ECI biocommentary: Shiraz Badurdeen
Pediatr Res. 2024 Apr 24. doi: 10.1038/s41390-024-03218-z. Online ahead of print.NO ABSTRACTPMID:38658661 | DOI:10.1038/s41390-024-03218-z (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Shiraz Badurdeen Source Type: research
Hirschsprung's disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3 β
CONCLUSION: VIRMA can inhibit cell migration and proliferation by upregulating the expression of GSK3β, contributing to the onset of HSCR.IMPACT: The expressions of VIRMA were significantly reduced in HSCR, while GSK3β expression was increased in HSCR, and can be used as a molecular marker. VIRMA overexpression promoted the proliferation and migration of SH-SY5Y and HEK-293T cells. VIRMA can inhibit the degradation of GSK3β mRNA and increase the expression of GSK3β.PMID:38658662 | DOI:10.1038/s41390-024-03136-0 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Yang Yang Mengzhen Zhang Nan Li Chen Wang Huirong Yang Xinwei Hou Jiaming Yang Kaisi Fan Liucheng Yang Kai Wu Source Type: research
Young hearts, early risks: novel cardiovascular biomarkers in former very preterm infants at kindergarten age
CONCLUSION: In preterm-born children, iFGF-23 and secretoneurin both offer prospects as valuable cardiovascular biomarkers, potentially allowing for risk stratification and timely implementation of preventive measures.IMPACT: Former very preterm infants have increased plasma concentrations of the novel cardiovascular biomarkers intact fibroblast growth factor-23 (iFGF-23) and secretoneurin at kindergarten age. Increases in iFGF-23 concentrations are associated with decreased distensibility of the descending aorta even at this early age. Monitoring of cardiovascular risk factors is essential in individuals with a history of...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Wolfgang Mitterer Irena Odri Komazec Eva Huber Benedikt Schaefer Anna Posod Ursula Kiechl-Kohlendorfer Source Type: research
GFRA4 improves the neurogenic potential of enteric neural crest stem cells via hedgehog pathway
CONCLUSION: GFRA4 promotes proliferation and differentiation but inhibits apoptosis of ENCSCs via the hedgehog pathway in HSCR.IMPACT: This study confirms that GFRA4 improves the proliferation and differentiation of ENCSCs via modulation of the hedgehog pathway. This study for the first time revealed the role and the mechanism of the action of GFRA4 in HSCR, which indicates that GFRA4 may play a role in the pathological development of HSCR. Our findings may lay the foundation for further investigation of the mechanisms underlying HSCR development and into targets of HSCR treatment.PMID:38658664 | DOI:10.1038/s41390-024-031...
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Fangfang Zhang Mingyu Cui Lijuan Zhang Bangzhen Ma Feng Guo Gang Wang Source Type: research
Is choline deficiency an unrecognized factor in necrotizing enterocolitis of preterm infants?
In conclusion, this review supports the need for randomized clinical trials to test the hypothesis that additional choline or PC provided parenterally or enterally can reduce the incidence of NEC in preterm infants. IMPACT STATEMENT: Low choline status in preterm infants who are managed by conventional nutrition is plausibly linked to the risk of developing necrotizing enterocolitis.PMID:38658665 | DOI:10.1038/s41390-024-03212-5 (Source: Pediatric Research)
Source: Pediatric Research - April 24, 2024 Category: Pediatrics Authors: Douglas C Drenckpohl Danielle N Christifano Susan E Carlson Source Type: research
Early career investigator biocommentary: Lauren Erdman
Pediatr Res. 2024 Apr 23. doi: 10.1038/s41390-024-03216-1. Online ahead of print.NO ABSTRACTPMID:38654094 | DOI:10.1038/s41390-024-03216-1 (Source: Pediatric Research)
Source: Pediatric Research - April 23, 2024 Category: Pediatrics Authors: Lauren Erdman Source Type: research
Early career investigator biocommentary: Lauren Erdman
Pediatr Res. 2024 Apr 23. doi: 10.1038/s41390-024-03216-1. Online ahead of print.NO ABSTRACTPMID:38654094 | DOI:10.1038/s41390-024-03216-1 (Source: Pediatric Research)
Source: Pediatric Research - April 23, 2024 Category: Pediatrics Authors: Lauren Erdman Source Type: research
Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty
CONCLUSIONS: The obesity risk gene polymorphisms MC4R rs571312 and rs12970134 were associated with precocious puberty in Chinese girls with obesity, and girls with risk genotypes and high socioeconomic status should be given extra attention.IMPACT: This is the first study that identified the association between rs571312 and rs12970134 of MC4R gene and precocious puberty in Chinese children. We found that when girls were in the high socioeconomic status, the risk genotypes of rs571312 and rs12970134 had a greater effect on precocious puberty. The results of this study have great public health implications. It is recommended...
