The Low Risks and High Rewards of Penicillin Allergy Delabeling: An Algorithm to Expedite the Evaluation
A father brings his 2 sons, ages 11 and 13 years, to an allergy clinic for testing for amoxicillin allergy. They both received amoxicillin for upper respiratory infections as toddlers, and one of them developed diarrhea. Both were labeled as penicillin allergic, but the family says both they and the pediatrician have forgotten who actually had the reaction. Their charts both carry the label of penicillin allergy.
Contributors : Ang A Tu ; Todd M Gierahn ; Brinda Monian ; Duncan M Morgan ; Naveen K Mehta ; Bert Ruiter ; Wayne G Shreffler ; Alex K Shalek ; J C LoveSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh-throughput 3 ′ single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individualimmune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features,including variable sequences of T cell antigen receptors (TCRs) that confer antigen specificity. Here, we present a strategy thatenable...
Government officials say the objective is to encourage competition and reduce costs
Doctors were stumped, until a pulmonologist asked about feather bedding in the man's home.
Concerns over staffing needs and the risk for anaphylaxis with new oral immunotherapies have physicians questioning the next steps.Medscape Medical News
Date: Thursday, 12 12, 2019; Speaker: Polly Ferguson, MD, Director, Pediatric Rheumatology, Allergy and Immunology, University of Iowa Carver College of Medicine ; Building 10, FAES Room 7; B1C206
ConclusionsIn CSU the likelihood of clinical improvement from laboratory testing is very low, and testing not cost-effective. These data support recommendations to not routinely perform laboratory testing in CSU patients with otherwise normal histories and physical evaluations.
ConclusionsCSU has strong negative effects on female sexual function, especially in patients with angioedema. Additional studies on sexual health in patients with CSU are needed and should focus on the impact of effective treatment on sexual functioning.
Publication date: Available online 18 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Tomas Moraly, Diane Pelletier de Chambure, Stephane Verdun, Christian Preda, Maxime Seynave, Anne-Christine Vilain, Cecile Chenivesse, Christine Delebarre-SauvageAbstractBackgroundOral immunotherapy (OIT) protects patients with IgE-mediated food allergies from food-induced allergic reactions due to accidental exposure and may improve their quality of life. This approach has never been evaluated for hazelnut, a major cause of food allergy in Europe.ObjectiveWe sought to determine the proportion of...
Publication date: Available online 18 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Puja Sood Rajani, Hayley Martin, Marion Groetch, Kirsi M. JärvinenAbstractBreastfeeding is currently recommended as the optimal source of nutrition to infants. However, there are several studies that have shown clinical IgE and non-IgE-mediated reactions to foods in exclusively breastfeeding infants, specifically to cow’s milk, egg, peanut, and fish. Literature suggests that antigenic food proteins present in human milk can be found in substantial enough amounts to elicit clinical reac...
After a devastating fire, a family practice physician creates a one-of-a-kind dream clinic where everyone is welcome.Medscape Medical News