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Nutrition: Diets
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Assembling the anaerobic gamma-butyrobetaine to TMA metabolic pathway in < em > Escherichia fergusonii < /em > and confirming its role in TMA production from dietary < em > L- < /em > carnitine in murine models
mBio. 2023 Sep 22:e0093723. doi: 10.1128/mbio.00937-23. Online ahead of print.ABSTRACTTrimethylamine-N-oxide (TMAO) is a major pro-atherogenic and pro-thrombotic metaorganismal molecule produced through the initial conversion of the dietary L-carnitine and other precursors into trimethylamine (TMA). We recently identified a dual-microbe anaerobic pathway for the metabolism of L-carnitine into TMA, in which the widely distributed cai operon in Enterobacteriaceae converts L-carnitine into gamma-butyrobetaine (γBB), followed by the degradation of γBB into TMA by the relatively rare gamma-butyrobetaine utilization (gbu) gene...
Source: Atherosclerosis - September 22, 2023 Category: Cardiology Authors: Mohammed Dwidar Jennifer A Buffa Zeneng Wang Akeem Santos Aaron N Tittle Xiaoming Fu Adeline M Hajjar Joseph A DiDonato Stanley L Hazen Source Type: research
Untargeted serum metabolomic profiles and breast density in young women
CONCLUSION: Our results suggest an inverse association of branched chain amino acids with %DBV. Larger studies in diverse populations are needed.PMID:37737303 | DOI:10.1007/s10552-023-01793-w
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seungyoun Jung Sarah Silva Cher M Dallal Erin LeBlanc Kenneth Paris John Shepherd Linda G Snetselaar Linda Van Horn Yuji Zhang Joanne F Dorgan Source Type: research
Association between weight loss agents and elevated liver enzymes: a population-based cross-sectional study
This study aimed to investigate the associations between weight loss agents and elevated liver enzymes at the population-level. We conducted a cross-sectional study using Korea National Health and Nutrition Examination Survey (KNHANES) data from 2013 to 2019. This study included 36,259 participants over 20 years of age who completed the questionnaire and had no history of hepatitis, cancer, or renal failure. In these participants, we analyzed associations between weight loss agents and elevated liver enzymes by constructing multiple logistic regression models with adjustment for confounding factors and stratified by sex, a...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Ye-Jee Kim Seo Young Kang Mi-Sook Kim Joongyub Lee Bo Ram Yang Source Type: research
Health equity in action: using community-engaged research to update an intervention promoting a healthy home food environment to Black/African American families
CONCLUSION: The Delphi Technique shows promise as a method for conducting community-engaged research that promotes engagement and identifies key information needed to adapt and implement an existing intervention in a community setting.PMID:37736870 | DOI:10.1007/s10552-023-01753-4
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Debbe Thompson Chishinga Callender Jayna M Dave Maria L Jibaja-Weiss Jane R Montealegre Source Type: research
Role of Mediterranean diet in the development and recurrence of meningiomas: a narrative review
This study aims to provide an overview about the relationship between meningiomas and food assumption in the Mediterranean diet and whether it can be useful in meningioma prevention or it, somehow, can prevent their recurrence. The authors performed a wide literature search in PubMed and Scopus databases investigating the presence of a correlation between Mediterranean diet and meningiomas. The following MeSH and free text terms were used: “Meningiomas” AND “Diet” and “Brain tumors” AND “diet.” Databases’ search yielded a total of 749 articles. After duplicate removal, an abstract screening according to t...
