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Drug: Amoxicillin

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Total 392 results found since Jan 2013.

Cefuroxime, levofloxacin, esomeprazole, and bismuth as first-line therapy for eradicating Helicobacter pylori in patients allergic to penicillin
Eradicating Helicobacter pylori infection is clinically challenging, notably in cases with penicillin allergy. Cephalosporin could be used in lieu of amoxicillin to eradicate Helicobacter pylori. The current work...
Source: BMC Gastroenterology - July 25, 2019 Category: Gastroenterology Authors: Zhiqiang Song, Wei Fu and Liya Zhou Tags: Research article Source Type: research

Penicillin Allergy Evaluation: A Prospective, Multicenter, Open-Label Evaluation of a Comprehensive Penicillin Skin Test Kit
ConclusionsThe Penicillin Skin Test Kit, containing all relevant penicillin allergenic determinants, demonstrated very high NPV. Removal of a penicillin allergy label in a large majority of currently mislabeled patients has substantial personal and public health implications.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 3, 2019 Category: Allergy & Immunology Source Type: research

The Low Risks and High Rewards of Penicillin Allergy Delabeling: An Algorithm to Expedite the Evaluation
A father brings his 2 sons, ages 11 and 13 years, to an allergy clinic for testing for amoxicillin allergy. They both received amoxicillin for upper respiratory infections as toddlers, and one of them developed diarrhea. Both were labeled as penicillin allergic, but the family says both they and the pediatrician have forgotten who actually had the reaction. Their charts both carry the label of penicillin allergy.
Source: The Journal of Pediatrics - June 24, 2019 Category: Pediatrics Authors: Cathleen Collins Tags: Grand Rounds Source Type: research

Is direct oral amoxicillin challenge a viable approach for ‘low-risk’ patients labelled with penicillin allergy?
AbstractSpurious penicillin allergy (PenA) is a major public health problem. Up to 10% of the population and 20% of inpatients are labelled with PenA, but only<5% –10% have a proven allergy following comprehensive investigations. PenA tests are labour intensive and require specialist input, which may not be readily available due to limited allergy services. Therefore, patients with PenA receive alternative antibiotics that are associated with higher rates o f iatrogenic infections, antimicrobial resistance and a longer hospital stay with consequent increased costs. Recent evidence suggests that a supervised ‘direct...
Source: Journal of Antimicrobial Chemotherapy - June 5, 2019 Category: Microbiology Source Type: research

Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: A randomized, controlled trial
ConclusionsIn low risk patients, DC provided a safe and effective alternative to PST in de-labeling penicillin allergy. Compared to PST, DC may also take less time, cost less money, and lead to fewer penicillin allergy evaluations with false positive results.
Source: The Journal of Allergy and Clinical Immunology: In Practice - June 4, 2019 Category: Allergy & Immunology Source Type: research

Incidence, etiology, predictors and outcomes of suspected drug hypersensitivity reactions in a  tertiary care university hospital's emergency department : A retrospective study.
CONCLUSION: Drug hypersensitivity is a common reason for tertiary centre emergency admissions. This is the largest analysis of ED drug hypersensitivity admissions so far. Beta-lactams were identified as the leading cause of drug hypersensitivity requiring ED evaluation, which also explains the peak of drug hypersensitivity cases during winter months when the use of these medications is highest. PMID: 31037361 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - April 28, 2019 Category: General Medicine Authors: Bielen C, Bielen L, Likić R Tags: Wien Klin Wochenschr Source Type: research

The Limited Value of Prolonged Drug Challenges in Nonimmediate Amoxicillin (Clavulanic Acid) Hypersensitivity
ConclusionsA pDC is of limited added value to the diagnostic algorithms of nonimmediate hypersensitivity reaction or unclear hypersensitivity reactions to AX(/CL). In our hands, the traditionally recommended diagnostic algorithm that offers a 1-day DC as a final diagnostic in patients with negative workup for AX(/CL) is appropriate.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 27, 2019 Category: Allergy & Immunology Source Type: research

Flucloxacillin hypersensitivity: patient outcomes in a multi-center retrospective study
ConclusionsImmediate hypersensitivity reactions to flucloxacillin are more common than delayed. Cross sensitization to other penicillins appears higher in delayed reactions than in immediate. The NPV of intradermal testing is higher in the immediate than non-immediate group. Drug provocation testing remains the diagnostic gold standard.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 26, 2019 Category: Allergy & Immunology Source Type: research

Identifying Low-risk Beta-Lactam allergy Patients in a UK Tertiary Centre
ConclusionWe identified a “low risk” cohort of patients where the history is of similar reliability to skin testing in predicting non-allergic status for BL allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 26, 2019 Category: Allergy & Immunology Source Type: research

