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Neuro-oncology: An inverse link between allergies and glioma
Nature Reviews Neurology 12, 126 (2016). doi:10.1038/nrneurol.2016.23 Author: Heather Wood A recent report from the Glioma International Case–Control Study (GICC) corroborates evidence of a reduced risk of glioma in people with allergies. According to the GICC, which includes 4,533 patients with glioma and 4,171 controls, the risk of glioma is decreased by around 30% in
Source: Nature Reviews Neurology - February 26, 2016 Category: Neurology Authors: Heather Wood Tags: Research Highlight Source Type: research

News Association between allergies and reduced risk of glioma
Authors of a new study have noted an inverse association between the risk of developing glioma and a history of allergies. The researchers drew data from the Glioma International Case Control Study, which contains detailed information about atopic disorders for 4533 cases and 4171 controls in 14 sites and five countries. They concluded that a history of respiratory allergies reduces the risk of developing glioma (meta-analysis odds ratio 0·72 [95% CI 0·58–0·90]), as does having asthma (OR 0·77 [0·64–0·93]) and eczema (OR 0·71 [0·56–0·89]), compared with patients without allergies.
Source: The Lancet Oncology - February 11, 2016 Category: Cancer & Oncology Authors: Talha Khan Burki Tags: News Source Type: research

Consensus on Allergies and Glioma
Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention. Cancer Epidemiol Biomarkers Prev; 25(2); 282–90. ©2016 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - February 4, 2016 Category: Cancer & Oncology Authors: Amirian, E. S., Zhou, R., Wrensch, M. R., Olson, S. H., Scheurer, M. E., Il'yasova, D., Lachance, D., Armstrong, G. N., McCoy, L. S., Lau, C. C., Claus, E. B., Barnholtz-Sloan, J. S., Schildkraut, J., Ali-Osman, F., Sadetzki, S., Johansen, C., Houlston, R Tags: Research Articles Source Type: research

Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1
Abstract Individuals with Neurofibromatosis type 1 (NF1) are at increased risk for pediatric brain tumors (PBTs), especially optic gliomas; however, factors influencing their development are largely unknown. Extensive research suggests that allergic conditions protect against brain tumors, particularly gliomas in individuals without NF1. In this large cross-sectional study, we employed two different data sources to evaluate evidence for the hypothesis that allergic conditions (allergies, asthma, and eczema) may protect against PBT development in individuals with NF1. We used self- and parent/legal guardian reporte...
Source: Familial Cancer - December 14, 2015 Category: Cancer & Oncology Source Type: research

Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone
We present two patients with glioblastoma multiforme who developed severe hemolytic anemia shortly after initiating therapy with vorinostat, a pan-active histone deacetylase inhibitor, while on prophylactic dapsone. There are several potential mechanisms by which histone deacetylase inhibition may alter dapsone metabolism including changes in hepatic acetylation or N-glucuronidation leading to an increase in the bioavailability of dapsone’s hematotoxic metabolites. In addition, vorinostat may lead to increased hemolysis through inhibition of heat shock protein-90, a chaperone protein that maintains the integrity of t...
Source: Journal of Oncology Pharmacy Practice - May 5, 2015 Category: Cancer & Oncology Authors: Lewis, J. A., Petty, W. J., Harmon, M., Peacock, J. E., Valente, K., Owen, J., Pirmohamed, M., Lesser, G. J. Tags: Case Reports Source Type: research

Serum macrophage‐derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time
This article is protected by copyright. All rights reserved.
Source: International Journal of Cancer - January 21, 2015 Category: Cancer & Oncology Authors: Mi Zhou, Paige M. Bracci, Lucie S. McCoy, George Hsuang, Joseph L. Wiemels, Terri Rice, Shichun Zheng, Karl T. Kelsey, Margaret R. Wrensch, John K. Wiencke Tags: Tumor Immunology Source Type: research

A Pooled Multisite Analysis of the Effects of Atopic Medical Conditions in Glioma Risk in Different Ethnic Groups
The incidences of atopic conditions (allergies, asthma or eczema) and glioma vary by ethnicity. Atopic conditions are inversely associated with gliomas. We conducted a pooled multi-site study investigating the associations of atopic conditions with glioma in different race/ethnicity groups.
Source: Annals of Epidemiology - January 2, 2015 Category: Epidemiology Authors: Bhuma Krishnamachari, Dora Il’yasova, Michael E. Scheurer, Melissa Bondy, Renke Zhou, Margaret Wrensch, Faith Davis Source Type: research

Increased rate of positive penicillin skin tests among patients with glioma: insights into the association between allergies and glioma risk.
Conclusions In contrast to previously reported relationships between allergy and glioma, in the present study a significantly higher rate of positive PenSTs and higher eosinophil counts were found in patients with glioma than in nontumor controls. These results suggest a complex relationship between allergies and glioma development. PMID: 25170669 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - August 29, 2014 Category: Neurosurgery Authors: Han S, Huang Y, Wang Z, Li Z, Qin X, Wu A Tags: J Neurosurg Source Type: research

Interaction of allergy history and antibodies to specific varicella‐zoster virus proteins on glioma risk
Glioma is the most common cancer of the central nervous system but with few confirmed risk factors. It has been inversely associated with chicken pox, shingles and seroreactivity to varicella virus (VZV), as well as to allergies and allergy‐associated IgE. The role of antibody reactivity against individual VZV antigens has not been assessed. Ten VZV‐related proteins, selected for high immunogenicity or known function, were synthesized and used as targets for antibody measurements in the sera of 143 glioma cases and 131 healthy controls selected from the San Francisco Bay Area Adult Glioma Study. Glioma cases exhibited ...
Source: International Journal of Cancer - October 31, 2013 Category: Cancer & Oncology Authors: Seung‐Tae Lee, Paige Bracci, Mi Zhou, Terri Rice, John Wiencke, Margaret Wrensch, Joseph Wiemels Tags: Epidemiology Source Type: research

Interaction of allergy history and antibodies to specific Varicella zoster virus proteins on glioma risk
Abstract Glioma is the most common cancer of the central nervous system but with few confirmed risk factors. Glioma has been inversely associated with chicken pox, shingles, and seroreactivity to varicella virus (VZV), as well as to allergies and allergy‐associated IgE. The role of antibody reactivity against individual VZV antigens has not been assessed. Ten VZV‐related proteins, selected for high immunogenicity or known function, were synthesized and used as targets for antibody measurements in the sera of 143 glioma cases and 131 healthy controls selected from the San Francisco Bay Area Adult Glioma Study. Glioma ca...
Source: International Journal of Cancer - October 11, 2013 Category: Cancer & Oncology Authors: Seung‐Tae Lee, Paige Bracci, Mi Zhou, Terri Rice, John Wiencke, Margaret Wrensch, Joseph Wiemels Tags: Epidemiology Source Type: research

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