD. Studies have been conducted on various biomarkers, and urinary leukotriene E4 is considered the most available biomarker of NERD. However, the pathophysiology of NERD is heterogeneous and complex....
Source: Allergy, Asthma and Immunology Research - March 7, 2022 Category: Allergy & Immunology Authors: Hyo-In Rhyou Young-Hee Nam Hae-Sim Park Source Type: research