Evaluating Penicillin Allergies Without Skin Testing
AbstractPurpose of ReviewAn unconfirmed penicillin allergy is known to confer significant risk to patients. Only a small minority of patients labeled with penicillin allergy will be confirmed to be hypersensitive with the current reference standard test, an oral amoxicillin therapeutic dose challenge. Skin testing has been recommended prior to oral challenges to reduce the risk of severe acute challenge reactions. The rate of severe acute anaphylactic reactions with oral amoxicillin is currently extremely low. Unfortunately, penicillin skin testing, as commonly performed, has a high rate of false positive results.Recent Fi...
Source: Current Allergy and Asthma Reports - March 21, 2019 Category: Allergy & Immunology Source Type: research

Penicillin allergy evaluation: A prospective, multicenter, open label evaluation of a comprehensive penicillin skin test kit
ConclusionThe Penicillin Skin Test Kit, containing all relevant penicillin allergenic determinants, demonstrated very high NPV. Removal of a penicillin allergy label in a large majority of currently mislabeled patients has substantial personal and public health implications.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 14, 2019 Category: Allergy & Immunology Source Type: research

Amoxicillin sensitization rate in patients with eruptions after Helicobacter pylori eradication therapy
I read with interest the recent article by Ito et  al.1 The authors reported that only 2 of 15 patients with skin eruptions after eradication therapy for Helicobacter pylori using amoxicillin, clarithromycin, and a proton pump inhibitor had positive results on repeated drug lymphocyte transformation tests (LTTs), and in another patient CD4+ T cell s expressed CD154 in response to the drugs. They elegantly demonstrated that a significant proportion of the patients with negative drug-specific responses (9/12) exhibited H pylori–specific immune responses.
Source: Journal of Allergy and Clinical Immunology - March 12, 2019 Category: Allergy & Immunology Authors: Kazuhiro Kawai Tags: Correspondence Source Type: research

Drug Induced Enterocolitis Syndrome (DIES): a clinical entity which deserves more awareness
Drug induced enterocolitis syndrome (DIES) is a rare, non-IgE mediated hypersensitivity reaction provoked by drugs which can be severe and lead to shock. Despite the potential severity of the reactions, awareness of DIES is low. In contrast, enterocolitis syndrome induced by food proteins (FPIES) has been better documented. Previous studies have reported the occurrence of hypovolemic shock in approximately 15% of reactions, which indicates that FPIES is a potentially life threating disease.(1) To increase clinical awareness on DIES we here report a case of a child who was referred to our pediatric allergy clinic and was di...
Source: Annals of Allergy, Asthma and Immunology - February 14, 2019 Category: Allergy & Immunology Authors: A.O.J. Van Thuijl, L.J. Landzaat, O. Liem, J.A.M. Emons, N.J.T. Arends Tags: Letters Source Type: research

Drug-induced enterocolitis syndrome (DIES)
is a rare, non –IgE-mediated hypersensitivity reaction provoked by drugs that can be severe and lead to shock. Despite the potential severity of the reactions, awareness of DIES is low. In contrast, enterocolitis syndrome induced by food proteins (FPIES) has been better documented. Previous studies have reported the occurrence of hypovolemic shock in approximately 15% of reactions, which indicates that FPIES is a potentially life-threating disease.1 To increase clinical awareness of DIES, we report a case of a child who was referred to our pediatric allergy clinic and was diagnosed with DIES by amoxicillin .
Source: Annals of Allergy, Asthma and Immunology - February 13, 2019 Category: Allergy & Immunology Authors: Anders O.J. Van Thuijl, Lonneke J. Landzaat, Olivia Liem, Joyce A.M. Emons, Nicolette J.T. Arends Tags: Letters Source Type: research

Effect of commercial nasal steroid preparation on bacterial growth
ConclusionThe commercial product Pulmicort has a direct antibacterial effect on the planktonic and biofilm forms ofS aureus and MRSA. This effect is at least in part mediated through the excipient EDTA in the product. Excipients also influenced the antimicrobial activity of antibiotics depending on the bacterial strain and antibiotic tested.
Source: International Forum of Allergy and Rhinology - February 12, 2019 Category: Allergy & Immunology Authors: Lisa Mary Cherian, Clare Cooksley, Katharina Richter, Mahnaz Ramezanpour, Sathish Paramasivan, Peter ‐John Wormald, Sarah Vreugde, Alkis James Psaltis Tags: ORIGINAL ARTICLE Source Type: research