NIH Establishes Early Version of Personalized Medicine Platform.
Authors: Barlas S Abstract Will "All of Us" provide clues on the origins of various illnesses? Congress hopes that analyzing the medical and biological data of millions of people will boost precision medicine and help predict outcomes. PMID: 31258306 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Accidental IV Infusion of Heparinized Irrigation in the Operating Room.
Authors: Grissinger M Abstract Accidental IV administration of heparinized irrigation solution occurs frequently. Two cases from ISMP Canada offer some safe practice recommendations. PMID: 31258307 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31258308 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Choy M Abstract Mavenclad (cladribine) tablets for relapsing MS forms; Duaklir Pressair (aclidinium bromide/formoterol fumarate) inhalant for COPD; Evenity (romosozumab-aqqg) injection for osteoporosis. PMID: 31258309 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Shingrix: A New Herpes Zoster Vaccine.
Authors: Maltz F, Fidler B Abstract Shingrix, a new vaccine for herpes zoster. PMID: 31258310 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Beyond Medical Cannabis: Considerations for Updates to Hospital Policies and Procedures.
Authors: O'Donnell J, Vogenberg FR, Vogenberg FR Abstract As marijuana legalization and use expands across the U.S., health care systems are struggling to keep abreast of the changes and trends in regulations. Considering marijuana's federal illegality and other restrictions on its use, the limited evidence for its clinical efficacy, and the myriad psychological adverse events, caution is recommended when establishing policies and procedures regarding coverage of marijuana and CBD products. PMID: 31258311 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Alpha-1 Antitrypsin Replacement in Patients With COPD.
Authors: Wells AD, Woods A, Hilleman DE, Malesker MA Abstract Chronic obstructive pulmonary disease can be attributed to genetic conditions and predispositions, among other factors. Alpha-1 antitrypsin deficiency (AATD) is a significant risk factor for COPD development and progression, and aggressive screening for all patients with COPD or adult-onset asthma is encouraged. PMID: 31258312 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Amiodarone-Induced Syndrome of Inappropriate Antidiuretic Hormone: A Case Report and Review of the Literature.
We report on such a case in which a patient was found to be hyponatremic after evaluation. An 88-year-old male who presented to the emergency department was found to be hyponatremic secondary to amiodarone-induced SIADH following a fall, with possible seizure and traumatic brain injury. He had a history of hypertension, paroxysmal atrial fibrillation, emphysema, myocardial infarction, benign prostatic hyperplasia, chronic kidney disease, Meniere's disease, anemia, and gastroesophageal reflux. Upon admission, his urine sodium level was elevated, and his serum sodium, urine osmolality, and anion gap were below normal. In the...
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evidence-Based Policy in Practice: Management of Carcinoid Syndrome Diarrhea.
Authors: Cook R, Hendifar AE Abstract Carcinoid syndrome causes substantial morbidity and reduces quality of life and survival. In a recent clinical trial, 97% of patients reported bowel movement-related issues, abdominal pain, flushing, and low energy. Combining somatostatin analogs with elotristat ethyl provides a new option for managing refractory CS symptoms. Health care providers should consider strategies that take advantage of approved dosing for patients with CS-related diarrhea. PMID: 31258314 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Digestive Disease Week 2019.
Authors: Otrompke J Abstract We review selected sessions on the questionable benefits of fecal microbiota transplant; intrahepatic cholestasis of pregnancy; weight-loss drugs in combination with intragastric balloon endoscopy; and beta blockers in pancreatic cancer. PMID: 31258315 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Osteoporosis Treatment-What We Don't Know.
Authors: PMID: 31258316 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Vitamin K May Be A-OK, in Kids and Cholestatic Patients.
Authors: Jannone G, van Dievoet MA, Coppin L, Sokal E, Stephenne X PMID: 31160862 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Article on Hospital Consolidation Misleads.
Authors: Hatton M PMID: 31160863 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Understanding Human Over-Reliance On Technology.
Authors: Grissinger M Abstract Implementing IT in medication-use systems reduces adverse drug events by decreasing human error. But over-reliance on technology can lead to automation bias and complacency. PMID: 31160864 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

A Drug Pricing "Transparency" Bill With Strong Bipartisan Support But Would It Accomplish Much?
A Drug Pricing "Transparency" Bill With Strong Bipartisan Support But Would It Accomplish Much? P T. 2019 Jun;44(6):323 Authors: Barlas S Abstract Several drug-price "remedy" bills are floating around Congress, with most being described as a "first step." So why is no one referring to that step as significant? PMID: 31160865 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31160866 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Kaufman MB Abstract Sunosi (solriamfetol) tablets for excessive daytime sleepiness with narcolepsy or obstructive sleep apnea; Zulresso (brexanolone) injection for postpartum depression in adults; Mayzent (siponimod) tablets for adults with relapsing forms of MS. PMID: 31160867 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant.
Authors: Bahr R, Lopez A, Rey JA Abstract Intranasal esketamine for treatment-resistant depression. PMID: 31160868 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

