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Total 25 results found since Jan 2013.

Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case-control study
Eur J Epidemiol. 2022 Feb 3. doi: 10.1007/s10654-022-00843-y. Online ahead of print.ABSTRACTWe investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case-control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for education and time at interview. Reduced ORs were observed for glioma in relation to physician-diagnosed asthma (OR = 0.7...
Source: Cancer Control - February 4, 2022 Category: Cancer & Oncology Authors: Brigitte Schlehofer Maria Blettner Monika Moissonnier Isabelle Deltour Graham G Giles Bruce Armstrong Jack Siemiatycki Marie-Elise Parent Daniel Krewski Christoffer Johansen Anssi Auvinen Anna Lahkola Martine Hours Gabriele Berg-Beckhoff Siegal Sadetzki S Source Type: research

Association of allergic diseases and epilepsy with risk of glioma, meningioma and acoustic neuroma: results from the INTERPHONE international case –control study
AbstractWe investigated the association of allergic diseases and epilepsy with risk of brain tumours, in Interphone, a 13-country case –control study. Data were obtained from 2693 glioma cases, 2396 meningioma cases, and 1102 acoustic neuroma cases and their 6321 controls. Conditional logistic regression models were used to estimate pooled odds ratios (ORs) and their respective 95% confidence intervals (CIs), adjusted for educati on and time at interview. Reduced ORs were observed for glioma in relation to physician-diagnosed asthma (OR = 0.73;CI 0.58 –0.92), hay fever (OR 0.72;CI 0.61 –0.86), and eczema (OR 0.78...
Source: European Journal of Epidemiology - February 3, 2022 Category: Epidemiology Source Type: research

Pre ‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples
In a nested case –control study, we found that the pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα and sIL-6R were associated with glioma risk. Our findings suggest these proteins play important roles in gliomagenesis. AbstractNo strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre-diagnostic immune protein levels and glioma risk. We conducted a case –control study nested in the Northern Sweden Health and Disease Study cohort. We analysed...
Source: Cancer Medicine - January 14, 2022 Category: Cancer & Oncology Authors: Wendy Yi ‐Ying Wu, Florentin Späth, Carl Wibom, Benny Björkblom, Anna M. Dahlin, Beatrice Melin Tags: RESEARCH ARTICLE Source Type: research

History of atopy confers improved outcomes in IDH mutant and wildtype lower grade gliomas
ConclusionA history of atopy confers a survival benefit in patients with diffuse low-grade glioma. Activation of the BDNF pathway may drive the observed differences.
Source: Journal of Neuro-Oncology - October 29, 2021 Category: Cancer & Oncology Source Type: research

Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma
The immune system is increasingly recognized as a key player in glioma pathobiology. Small case ‐control studies have found inverse associations between autoimmune diseases and glioma incidence. We performed a large case‐control study, which did not replicate these associations. However, our data indicate that inflammatory bowel disease (IBD) among patients ≤40 years are associated with an increased risk of glioma. Further studies are needed to explore the role of IBD and altered microbiota in glioma. AbstractEffectors from the immune system can modulate the course and possibly the early development of gliomas. We, ...
Source: Cancer Medicine - December 9, 2019 Category: Cancer & Oncology Authors: Tareq M. Anssar, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Katharina Sahm, Michael Platten, Peter Hau, Corinna Seliger Tags: ORIGINAL RESEARCH Source Type: research

Cancers, Vol. 11, Pages 404: Allergic Signs in Glioma Pathology: Current Knowledge and Future Perspectives
aro Historically restrained to immune defense against parasite infections, allergic inflammation has been recently rediscovered to protect from a wide array of environmental triggers, such as xenobiotics and carcinogens, which can induce DNA damage and ultimately lead to cancer development. Moreover, cells and mediators typical of allergic responses can importantly modulate the tissue inflammatory milieu, which represents a crucial gatekeeper towards the acquisition of malignancy by cancer cells through immune escape. Numerous studies have described an inverse association between allergies and glioma development. Mast ...
Source: Cancers - March 21, 2019 Category: Cancer & Oncology Authors: Massimo Costanza Gaetano Finocchiaro Tags: Review Source Type: research

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
ConclusionsIn this Swedish glioma case –control cohort, we identified that long rLTL increases the risk of glioma, an association not confounded by allergy, BMI, or smoking. This highlights the complex interplay of the immune system, rLTL and cancer risk.
Source: Cancer Causes and Control - December 17, 2018 Category: Cancer & Oncology Source Type: research

Epidemiology and Molecular Epidemiology
Incidence, prevalence, and survival for diffuse low-grade gliomas and diffuse anaplastic gliomas (including grade II and grade III astrocytomas and oligodendrogliomas) varies by histologic type, age at diagnosis, sex, and race/ethnicity. Significant progress has been made in identifying potential risk factors for glioma, although more research is warranted. The strongest risk factors that have been identified thus far include allergies/atopic disease, ionizing radiation, and heritable genetic factors. Further analysis of large, multicenter epidemiologic studies, and well-annotated “omic” datasets, can potentially lead ...
Source: Neurosurgery Clinics of North America - November 21, 2018 Category: Neurosurgery Authors: Luc Bauchet, Quinn T. Ostrom Source Type: research

Impact of atopy on risk of glioma: a Mendelian randomisation study
An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to ...
Source: BMC Medicine - March 15, 2018 Category: Internal Medicine Authors: Linden Disney-Hogg, Alex J. Cornish, Amit Sud, Philip J. Law, Ben Kinnersley, Daniel I. Jacobs, Quinn T. Ostrom, Karim Labreche, Jeanette E. Eckel-Passow, Georgina N. Armstrong, Elizabeth B. Claus, Dora Il ’yasova, Joellen Schildkraut, Jill S. Barnholtz Tags: Research article Source Type: research

Antiproliferative Effect of Synadenium grantii Hook f. stems (Euphorbiaceae) and a Rare Phorbol Diterpene Ester
Synadenium grantii is frequently used for the treatment of various diseases such as allergies, gastric disorders, and especially cancer. The aim of this study was to evaluate the possible antiproliferative potential of the methanol extract, fractions, and pure compounds from the stems of S grantii. Phytochemical analysis was carried out by conventional chromatographic techniques, and the antiproliferative activity was analyzed using the sulforhodamine B assay and an MTT-based assay. Nonpolar fraction and its subfractions from the stems of S grantii exhibited promising cytostatic effect against several human tumor cell line...
Source: International Journal of Toxicology - December 1, 2016 Category: Toxicology Authors: Campos, A., Vendramini-Costa, D. B., Longato, G. B., Zermiani, T., Ruiz, A. L. T. G., de Carvalho, J. E., Pandiella, A., Cechinel Filho, V. Tags: Regular Articles Source Type: research