Source: Neurosurgical Review - September 22, 2023 Category: Neurosurgery Source Type: research
Compliance with public health recommendations of cancer-free female research volunteers: the French Seintinelles study
CONCLUSIONS: This study allowed to identify the need to increase the level of knowledge on modifiable risk factors for cancer among the general population and to better clarify the content of prevention messages.PMID:37733136 | DOI:10.1007/s10552-023-01788-7
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Alexandra-Cristina Paunescu Cyrille Delpierre Guillemette Jacob Lidia Delrieu Myriam Pannard Marie Pr éau Marina Kvaskoff Source Type: research
Household cooking fuel and gallbladder cancer risk: a multi-centre case-control study in India
CONCLUSION: Biomass burning was associated with a high-risk for GBC and should be considered as a modifiable risk factor for GBC. Clean cooking fuel can potentially mitigate, and a healthy diet can partially reduce the risk among women.PMID:37733135 | DOI:10.1007/s10552-023-01787-8
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Krithiga Shridhar Manigreeva Krishnatreya Ranjit Kumar Dimple Kondal Mouchumee Bhattacharyya Banti Kalita Prakriti Snehil Amulya K Singh Amal Chandra Kataki Ashok Ghosh None D Prabhakaran Poornima Prabhakaran Preet K Dhillon Source Type: research
Alpha-lipoic acid, apocynin or probiotics influence glutathione status and selected inflammatory parameters in C57/BL6 mice when combined with a low-fat diet
CONCLUSIONS: Supplementation of the tested compounds with LFD appears to have a positive influence on the glutathione redox status of pulmonary tissues and selected inflammatory parameters in mouse blood.PMID:37730940 | DOI:10.1007/s43440-023-00527-8
Source: Pharmacological Reports - September 21, 2023 Category: Drugs & Pharmacology Authors: Paulina Kleniewska Rafa ł Pawliczak Source Type: research
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Very early onset perinatal constipation: Can it be cow's milk protein allergy?
World J Gastroenterol. 2023 Sep 7;29(33):4920-4926. doi: 10.3748/wjg.v29.i33.4920.ABSTRACTDelayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung's disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow's milk protein allergy (CMPA) is often diagnosed in infa...
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Rajalakshmy Arakoni Hebat Kamal Sam Xianjun Cheng Source Type: research
Diabetes exacerbates inflammatory bowel disease in mice with diet-induced obesity
CONCLUSION: In obese mice, diabetes worsened clinical and pathologic outcomes of colitis via mechanisms that are reversible with treatment of hyperglycemia. Hyperglycemia-induced intestinal barrier dysfunction offers a plausible mechanism linking diabetes to increased colitis severity. These findings suggest that effective diabetes management may decrease the clinical severity of IBD.PMID:37731997 | PMC:PMC10507503 | DOI:10.3748/wjg.v29.i33.4991
Source: World Journal of Gastroenterology : WJG - September 21, 2023 Category: Gastroenterology Authors: Kendra L Francis Kimberly M Alonge Maria Cristina Pacheco Shannon J Hu Cody A Krutzsch Gregory J Morton Michael W Schwartz Jarrad M Scarlett Source Type: research
Relationships of pregnancy and postpartum diet quality with offspring birth weight and weight status through 12 months
CONCLUSIONS: Maternal diet quality during pregnancy (and during postpartum in mothers who breastfed for a longer duration) was inversely related to LGA and weight status indicators from birth through 12 months. Increasing maternal diet quality may have use for promoting healthy infant weight development.PMID:37731285 | DOI:10.1002/oby.23891
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Leah Lipsky Jenna Cummings Anna Maria Siega-Riz Tonja Nansel Source Type: research
Weight-independent effects of Roux-en-Y gastric bypass surgery on remission of nonalcoholic fatty liver disease in mice
CONCLUSIONS: RYGB improved whole-body composition and hepatic lipid homeostasis to a greater extent than CR in mice. RYGB was associated with discrete remodeling of the hepatic transcriptome, suggesting that surgery may be mechanistically additive to CR.PMID:37731222 | DOI:10.1002/oby.23876
Source: Obesity - September 21, 2023 Category: Eating Disorders & Weight Management Authors: Christopher L Axelrod Ingeborg Langohr Wagner S Dantas Elizabeth C Heintz Bolormaa Vandanmagsar Shengping Yang Elizabeth R M Zunica R Leigh Townsend Vance L Albaugh Hans-Rudolf Berthoud John P Kirwan Source Type: research
Very early onset perinatal constipation: Can it be cow's milk protein allergy?
World J Gastroenterol. 2023 Sep 7;29(33):4920-4926. doi: 10.3748/wjg.v29.i33.4920.ABSTRACTDelayed passage of meconium or constipation during the perinatal period is traditionally regarded as a signal to initiate further work up to evaluate for serious diagnoses such as Hirschsprung's disease (HD), meconium ileus due to Cystic Fibrosis, etc. The diagnosis of HD particularly warrants invasive testing to confirm the diagnosis, such as anorectal manometry or rectal suction biopsy. What if there was another etiology of perinatal constipation, that is far lesser known? Cow's milk protein allergy (CMPA) is often diagnosed in infa...
Source: World Journal of Gastroenterology - September 21, 2023 Category: Gastroenterology Authors: Rajalakshmy Arakoni Hebat Kamal Sam Xianjun Cheng Source Type: research
