Hardwiring Safety Into the Computer System: One Hospital's Actions to Provide Technology Support for U-500 Insulin.
We present technology enhancements that support the safe use of U-500 insulin. PMID: 31485140 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Bipartisan Drug-Patent Bills Ready for Senate Vote: Efforts Directed at Speeding Up Introduction of Generics.
Authors: Barlas S Abstract The legal tactics that drug manufacturers use to extend drug patents may be the biggest impediment to lowering drug prices and to Congress acting on pricing. Until now, that is. PMID: 31485141 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31485142 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Choy M Abstract Alpelisib (Piqray) for HR-positive/HER2-negative, PIK3CA-mutated, advanced/ metastatic breast cancer; polatuzumab vedotin-piiq (Polivy) for diffuse large B-cell lymphoma; and eculizumab (Soliris) for neuromyelitis optica spectrum disorder. PMID: 31485143 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Andexanet Alfa (Andexxa ®) for the Reversal of Direct Oral Anticoagulants.
Andexanet Alfa (Andexxa®) for the Reversal of Direct Oral Anticoagulants. P T. 2019 Sep;44(9):530-549 Authors: Momin JH, Candidate P, Hughes GJ Abstract Andexanet alfa (Andexxa®) for the reversal of direct oral anticoagulants. PMID: 31485144 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Andexanet Alfa: Preferred Treatment or Therapeutic Option?
Authors: Blow CA, Probst LA, Miller CD, Seabury RW PMID: 31485145 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evaluation of Warfarin Patients with Low Time in Therapeutic Range (TTR) for Transition to Non-Vitamin-K Oral Anticoagulant (NOAC) Therapy.
Authors: Fovel LM, Miller CD, Seabury RW, Probst LA, Horvath L PMID: 31485146 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Democratic Presidential Candidates Lead Attack on Drug Prices: Health Insurance Expansions Tougher on Drugs than Dems' Bill in House.
Authors: Barlas S Abstract House Democrats have been loudly proclaiming their intention to pass legislation that would rein in drug-price increases. But when it comes to actually passing significant bills, reality has not matched rhetoric. PMID: 31485147 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Antibiotic Breakpoints: How Redefining Susceptibility Preserves Efficacy and Improves Patient Care.
Authors: Redell M, Tillotson G Abstract Carbapenems are a primary treatment for infections from multidrug-resistant bacterial pathogens. To maintain their efficacy and control the emergence of further resistance, breakpoints that correspond to recommended doses with appropriate PK/PD target attainment are paramount. PMID: 31485148 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Bleeding and Elevated INR Secondary to Concomitant Tramadol and Warfarin Administration.
Authors: Veltri KT, Olsufka WA Abstract The exact mechanism of a tramadol-warfarin interaction has not been fully determined. The authors present a case study that illustrates the risks. PMID: 31485149 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Continuous Glucose Monitoring: A Review of Available Systems.
Authors: Funtanilla VD, Candidate P, Caliendo T, Hilas O Abstract Continuous glucose monitoring offers patients with diabetes a new option for monitoring their glucose levels on a regular basis, without the need for perpetual finger-sticks and myriad supplies. PMID: 31485150 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

The Impact of Self-Monitoring Blood Glucose Adherence On Glycemic Goal Attainment in an Indigent Population, With Pharmacy Assistance.
The objective of this study is to evaluate the utility of SMBG based on the impact of test-strip adherence on glycemic goal attainment in an indigent population that is provided with low-copay test strips. This retrospective cohort study included patients with T1DM or T2DM who were enrolled in PAP in 2016 and who received a prescription for test strips during the 90 days prior to hemoglobin A1c (HbA1c) measurement. Adherence was defined as the proportion of days covered (PDC)> 0.8. Of the 498 patients encountered, 20% of the adherent group (n = 245) and 25% of the nonadherent group (n = 253) had a goal of HbA1c
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 31485152 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Looking for Trouble: Identifying and Treating Hypotension.
Authors: PMID: 31485153 [PubMed] (Source: P and T)
Source: P and T - September 6, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

House Democrats Push Competing Drug Price Transparency Bills: May Provide Useful Data, But Not Downward Pressure on Prices.
Authors: Barlas S Abstract Congressional deliberations over several competing bills on drug-price transparency may generate some useful data but are unlikely to have any effect on prices. PMID: 31447529 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Chloral Hydrate: Is It Still Being Used? Are There Safer Alternatives?
Authors: Grissinger M Abstract Using chloral hydrate carries a risk of adverse events and compounding errors, and much of the available literature recommends using alternative sedatives for pediatric patients. But evidence regarding the efficacy of chloral hydrate and of alternative agents is conflicting. PMID: 31447530 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31447531 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

PerserisTM: A New and Long-Acting, Atypical Antipsychotic Drug-Delivery System.
Authors: Karas A, Burdge G, Rey JA Abstract Perseris: A new, long-acting, atypical antipsychotic drug-delivery system. PMID: 31447532 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

