Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation
CONCLUSION: This in vitro study provides insight into the effect of skin color on TcB measurements: the TcB is underestimated as skin pigmentation increases and this effect becomes more pronounced at higher bilirubin levels. Our results highlight the need for improved TcB meter design and cautious interpretation of TcB readings on newborns with dark skin.IMPACT: Key message: Skin color influences transcutaneous bilirubin measurements: the darker the skin, the larger the underestimation. What this study adds to existing literature: Existing literature is inconclusive regarding the influence of skin color on transcutaneous b...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Alida J Dam-Vervloet Claudia F Morsink Marleen E Krommendijk Ingrid M Nijholt Henrica L M van Straaten Lieke Poot Nienke Bosschaart Source Type: research
Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis
CONCLUSION: Antenatal betamethasone stabilizes physiologic parameters in LPS treated lambs. Budesonide mixed with surfactant further decreases injury and improves respiratory physiology in betamethasone treated animals.IMPACT: Antenatal betamethasone improved lung and systemic physiology in the setting of intra-amniotic LPS. The addition of budesonide to the surfactant further improved lung function. Budesonide levels in the plasma and lung were lower in lambs exposed to either LPS or LPS and Betamethasone animals, and these findings were not explained by increased esterification in the lungs. The combination of antenatal ...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Noah H Hillman Matthew W Kemp Emily Royse Hayley Grzych Haruo Usada Hideyuki Ikeda Yuki Takahashi Tsukasa Takahashi Alan H Jobe Erin Fee Source Type: research
Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation
CONCLUSION: This in vitro study provides insight into the effect of skin color on TcB measurements: the TcB is underestimated as skin pigmentation increases and this effect becomes more pronounced at higher bilirubin levels. Our results highlight the need for improved TcB meter design and cautious interpretation of TcB readings on newborns with dark skin.IMPACT: Key message: Skin color influences transcutaneous bilirubin measurements: the darker the skin, the larger the underestimation. What this study adds to existing literature: Existing literature is inconclusive regarding the influence of skin color on transcutaneous b...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Alida J Dam-Vervloet Claudia F Morsink Marleen E Krommendijk Ingrid M Nijholt Henrica L M van Straaten Lieke Poot Nienke Bosschaart Source Type: research
Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis
CONCLUSION: Antenatal betamethasone stabilizes physiologic parameters in LPS treated lambs. Budesonide mixed with surfactant further decreases injury and improves respiratory physiology in betamethasone treated animals.IMPACT: Antenatal betamethasone improved lung and systemic physiology in the setting of intra-amniotic LPS. The addition of budesonide to the surfactant further improved lung function. Budesonide levels in the plasma and lung were lower in lambs exposed to either LPS or LPS and Betamethasone animals, and these findings were not explained by increased esterification in the lungs. The combination of antenatal ...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Noah H Hillman Matthew W Kemp Emily Royse Hayley Grzych Haruo Usada Hideyuki Ikeda Yuki Takahashi Tsukasa Takahashi Alan H Jobe Erin Fee Source Type: research
Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation
CONCLUSION: This in vitro study provides insight into the effect of skin color on TcB measurements: the TcB is underestimated as skin pigmentation increases and this effect becomes more pronounced at higher bilirubin levels. Our results highlight the need for improved TcB meter design and cautious interpretation of TcB readings on newborns with dark skin.IMPACT: Key message: Skin color influences transcutaneous bilirubin measurements: the darker the skin, the larger the underestimation. What this study adds to existing literature: Existing literature is inconclusive regarding the influence of skin color on transcutaneous b...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Alida J Dam-Vervloet Claudia F Morsink Marleen E Krommendijk Ingrid M Nijholt Henrica L M van Straaten Lieke Poot Nienke Bosschaart Source Type: research
Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis
CONCLUSION: Antenatal betamethasone stabilizes physiologic parameters in LPS treated lambs. Budesonide mixed with surfactant further decreases injury and improves respiratory physiology in betamethasone treated animals.IMPACT: Antenatal betamethasone improved lung and systemic physiology in the setting of intra-amniotic LPS. The addition of budesonide to the surfactant further improved lung function. Budesonide levels in the plasma and lung were lower in lambs exposed to either LPS or LPS and Betamethasone animals, and these findings were not explained by increased esterification in the lungs. The combination of antenatal ...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Noah H Hillman Matthew W Kemp Emily Royse Hayley Grzych Haruo Usada Hideyuki Ikeda Yuki Takahashi Tsukasa Takahashi Alan H Jobe Erin Fee Source Type: research
Falls in oxygen saturations accompany electrographic seizures in term neonates: an observational study
CONCLUSION: Acute decreases in SpO2 were seen in term neonates associated with seizures and these were not always accompanied by an apnoeic episode. Physiologic download in association with EEG monitoring may assist in improving seizure detection. Unexplained drops in SpO2 could indicate further investigation for possible seizures in at-risk neonates.IMPACT: A decrease in blood oxygen saturation (SpO2) associated with EEG seizures can occur in term infants with HIE or perinatal stroke. Drops in SpO2 associated with EEG seizures in term infants with HIE or stroke may occur in the absence of apnoeas. Unexplained acute falls ...
