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Total 392 results found since Jan 2013.

Allergy test outcomes in patients self-reported as having penicillin allergy: Two-year experience.
CONCLUSION: Only 28.6% of patients with self-reported penicillin allergy were confirmed to be allergic. Importantly, when the index drug is amoxicillin-clavulanic acid or flucloxacillin, the patients may tolerate amoxicillin. PMID: 27613461 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Meng J, Thursfield D, Lukawska JJ Tags: Ann Allergy Asthma Immunol Source Type: research

Pre-Operative Penicillin Allergy Testing in Cardiac Surgery Patients.
CONCLUSION: Integrating penicillin allergy evaluation into routine pre-operative care ensured that almost all cardiac surgery patients evaluated received first-line antibiotic prophylaxis, a critical component of SSI risk reduction. Further efforts are needed to increase access to pre-operative allergy evaluation. PMID: 32217188 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 22, 2020 Category: Allergy & Immunology Authors: Plager JH, Mancini CM, Fu X, Melnitchouk S, Shenoy ES, Banerji A, Collier L, Chaudhary N, Yerneni S, Zhang Y, Blumenthal KG Tags: Ann Allergy Asthma Immunol Source Type: research

Intrapartum antibiotic exposure for group B Streptococcus treatment did not increase penicillin allergy in children.
CONCLUSION: To the authors' knowledge, this is the first study to evaluate intrapartum exposure to penicillin for GBS treatment and subsequent development of penicillin allergy in the child. In contrast to other atopic diseases, intrapartum antibiotic exposure does not alter the risk of penicillin allergy. Parents and obstetricians should be reassured when using penicillin for prevention of neonatal GBS. PMID: 26815706 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 28, 2016 Category: Allergy & Immunology Authors: May SM, Hartz MF, Joshi AY, Park MA Tags: Ann Allergy Asthma Immunol Source Type: research

Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests ✰,✰✰,✰✰✰.
CONCLUSION: Conventional predictors of allergy to penicillin performed weakly. The authors propose straightforward penicillin provocation testing in controlled, experienced centers for the diagnosis of non-severe penicillin allergy in children. PMID: 29803713 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 24, 2018 Category: Allergy & Immunology Authors: Ibáñez MD, Del Río PR, Lasa EM, Joral A, Ruiz-Hornillos J, Muñoz C, Traseira CG, Escudero C, Olaguibel Rivera JM, Garriga-Baraut T, González-de-Olano D, Rosado A, Sanchez-García S, Bustamante SP, Vilchez MAP, Montaño PP, Morillo RC, Iglesia EM, Vil Tags: Ann Allergy Asthma Immunol Source Type: research

Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs
Purpose of review: Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and outpatient settings, and minimize false-positive determinations. This review concentrates on articles published in 2013 and 2014 that present new data relating to the diagnosis and management of penicillin allergy. Recent findings: Penicillin allergy can be safely evaluated at this time, in patients with an ap...
Source: Current Opinion in Allergy and Clinical Immunology - June 26, 2015 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Bernard Y.-H. Thong Source Type: research

The Negative Predictive Value of 5-Day Drug Provocation Test in Nonimmediate Beta-Lactam Allergy in Children.
CONCLUSION: The 5-day prolonged DPT has high NPV and seems appropriate in duration for children with suspected nonimmediate-BLA allergy. PMID: 31923549 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 6, 2020 Category: Allergy & Immunology Authors: Celik IK, Guvenir H, Hurmuzlu S, Toyran M, Civelek E, Kocabas CN, Misirlioglu ED Tags: Ann Allergy Asthma Immunol Source Type: research

Skin testing and oral amoxicillin challenge in the outpatient allergy and clinical immunology clinic in penicillin-allergic pregnant women.
CONCLUSION: Penicillin skin testing and oral challenge in pregnant women can safely be performed in the outpatient setting. There was no difference in intrapartum antibiotic use between women who were or were not challenged. Further research is needed to determine the utility of oral challenge in pregnant patients. PMID: 32798617 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - August 12, 2020 Category: Allergy & Immunology Authors: Kuder MM, Lennox MG, Li M, Lang DM, Pien L Tags: Ann Allergy Asthma Immunol Source Type: research