From Then Until Now: A Top-Down View Of The Affordable Care Act.
Authors: LaFontaine PR, Vogenberg FR, Pizzi LT Abstract How does the Patient Protection and Affordable Care Act (ACA) of 2010 differ from the act as it stands today? Many changes have occurred, in Medicaid expansion, private insurance coverage, the American Health Benefit Exchanges, and the individual mandate. PMID: 31447533 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evaluation of a Pharmacist-Driven Protocol to Reduce Inappropriate Use of Acid-Suppressive Medications In the Non-ICU Setting.
Authors: Mersfelder TL, Jacob C, Lam JK, Kavanaugh KJ, Molnar CM Abstract Purpose: Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2 blockers) continue to be over utilized for stress ulcer prophylaxis (SUP). Our study aims to evaluate the effectiveness and feasibility of a pharmacist-driven termination protocol in a community teaching hospital to limit the inappropriate use of acid-suppressive medications in the non-intensive care unit (ICU) setting. Methods: Patient charts were evaluated for the appropriate use of PPIs or H2 blockers. A centralized pharmacist contacted healthcare providers...
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Savings on High-Cost Drugs Such as Atypical Long-Acting Injectable Antipsychotics: Switching to Billing Under the Pharmacy Benefit in Outpatient Settings.
Conclusion: This study revealed a significant financial loss related to atypical LAI antipsychotics when the medical benefit model was utilized. By switching to billing under the pharmacy benefit, potential savings for high-cost drugs such as LAIs can be realized. PMID: 31447535 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Outcomes of Inpatient Administration of Restricted Antineoplastic Medications at a Large Academic Medical Institution.
Conclusion: In this single-center study, approximately one-third of the outpatient-restricted medications were not continued upon discharge. The findings suggest that our informal approval process could result in the suboptimal use of formulary outpatient-restricted medications for oncology and hematology indications. A more formalized request process might lead to the more effective utilization of these medications. PMID: 31447536 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

American Society of Clinical Oncology 2019.
Authors: Alexander W PMID: 31447537 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

"It Starts With One": Reflections on BIO 2019.
"It Starts With One": Reflections on BIO 2019. P T. 2019 Aug;44(8):491-493 Authors: Otrompke J PMID: 31447538 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Employer-Provider Interface Council (EPIC) 2019: Managing Health Benefits In The Era Of Change.
Authors: Segovia MN PMID: 31447539 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 31447540 [PubMed] (Source: P and T)
Source: P and T - August 27, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

NIH Establishes Early Version of Personalized Medicine Platform.
Authors: Barlas S Abstract Will "All of Us" provide clues on the origins of various illnesses? Congress hopes that analyzing the medical and biological data of millions of people will boost precision medicine and help predict outcomes. PMID: 31258306 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Accidental IV Infusion of Heparinized Irrigation in the Operating Room.
Authors: Grissinger M Abstract Accidental IV administration of heparinized irrigation solution occurs frequently. Two cases from ISMP Canada offer some safe practice recommendations. PMID: 31258307 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31258308 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Choy M Abstract Mavenclad (cladribine) tablets for relapsing MS forms; Duaklir Pressair (aclidinium bromide/formoterol fumarate) inhalant for COPD; Evenity (romosozumab-aqqg) injection for osteoporosis. PMID: 31258309 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Shingrix: A New Herpes Zoster Vaccine.
Authors: Maltz F, Fidler B Abstract Shingrix, a new vaccine for herpes zoster. PMID: 31258310 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Beyond Medical Cannabis: Considerations for Updates to Hospital Policies and Procedures.
Authors: O'Donnell J, Vogenberg FR, Vogenberg FR Abstract As marijuana legalization and use expands across the U.S., health care systems are struggling to keep abreast of the changes and trends in regulations. Considering marijuana's federal illegality and other restrictions on its use, the limited evidence for its clinical efficacy, and the myriad psychological adverse events, caution is recommended when establishing policies and procedures regarding coverage of marijuana and CBD products. PMID: 31258311 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Alpha-1 Antitrypsin Replacement in Patients With COPD.
Authors: Wells AD, Woods A, Hilleman DE, Malesker MA Abstract Chronic obstructive pulmonary disease can be attributed to genetic conditions and predispositions, among other factors. Alpha-1 antitrypsin deficiency (AATD) is a significant risk factor for COPD development and progression, and aggressive screening for all patients with COPD or adult-onset asthma is encouraged. PMID: 31258312 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Amiodarone-Induced Syndrome of Inappropriate Antidiuretic Hormone: A Case Report and Review of the Literature.
We report on such a case in which a patient was found to be hyponatremic after evaluation. An 88-year-old male who presented to the emergency department was found to be hyponatremic secondary to amiodarone-induced SIADH following a fall, with possible seizure and traumatic brain injury. He had a history of hypertension, paroxysmal atrial fibrillation, emphysema, myocardial infarction, benign prostatic hyperplasia, chronic kidney disease, Meniere's disease, anemia, and gastroesophageal reflux. Upon admission, his urine sodium level was elevated, and his serum sodium, urine osmolality, and anion gap were below normal. In the...
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evidence-Based Policy in Practice: Management of Carcinoid Syndrome Diarrhea.
Authors: Cook R, Hendifar AE Abstract Carcinoid syndrome causes substantial morbidity and reduces quality of life and survival. In a recent clinical trial, 97% of patients reported bowel movement-related issues, abdominal pain, flushing, and low energy. Combining somatostatin analogs with elotristat ethyl provides a new option for managing refractory CS symptoms. Health care providers should consider strategies that take advantage of approved dosing for patients with CS-related diarrhea. PMID: 31258314 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Digestive Disease Week 2019.
Authors: Otrompke J Abstract We review selected sessions on the questionable benefits of fecal microbiota transplant; intrahepatic cholestasis of pregnancy; weight-loss drugs in combination with intragastric balloon endoscopy; and beta blockers in pancreatic cancer. PMID: 31258315 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Osteoporosis Treatment-What We Don't Know.
Authors: PMID: 31258316 [PubMed] (Source: P and T)
Source: P and T - July 2, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Vitamin K May Be A-OK, in Kids and Cholestatic Patients.
Authors: Jannone G, van Dievoet MA, Coppin L, Sokal E, Stephenne X PMID: 31160862 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Article on Hospital Consolidation Misleads.
Authors: Hatton M PMID: 31160863 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Understanding Human Over-Reliance On Technology.
Authors: Grissinger M Abstract Implementing IT in medication-use systems reduces adverse drug events by decreasing human error. But over-reliance on technology can lead to automation bias and complacency. PMID: 31160864 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