Source: Pediatric Research - April 22, 2024 Category: Pediatrics Authors: Peng Xue Jianfei Lin Jingyi Tang Yao Chen Tingting Yu Chang Chen Huijun Kong Cuilan Lin Shijian Liu Source Type: research
Commentary on the challenges of modeling hepatoblastoma in-vivo
Pediatr Res. 2024 Apr 22. doi: 10.1038/s41390-024-03215-2. Online ahead of print.NO ABSTRACTPMID:38649725 | DOI:10.1038/s41390-024-03215-2 (Source: Pediatric Research)
Source: Pediatric Research - April 22, 2024 Category: Pediatrics Authors: Edward H Hurley Source Type: research
Regional variability in therapeutic hypothermia eligibility criteria for neonatal hypoxic-ischemic encephalopathy
Pediatr Res. 2024 Apr 22. doi: 10.1038/s41390-024-03184-6. Online ahead of print.ABSTRACTEarly induced therapeutic hypothermia represents the cornerstone treatment in neonates with probable hypoxic-ischemic encephalopathy. The selection of patients for treatment usually involves meeting criteria indicating evidence of perinatal hypoxia-ischemia and the presence of moderate or severe encephalopathy. In this review, we highlight the variability that exists between some of the different regional and national eligibility guidelines. Determining the potential presence of perinatal hypoxia-ischemia may require either one, two or...
Source: Pediatric Research - April 22, 2024 Category: Pediatrics Authors: Jacopo Proietti Geraldine B Boylan Brian H Walsh Source Type: research
Caffeine: how early is too early?
Pediatr Res. 2024 Apr 20. doi: 10.1038/s41390-024-03199-z. Online ahead of print.NO ABSTRACTPMID:38643263 | DOI:10.1038/s41390-024-03199-z (Source: Pediatric Research)
Source: Pediatric Research - April 20, 2024 Category: Pediatrics Authors: Ryan Kilpatrick Jonathan M Davis Jacob V Aranda Source Type: research
Body composition and motor function in children born large for gestational age at term
CONCLUSIONS: In school-aged children who were born LGA, monitoring increased fat mass index and decreased gait deviation index could lessen the risk of metabolic syndrome and reduced gait function.IMPACT: Children aged 6-12 years who were born large for gestational age (LGA) at term showed a higher fat mass index and lower gait deviation index than those who were born appropriate for gestational age at term. No significant differences in balance function or muscle strength were observed between groups. On multiple regression analysis, gait deviation index was associated with being LGA at birth and fat mass index. In school...
Source: Pediatric Research - April 20, 2024 Category: Pediatrics Authors: Yuji Ito Tadashi Ito Sho Narahara Hideshi Sugiura Yuichiro Sugiyama Tetsuo Hattori Hiroyuki Kidokoro Takeshi Tsuji Tetsuo Kubota Jun Natsume Koji Noritake Nobuhiko Ochi Source Type: research
Finding pediatric thromboembolism: needles in a big data haystack
Pediatr Res. 2024 Apr 20. doi: 10.1038/s41390-024-03186-4. Online ahead of print.NO ABSTRACTPMID:38643265 | DOI:10.1038/s41390-024-03186-4 (Source: Pediatric Research)
Source: Pediatric Research - April 20, 2024 Category: Pediatrics Authors: Katrina Blankenhorn William Beau Mitchell Source Type: research
The predictive value of MRI scores for neurodevelopmental outcome in infants with neonatal encephalopathy
CONCLUSION: A more detailed scoring system had better predictive value for adverse outcome. GM injury graded on both scoring systems was an independent predictor of each outcome measure.IMPACT STATEMENTS: A more detailed MRI scoring system had a better predictive value for motor, cognitive and composite outcomes. While hypoxic-ischemic brain injuries in the deep grey matter and cerebellum were predictive of adverse outcome, white matter injury including cortical involvement was not associated with any of the outcome measures at 2 years of age. Structured MRI evaluation based on validated scores may aid future clinical rese...
Source: Pediatric Research - April 18, 2024 Category: Pediatrics Authors: Csilla Andorka Hajnalka Barta Timea Sesztak Nora Nyilas Kata Kovacs Ludovika Dunai Gabor Rudas Agnes Jermendy Miklos Szabo Eniko Szakmar Source Type: research
Sleep and internalizing problems in primary school children with attention-deficit hyperactivity disorder
CONCLUSION: For children with ADHD, when it is difficult to identify internalizing problems, especially emotional problems, we can take sleep and externalizing problems as clues to improve our clinical ability to recognize and deal with emotional problems.IMPACT: 1. We first explored the possible mediating role of conduct problems between sleep and emotional problems in primary school children with ADHD. 2. When it is difficult to identify internalizing problems, especially emotional problems, we can take sleep and externalizing problems as clues to improve our clinical ability to recognize emotional problems for children ...
Source: Pediatric Research - April 18, 2024 Category: Pediatrics Authors: Han-Yu Dong Chun-Yue Miao Yang Xue Yu Zhang Ling Shan Fei-Yong Jia Lin Du Source Type: research
