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2017 ’ s Year In Health News: Medical Breakthroughs, Opioid Crisis And More
CBS Local — There’s been plenty of progress in the medical world this year, and as a result we now know that more Americans than ever have high blood pressure, but also that coffee everyday is actually good for you. Here’s a look back at the year in health. Opioid Crisis The opioid crisis has dominated much of the health news cycle. President Trump declared the opioid crisis a national emergency earlier this year. Drug overdoses are now the leading cause of death for people under 50 in the United States. New Guidelines for High Blood Pressure The American Heart Association revised its guidelines for high ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 20, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News best of 2017 Samantha Lazarus Bennet Source Type: news

Two weeks to bowel cancer?
There’s no doubt antibiotics have saved a lot of lives. But because they’ve been overprescribed for so many years we’ve ended up with a slew of health problems. For one thing, overuse of antibiotics wreaks havoc on your microbiome… That’s your body’s ecosystem. Your microbiome has 100 trillion or so bacteria, viruses and fungi. It affects just about every organ and body system. Some of these gut bugs cause disease and infection. But other good bacteria are called “probiotics.” They boost your immune system. They help you digest your food and turn it into vitamins. But in ...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Randall Hall Tags: Cancer Health Men's Health Source Type: news

6 Reasons Why Owning A Dog Is Good For Your Health
Having a dog offers companionship, gives you an excuse to exercise, brings you happiness and provides entertainment. But did you know that owning a dog can also have potential health benefits, both mentally and physically, for you and your family? There is scientific evidence that touts some of the health perks of owning a pup. Take a look at how these six ways having a dog could be good for your health. 1. Stay active Dogs need to be exercised. They can’t be cooped up all day without having the chance to get up and run around. Having a dog encourages owners to take them for walks, play fetch, and get moving. And we all...
Source: Healthy Living - The Huffington Post - May 3, 2017 Category: Consumer Health News Source Type: news

New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines
Conclusion Fourteen compounds were isolated from chloroform fraction of G. mangostana fruit hulls. Cytotoxic properties exhibited by the isolated xanthones from G. mangostana reinforce the avail of it as a natural cytotoxic agent against various cancers. These evidences could provide relevant bases for the scientific rationale of using G. mangostana in anti-cancer treatment. Graphical abstract
Source: Journal of Ethnopharmacology - January 25, 2017 Category: Drugs & Pharmacology Source Type: research

Allergies and risk of colorectal cancer: a systematic review and meta-analysis of observational studies.
Authors: Ye J, Talaiti A, Ma Y, Zhang Q, Ma L, Zheng H Abstract A history of allergy or allergic condition has been reported to be associated with reduced risk of some types of malignancies. However, the understanding of this association for colorectal cancer (CRC) is controversial. We conducted a meta-analysis of CRC risk in individuals who had history of allergy compared to those without the history of allergic condition. Pumbed and Embase databases were searched for relevant studies. The adjusted relative risk (RR) and 95% confidence interval (CI) were pooled using the random-effects model. Nine studies, includi...
Source: Oncotarget - January 15, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Antihistamines as promising drugs in cancer therapy
Publication date: Available online 14 December 2016 Source:Life Sciences Author(s): Ana I. Faustino-Rocha, Rita Ferreira, Adelina Gama, Paula A. Oliveira, Mário Ginja Histamine is a biogenic amine, synthetized and released by mast cells, which acts as a vasodilator in several pathologic processes, namely in allergies and conjunctivitis. Its role on cancer is not fully understood. High levels of histamine have been associated with a bivalent behavior in regulation of several tumors (i.e. cervical, ovarian, vaginal, uterine, vulvar, colorectal cancer, and melanoma), promoting or inhibiting their growth. Histamine receptors...
Source: Life Sciences - December 13, 2016 Category: Biology Source Type: research

Acne during adolescence did not predict skin rash reaction to cetuximab
Cetuximab, a monoclonal antibody, is a part of the treatment for metastatic colorectal cancer. The most common side effect of cetuximab is skin rash, which has a similar distribution to acne vulgaris and some overlapping pathophysiological mechanisms. The aim of the current study was to determine whether acne vulgaris in adolescence (AinA) is predictive of a cetuximab-related rash to better understand the pathogenesis of this side effect and explore potential preventive actions. From July 2013 to June 2015, patients with metastatic colorectal cancer planned for treatment with cetuximab were enrolled in the study. Before in...
Source: Anti-Cancer Drugs - September 27, 2016 Category: Cancer & Oncology Tags: Clinical Reports Source Type: research

Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling.
In this study, we found that TCTP was overexpressed in the interstitial tissue of colorectal cancer (CRC) and its expression correlated with poor survival, high pathological grades and metastatic TNM stage in CRC patients. TCTP expression was greater in metastatic liver tissue than in primary tumors and was increased in highly invasive CRC cells. We demonstrated that the expression of TCTP was regulated by HIF-1α and its release was increased in response to low serum and hypoxic stress. Recombinant human TCTP (rhTCTP) promoted the migration and invasiveness of CRC cells in vitro and contributed to distant liver metastasis...
Source: Oncotarget - July 2, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Paricalcitol attenuates lipopolysaccharide-induced myocardial inflammation by regulating the NF-κB signaling pathway.
Abstract Vitamin D deficiency is associated with an increased risk of cardiovascular disease, diabetes, colon and breast cancer, infectious diseases and allergies. Vascular alterations are an important pathophysiological mechanism of sepsis. Experimental data suggest that paricalcitol, a vitamin D2 analogue, exerts beneficial effects on renal inflammation and fibrosis. In the present study, we aimed to investigate the effects of paricalcitol on lipopolysaccharide (LPS)-induced myocardial inflammation and to elucidate the underlying mechanisms. We used primary cultured human umbilical vein endothelial cells forÂ...
Source: International Journal of Molecular Medicine - March 4, 2016 Category: Molecular Biology Authors: Lee AS, Jung YJ, Thanh TN, Lee S, Kim W, Kang KP, Park SK Tags: Int J Mol Med Source Type: research

Eosinophils in cancer: favourable or unfavourable?
Abstract Eosinophils are granulocytic leukocytes residing in blood and tissues in the lung, breast, gastrointestinal and reproductive systems. Eosinophilia is uncommon in healthy individuals, however, it is associated with allergies, helminth infections and some inflammatory states. Eosinophilia has also been observed in cancer, including colorectal, breast, ovarian, cervical, oral squamous, Hodgkin's lymphoma and prostate cancer. Whether an increase in eosinophils leads to a favourable or unfavourable prognosis still remains controversial and depends on many factors including the type of cancer. Eosinophil infilt...
Source: Current Medicinal Chemistry - January 18, 2016 Category: Chemistry Authors: Sakkal S, Miller S, Apostolopoulos V, Nurgali K Tags: Curr Med Chem Source Type: research

Pharmaceutical Approval Update.
Authors: Gohil K Abstract Deoxycholic acid (Kybella) for submental fat; codeine polistirex/chlorpheniramine polistirex extended-release (Tuzistra XR) for coughs, allergies, and colds; ramucirumab (Cyramza) for colorectal cancer; and fluticasone furoate/vilanterol (Breo Ellipta) for asthma. PMID: 26185402 [PubMed]
Source: P and T - December 12, 2015 Category: Drugs & Pharmacology Tags: P T Source Type: research

My Body Makes My Brain Look Like an Idiot...
I'm getting older. I hurt more. I creak more. My ankles sound like they're each having their own personal fireworks display every single morning when I walk downstairs to feed the dog. He's getting old, too. We commiserate. "Another gray hair?" I tease. "Pot, meet kettle," he'd respond if he could. Touché, Bear. Each day brings a new malady, depending on what I eat, how I exercise, how much sleep I get, or if I have one too many glasses of wine. My liver has given up having even a shred of compassion for my unintelligence. And for some reason, my allergies whalloped me very hard this year. I can tolerate almost anythi...
Source: Healthy Living - The Huffington Post - June 16, 2015 Category: Consumer Health News Source Type: news

The Case Files: A Case of Hip Pain Masquerading a More Serious Problem
By Moises, Moreno DO; Glantz, Sanford DO   A 66-year-old woman with a history of osteoarthritis presented to the emergency department with progressively worsening left hip pain that had started five days prior to arrival. The pain was non-radiating and worse with movement, and it was associated with chills and anorexia. She had progressive difficulty walking because of pain. She had not had similar symptoms in the past, and attributed her pain to osteoarthritis. She denied recent trauma, back pain, leg swelling, numbness, and paresthesias. She also denied fever, abdominal pain and distention, nausea, vomiting, diarrhea, ...
Source: The Case Files - July 8, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Emerging roles of lactic acid bacteria in protection against colorectal cancer.
Abstract Colorectal cancer (CRC) is the third leading cause of cancer deaths worldwide and the fourth most common cancer diagnosed among men and women in the United States. Considering the risk factors of CRC, dietary therapy has become one of the most effective approaches in reducing CRC morbidity and mortality. The use of probiotics is increasing in popularity for both the prevention and treatment of a variety of diseases. As the most common types of microbes used as probiotics, lactic acid bacteria (LAB) are comprised of an ecologically diverse group of microorganisms united by formation of lactic acid as the p...
Source: World Journal of Gastroenterology : WJG - June 28, 2014 Category: Gastroenterology Authors: Zhong L, Zhang X, Covasa M Tags: World J Gastroenterol Source Type: research

April eFactor
SOT 2014 — packed with good science, energy, and enthusiasm Workshop advances arsenic research and prevention A visit from the Dalai Lama — not an ordinary science talk Spirit Lecture features UNC Chancellor Carol Folt NIH celebrates equity, diversity, and inclusion Roundtable explores benefits and challenges of data sharing Seminar explores communication of uncertainty and risk Scientists inaugurate inflammation faculty Regional symposium addresses reproductive biology Trainees shine at reproductive biology symposium UNC Superfund scientists study effects of Dan River coal ash spill Building global partners...
Source: Environmental Factor - NIEHS Newsletter - April 1, 2014 Category: Environmental Health Source Type: news