One-year survey of paediatric anaphylaxis in an allergy department.
CONCLUSIONS: In our paediatric population, the main triggering agent of anaphylaxis was IgE-mediated food allergy. Epinephrine is underused, as reported by others. Often, children have several episodes before being assessed by an allergist. We stress the importance of systematic notification and improvement of educational programmes in order to achieve a better preventive and therapeutic management of this life-threatening entity. PMID: 26549337 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - November 11, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation.
CONCLUSION: This study found a high rate of exclusively positive skin test reactions to the minor determinants penicilloate and penilloate. Because patients with positive test reactions are at increased risk of reaction to drug challenge, these data support the use of these reagents for penicillin skin testing in hospitalized patients. PMID: 28743423 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - July 22, 2017 Category: Allergy & Immunology Authors: Geng B, Eastman JJ, Mori K, Braskett M, Riedl MA Tags: Ann Allergy Asthma Immunol Source Type: research

A UK national survey of investigations for beta lactam hypersensitivity ‐ heterogeneity in practice and a need for national guidelines ‐ On behalf of British Society for Allergy and Clinical Immunology (BSACI)
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - April 23, 2013 Category: Allergy & Immunology Authors: AG Richter, SM Nasser, MT Krishna Tags: Original Article‐Clinical Allergy Source Type: research

Direct Amoxicillin Challenge without Preliminary Skin Testing for Pediatric Patients with Penicillin Allergy Labels.
PMID: 32407949 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 10, 2020 Category: Allergy & Immunology Authors: Wang LA, Patel K, Kuruvilla ME, Shih J Tags: Ann Allergy Asthma Immunol Source Type: research

Penicillin and Beta-Lactam Allergy: Epidemiology and Diagnosis
Abstract Penicillin is the most common beta-lactam antibiotic allergy and the most common drug class allergy, reported in about 8 % of individuals using health care in the USA. Only about 1 % of individuals using health care in the USA have a cephalosporin allergy noted in their medical record, and other specific non-penicillin, non-cephalosporin beta-lactam allergies are even rarer. Most reported penicillin allergy is not associated with clinically significant IgE-mediated reactions after penicillin rechallenge. Un-verified penicillin allergy is a significant and growing public health problem. Clinically signi...
Source: Current Allergy and Asthma Reports - September 13, 2014 Category: Allergy & Immunology Source Type: research

Safety and Outcomes of Penicillin Allergy Evaluation in Pregnant Women
CONCLUSION: PST and IDC can be safely conducted in pregnant women. When evaluated as low risk, the majority of women tolerate IDC and can receive penicillin intrapartum without adverse reactions or negative pregnancy outcomes.PMID:35123076 | DOI:10.1016/j.anai.2022.01.032
Source: Annals of Allergy, Asthma and Immunology - February 5, 2022 Category: Allergy & Immunology Authors: Vima Patel Patrick K Gleeson Kathryn Delaney Steven J Ralston Scott Feldman Olajumoke Fadugba Source Type: research

Clinical Outcomes following Inpatient Penicillin Allergy Testing: A Systematic Review and Meta ‐analysis
ConclusionsInpatient penicillin allergy testing is safe and effective in ruling out penicillin allergy. The rate of negative tests is comparable to outpatient and perioperative data. Patients with a documented penicillin allergy who require penicillin should be tested during hospitalization given its benefit for individual patient outcomes and antibiotic stewardship.This article is protected by copyright. All rights reserved.
Source: Allergy - March 29, 2017 Category: Allergy & Immunology Authors: Keith A. Sacco, Allan Bates, Tara J. Brigham, J. Saadi ‐Imam, M Caroline Burton Tags: Review Source Type: research