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Total 52 results found since Jan 2013.

58P Risk factors for immune related adverse events: A retrospective study
ConclusionThis study helped distinguish potential risk factors for irAE, like the female gender and history of allergies. Autoimmune disorders are already reported as risk factores. However the small sample isn't enough for us to draw accurate conclusions. More prospective trials are waranted in this setting.Legal entity responsible for the studyThe authors.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - December 15, 2019 Category: Cancer & Oncology Source Type: research

Characterization of outcomes in patients with advanced genitourinary malignancies treated with immune checkpoint inhibitors.
CONCLUSION: Greater frequency and higher grades of irAEs are associated with better treatment response in patients with RCC and urothelial malignancy receiving ICI therapy. The presence of liver metastases denotes a negative predictive marker for immunotherapy efficacy. SUMMARY: Immune checkpoint inhibitors (ICI) are increasingly used to treat genitourinary (GU) malignancies. However, clinical data regarding patients with advanced-stage GU malignancies treated with ICI is lacking. Thus, we performed a single-center, retrospective cohort study on patients with metastatic and unresectable renal cell carcinoma (RCC) and ...
Source: Urologic Oncology - January 22, 2021 Category: Urology & Nephrology Authors: Ma VT, Su CT, Hu M, Taylor JMG, Daignault-Newton S, Kellezi O, Dahl MN, Shah MA, Erickson S, Lora J, Hamasha R, Ali A, Yancey S, Kiros L, Balicki HM, Winfield DC, Green MD, Alva AS Tags: Urol Oncol Source Type: research

Adenocarcinoma of the Stomach and Neuroendocrine Carcinoma of the Colon in a 45-Year-Old Male Patient Suffering from Common Variable Immunodeficiency (CVID) and Ulcerative Colitis.
Abstract Common variable immunodeficiency (CVID) is the most common primary antibody deficient syndrome in adults. Among the broad spectrum of clinical manifestations are recurrent infections, allergies, autoimmune, tumour, pulmonary, liver and gastrointestinal diseases. Here we report the case of a 45-year-old male patient, who has been suffering from ulcerative colitis - likewise recognised as a CVID-associated disease - for many years. He was admitted to our clinic with a rapid progressive reduction of his general condition and a loss of weight. Diagnostic work-up revealed adenocarcinoma of the stomach as well ...
Source: Zeitschrift fur Gastroenterologie - December 1, 2012 Category: Gastroenterology Authors: Gemeinhardt M, Türck J, Piper B, Helmberger T, Nerlich A, Schepp W Tags: Z Gastroenterol Source Type: research

Clinical Translation of an Albumin-Binding PET Radiotracer 68Ga-NEB
Conclusion: As a blood-pool imaging agent, 68Ga-NEB is safe to use in the clinic, and our preliminary studies demonstrate the value of differentiating hepatic hemangioma from other benign or malignant focal hepatic lesions. Easy labeling with different positron emitters of various half-lives, excellent pharmacokinetics, and imaging quality warrant further clinical applications of NEB-based PET tracers.
Source: Journal of Nuclear Medicine - October 1, 2015 Category: Nuclear Medicine Authors: Zhang, J., Lang, L., Zhu, Z., Li, F., Niu, G., Chen, X. Tags: Basic Science Investigations Source Type: research

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research

Role of diffusion weighted imaging (DWI) for hepatocellular carcinoma (HCC) detection and its grading on 3T MRI: A prospective study
Conclusion DWI can be used as an alternative for the detection and characterization of HCC, especially in patients with impaired renal function or contrast allergies precluding the use of contrast. In addition, DWI with ADC measurement may be helpful for non-invasive and preoperative prediction of the degree of differentiation of HCC.
Source: Journal of Clinical and Experimental Hepatology - September 1, 2016 Category: Gastroenterology Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Anticancer effects of Poncirus  fructus on hepatocellular carcinoma through regulation of apoptosis, migration, and invasion.
This study investigated the ability of PF to induce apoptosis and inhibit the invasiveness and migratory ability of HCC cell lines (Hep3B and Huh7). Wound healing, Transwell migration and invasion, and colony‑formation assays, as well as flow cytometry, were used to analyze cell proliferation, migration, invasion, and apoptosis. Epithelial‑mesenchymal transition (EMT)‑related and apoptotic proteins were assessed by western blotting. The mitochondrial membrane potential of the Hep3B and Huh7 cells was observed with tetramethylrhodamine ethyl ester. The reactive oxygen species (ROS) level was determined by dihydroethid...
Source: Oncology Reports - November 1, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

CCL24 Signaling in the Tumor Microenvironment
Adv Exp Med Biol. 2021;1302:91-98. doi: 10.1007/978-3-030-62658-7_7.ABSTRACTChemokines with their network play an important role in cancer growth, metastasis, and host-tumor interactions. Of many chemokines, C-C motif chemokine ligand 24 (CCL24) has been shown to contribute to tumorigenesis as well as inflammatory diseases like asthma, allergies, and eosinophilic esophagitis. CCL24 is expressed in some tumor cells such as colon cancer, hepatocellular carcinoma, and cutaneous T cell lymphoma. CCL24 can be used as a potential biomarker in several cancers including colon cancer, non-small cell cancer, and nasopharyngeal carci...
Source: Advances in Experimental Medicine and Biology - July 21, 2021 Category: Research Authors: Sung-Jig Lim Source Type: research

Loco-regional treatment of hepatocellular carcinoma: Role of contrast-enhanced ultrasonography
World J Hepatol. 2022 May 27;14(5):911-922. doi: 10.4254/wjh.v14.i5.911. Epub 2022 Apr 7.ABSTRACTHepatocellular carcinoma (HCC) is one of the few cancers for which locoregional treatments (LRTs) are included in international guidelines and are considered as a valid alternative to conventional surgery. According to Barcelona Clinic Liver Cancer classification, percutaneous treatments such as percutaneous ethanol injection, radiofrequency ablation and microwave ablation are the therapy of choice among curative treatments in patients categorized as very early and early stage, while transcatheter arterial chemoembolization is ...
Source: World Journal of Hepatology - June 20, 2022 Category: Gastroenterology Authors: Agostino Inzerillo Maria Franca Meloni Adele Taibbi Tommaso Vincenzo Bartolotta Source Type: research