HHS Proposes Steps Toward Health Data Interoperability CMS and ONC Proposals Would Implement Cures Act.
Authors: Barlas S Abstract Since the introduction of the 2009 HITECH Act, how has system-wide data sharing fared among hospitals and physician offices? Not that well, according to the CMS. But will the new proposed rules improve things for providers, system developers, and patients? PMID: 31160869 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Using Information on Patient Adherence to Antipsychotic Medication to Understand Their Adherence to Other Medications.
Authors: Shafrin J, Silverstein AR, MacEwan JP, Lakdawalla DN, Hatch A, Forma FM Abstract Purpose: To assess how patient adherence to atypical antipsychotic medications is associated with adherence to concurrently used medications that treat other serious mental illnesses (SMIs), type-2 diabetes, or hypertension. Methods: Among patients who had been diagnosed with an SMI (i.e., bipolar disorder, major depressive disorder, or schizophrenia) in the previous year, we used health-insurance claims data to measure adherence based on medication fills. Patients diagnosed with an SMI were required to have 1) a prescript...
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Intravenous Versus Oral Acetaminophen in Ambulatory Surgical Center Laparoscopic Cholecystectomies: A Retrospective Analysis.
Conclusion: Single-dose PO APAP is non-inferior to IV APAP for postoperative analgesia in ASC laparoscopic cholecystectomy patients. The value of single-dose IV APAP in this population should be further explored. PMID: 31160871 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evaluation of Warfarin Patients with Low Time in Therapeutic Range (TTR) for Transition to Non-Vitamin-K Oral Anticoagulant (NOAC) Therapy.
Authors: Fovel LM, Miller CD, Seabury RW, Probst LA, Horvath L PMID: 31160872 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

European Association for the Study of the Liver The International Liver Congress 2019.
Authors: Alexander W Abstract We cover key sessions on hepatitis B, C, and D virus infections, hepatocellular carcinoma, nonalcoholic steatohepatitis, acute hepatic porphyria, and liver growth in polycystic kidney disease. PMID: 31160873 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 31160874 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Is an Indication-Based Prescribing System in Our Future?
Authors: Grissinger M Abstract Indication-based prescribing has many potential benefits, including preventing errors by reducing medication choices and assisting with medication reconciliation. PMID: 31080329 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

FTC Gives Generics Victory On "Pay for Delay": Reverse Payments Crimped, Patent Thickets Untouched.
FTC Gives Generics Victory On "Pay for Delay": Reverse Payments Crimped, Patent Thickets Untouched. P T. 2019 May;44(5):234-266 Authors: Barlas S Abstract How easy is it for generics to enter the market? It could be easier with legislation that opens up the field for generic competitors, but it is unlikely that such a bill will ever be introduced. PMID: 31080330 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31080331 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Kaufman MB Abstract Cablivi (caplacizumab-yhdp) for acquired thrombotic thrombocytopenic purpura; Egaten (triclabendazole) for fascioliasis; and Spravato (esketamine) for treatment-resistant depression. PMID: 31080332 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Treatment of Seizures Associated with Lennox-Gastaut and Dravet Syndromes: A Focus on Cannabidiol Oral Solution.
Authors: Lazaridis D, Eraikhuemen N, Williams K, Lovince J Abstract Cannabidiol oral solution for seizures associated with Lennox-Gastaut and Dravet syndromes. PMID: 31080333 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Are Hospital Prices a Bigger Problem than Drug Prices?: Congress Doesn't Know, Doesn't Care.
Authors: Barlas S Abstract What lies behind the growth of rising hospital prices? Many factors-including the impact of hospital mergers and the industry's complicated relationship with Congress. PMID: 31080334 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Virtual Reality in Pharmacy: Opportunities for Clinical, Research, and Educational Applications.
This article discusses the potential for the use of VR in pharmacy for clinical, research, and educational applications. PMID: 31080335 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

American College of Cardiology 68th Scientific Session and Exposition.
We report on two sessions on atrial fibrillation, two on heart failure, two on hypertension, and one each on endocarditis and ST-elevation myocardial infarction. PMID: 31080336 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Reframing Alzheimer's Disease: Guided by a New Research Framework, the Field is Poised For Greater Precision and Promising Horizons.
Authors: Worley SL Abstract This in-depth article on the sixth leading cause of death in the U.S. reports on the optimism of cutting-edge leaders in Alzheimer's disease research. The author examines key considerations such as the status of biomarker tests, and the search for new biomarkers; securing an accurate definition of the disease; risk factors; clinical trials and non-pharmacological studies. PMID: 31080337 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Regulatory and Legislative Disparities With Cannabis Present Challenges to P & T Committees and Health Care Providers.
Regulatory and Legislative Disparities With Cannabis Present Challenges to P&T Committees and Health Care Providers. P T. 2019 May;44(5):290-293 Authors: Marcoux R, Holmes L, Vogenberg FR, Pharm B Abstract Increased cannabis use has brought about a sea change in policy and attitudes toward regulation, and a multitude of rules that vary widely between states. The disparity has stymied any effective response to the problems surrounding access to cannabis products for those in need. Health care providers and practitioners, as well as P&T committees, must carefully undertake decisions on rational d...
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 31080339 [PubMed] (Source: P and T)
Source: P and T - May 15, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Trump Administration Announces Long-Awaited Rebate Changes: One Safe Harbor Eliminated, Two Others Created.
Authors: Barlas S Abstract The current rebate "safe harbor" encourages drug manufacturers to inflate list prices. The HHS's newly proposed rule threatens to eliminate this safe harbor but offers two new ones instead. PMID: 30930598 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