A Drug Pricing "Transparency" Bill With Strong Bipartisan Support But Would It Accomplish Much?
A Drug Pricing "Transparency" Bill With Strong Bipartisan Support But Would It Accomplish Much? P T. 2019 Jun;44(6):323 Authors: Barlas S Abstract Several drug-price "remedy" bills are floating around Congress, with most being described as a "first step." So why is no one referring to that step as significant? PMID: 31160865 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Drug and Device News.
Authors: Abstract Approvals, new indications and formulations, and safety issues. PMID: 31160866 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Pharmaceutical Approval Update.
Authors: Kaufman MB Abstract Sunosi (solriamfetol) tablets for excessive daytime sleepiness with narcolepsy or obstructive sleep apnea; Zulresso (brexanolone) injection for postpartum depression in adults; Mayzent (siponimod) tablets for adults with relapsing forms of MS. PMID: 31160867 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant.
Authors: Bahr R, Lopez A, Rey JA Abstract Intranasal esketamine for treatment-resistant depression. PMID: 31160868 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

HHS Proposes Steps Toward Health Data Interoperability CMS and ONC Proposals Would Implement Cures Act.
Authors: Barlas S Abstract Since the introduction of the 2009 HITECH Act, how has system-wide data sharing fared among hospitals and physician offices? Not that well, according to the CMS. But will the new proposed rules improve things for providers, system developers, and patients? PMID: 31160869 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Using Information on Patient Adherence to Antipsychotic Medication to Understand Their Adherence to Other Medications.
Authors: Shafrin J, Silverstein AR, MacEwan JP, Lakdawalla DN, Hatch A, Forma FM Abstract Purpose: To assess how patient adherence to atypical antipsychotic medications is associated with adherence to concurrently used medications that treat other serious mental illnesses (SMIs), type-2 diabetes, or hypertension. Methods: Among patients who had been diagnosed with an SMI (i.e., bipolar disorder, major depressive disorder, or schizophrenia) in the previous year, we used health-insurance claims data to measure adherence based on medication fills. Patients diagnosed with an SMI were required to have 1) a prescript...
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Intravenous Versus Oral Acetaminophen in Ambulatory Surgical Center Laparoscopic Cholecystectomies: A Retrospective Analysis.
Conclusion: Single-dose PO APAP is non-inferior to IV APAP for postoperative analgesia in ASC laparoscopic cholecystectomy patients. The value of single-dose IV APAP in this population should be further explored. PMID: 31160871 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Evaluation of Warfarin Patients with Low Time in Therapeutic Range (TTR) for Transition to Non-Vitamin-K Oral Anticoagulant (NOAC) Therapy.
Authors: Fovel LM, Miller CD, Seabury RW, Probst LA, Horvath L PMID: 31160872 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

European Association for the Study of the Liver The International Liver Congress 2019.
Authors: Alexander W Abstract We cover key sessions on hepatitis B, C, and D virus infections, hepatocellular carcinoma, nonalcoholic steatohepatitis, acute hepatic porphyria, and liver growth in polycystic kidney disease. PMID: 31160873 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research

Research Briefs.
Authors: PMID: 31160874 [PubMed] (Source: P and T)
Source: P and T - June 5, 2019 Category: Drugs & Pharmacology Tags: P T Source Type: research