"Use as Directed" Can Cause Confusion for Both Patients and Practitioners.
"Use as Directed" Can Cause Confusion for Both Patients and Practitioners. P T. 2019 Apr;44(4):168-169 Authors: Grissinger M Abstract The familiar but ambiguous sigs on prescriptions are often of limited help to patients and pharmacists. Sometimes, the instruction to "use as directed" has resulted in serious errors. PMID: 30930599 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 30930600 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Kaufman MB Abstract Motegrity (prucalopride) for chronic idiopathic constipation; Aemcolo (rifamycin) for travelers' diarrhea; and Dextenza (dexamethasone ophthalmic insert) for ocular pain after ophthalmic surgery. PMID: 30930601 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Democratic Takeover of House Sparks Drug-Price Legislation Talks: But Strong Legislation Unlikely Given Patient and Industry Opposition.
Authors: Barlas S Abstract HHS has proposed regulations to attack high drug prices, a priority for the current administration. Both parties have spoken out against the drug companies but the change in control of the House is no guarantee of pricing legislation moving forward. And if drug manufacturers, PBMs, and others are adamant about tackling drug prices, why do they oppose the best cost-cutting proposals? PMID: 30930602 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Impact of a Comprehensive COPD Therapeutic Interchange Program on 30-Day Readmission Rates in Hospitalized Patients.
This study was a multi-center, retrospective, electronic chart review of patients with a diagnosis of COPD admitted to two hospitals from July 1, 2016 to June 30, 2017. Our intervention group was admitted to a 550-bed tertiary care hospital and was managed with a pharmacist-led CTIP for inhaled products used in COPD. Our control group was admitted to a 545-bed tertiary care hospital, which did not have a CTIP in place. Results: 2,885 hospitalized patients with a diagnosis of COPD were included in the analysis (1,350 in the intervention group and 1,535 in the control group). Univariable analysis demonstrated that the in...
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

A Guide to Bacterial Culture Identification And Results Interpretation.
Conclusion: This guide can assist pharmacists in their role as integral members of the antimicrobial stewardship team in an effort to improve patient care. PMID: 30930604 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

American Society of Clinical Oncology Genitourinary Symposium and Integrative Healthcare Symposium.
Authors: Alexander W Abstract From ASCO, we report on metastatic castrate-resistant prostate cancer and locally advanced/metastatic renal cell carcinoma. From IHS, we report on complementary and alternative medicine use by patients and practitioners, the effects of biological hemp-derived cannabidiol on PTSD in military veterans, and more. PMID: 30930605 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 30930606 [PubMed] (Source: P and T)
Source: P and T - April 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Paralyzed by Mistakes - Reassess the Safety of Neuromuscular Blockers in Your Facility.
Authors: Grissinger M Abstract Neuromuscular blockers have been inadvertently administered to patients who were not receiving proper ventilatory assistance, causing death or permanent injuries. PMID: 30828226 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Do GPOs Play a Role in Drug Shortages? Long-Standing Allegations Disputed by The GPOs.
Authors: Barlas S Abstract What role, if any, do group purchasing organizations play in drug shortages? PMID: 30828227 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 30828228 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Kaufman MB Abstract Inbrija (levodopa inhalation powder) for oral inhalation for the treatment of "off" episodes in Parkinson's disease; Ultomiris (ravulizumab) injection for treating adults with paroxysmal nocturnal hemoglobinuria; and Yupelri (revefenacin) inhalation solution for the maintenance treatment of patients with COPD. PMID: 30828229 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Meropenem-Vaborbactam (Vabomere ™): Another Option for Carbapenem-Resistant Enterobacteriaceae.
Meropenem-Vaborbactam (Vabomere™): Another Option for Carbapenem-Resistant Enterobacteriaceae. P T. 2019 Mar;44(3):110-113 Authors: Lee Y, Kim J, Trinh S Abstract Meropenem-Vaborbactam (Vabomere) for carbapenem-resistant Enterobacteriaceae. PMID: 30828230 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Forensic Analysis in Drug Litigation Finds Most Errors Occur with Commonly Used Therapies and Practices.
Authors: O'Donnell JT, O'Donnell JJ, Vogenberg FR Abstract In the complex setting of obstetrics and reproductive medicine, the medication-related injuries leading to the most litigation involve some of the most commonly used drugs, rather than the newer, more complicated therapies. The authors present a number of cases illustrating how sophisticated treatment of high-risk pregnancies can be jeopardized by a simple negligent act. PMID: 30828231 [PubMed] (Source: P and T)
Source: P and T - March 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research