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: David Wertheim Anup C Kage Ivone Lancoma-Malcolm Caroline Francia Michael Yoong Divyen K Shah Source Type: research
Approaches to protocol standardization and data harmonization in the ECHO-wide cohort study
We describe the tools, systems, and approaches we employed to facilitate harmonized data for impactful analyses of child health outcomes.PMID:38365871 | DOI:10.1038/s41390-024-03039-0 (Source: Pediatric Research)
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: Lisa P Jacobson Corette B Parker David Cella Daniel K Mroczek Barry M Lester program collaborators for Environmental influences on Child Health Outcomes Source Type: research
Who is accountable for stopping racism in our children's hospitals?
Pediatr Res. 2024 Feb 16. doi: 10.1038/s41390-024-03089-4. Online ahead of print.NO ABSTRACTPMID:38365872 | DOI:10.1038/s41390-024-03089-4 (Source: Pediatric Research)
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: Michael DeBaun Source Type: research
Congenital anomalies and predisposition to severe COVID-19 among pediatric patients in the United States
CONCLUSIONS AND RELEVANCE: Congenital anomalies are associated with greater odds of experiencing severe symptoms of COVID-19. In addition to congenital heart defects, all other birth defects may increase the odds for more severe COVID-19.IMPACT: All congenital anomalies are associated with increased odds of severe COVID-19. This study is the largest and among the first to investigate birth defects across all body systems. The multicenter large data and analysis demonstrate the increased odds of severe COVID19 in pediatric patients with congenital anomalies affecting any body system. These data demonstrate that all children...
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: Laura F Goodman Peter T Yu Yigit Guner Saeed Awan Akhil Mohan Kevin Ge Mathew Chandy Mario S ánchez Louis Ehwerhemuepha Source Type: research
Sample entropy correlates with intraventricular hemorrhage and mortality in premature infants early in life
CONCLUSION: SE is a significant predictor of IVH and mortality in premature infants. Given IVH typically occurs in the first 24-72 HOL, affected infants may initially have low SE followed by a sustained period of high SE.IMPACT: SE correlates with IVH and mortality in preterm infants early in life. SE combined with clinical factors yielded ROC AUCs well above 0.8 and significantly outperformed the clinical model at 96 h of life. Previous studies had not shown predictive power over clinical models. First study using the PhysioNet Cardiovascular Toolbox benchmark in young infants. Relative to the generally accepted timing of...
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: Michael D Scahill Valerie Chock Katherine Travis Molly Lazarus Eric Helfenbein Melissa Scala Source Type: research
The serum thioredoxin-1 levels are not associated with bronchopulmonary dysplasia and retinopathy of prematurity
CONCLUSION: The serum TRX-1 levels after birth are not predictive of severe BPD and ROP.IMPACT: Serum thioredoxin-1 levels in extremely preterm infants on the day of birth are lower than those in term or near-term infants hospitalized for transient tachypnea of the newborn. In extremely preterm infants, the serum thioredoxin-1 levels on the day of birth, at 10-20 days of life, and at postmenstrual age of 36-40 weeks were not associated with severe bronchopulmonary dysplasia and retinopathy of prematurity. The thioredoxin system is under development in extremely preterm infants; however, the serum thioredoxin-1 level is not...
Source: Pediatric Research - February 16, 2024 Category: Pediatrics Authors: Mitsuhiro Haga Nobuhiko Nagano Junichi Ozawa Kosuke Tanaka Naoyuki Miyahara Takeshi Fujimoto Kuniya Ishii Fumihiko Namba Source Type: research
The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits
CONCLUSIONS: Anticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea.IMPACT: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Sophie J E Cramer Janneke Dekker Michelle K Croughan Katie L Lee Kelly J Crossley Erin V McGillick Tessa Martherus Martha Thio Megan J Wallace Marcus J Kitchen Stuart B Hooper Arjan B Te Pas Source Type: research
Record, reflect and refine: using video review as an initiative to improve neonatal care
CONCLUSION: Our study showed that regularly organized VR empowered healthcare providers to identify and address a large variety of areas for improvement, contributing to continuous learning and improvement processes.IMPACT: Video review empowered healthcare providers to identify areas for improvement in neonatal care Video review gave providers the opportunity to address identified areas for improvement, either by enhancing the application of external evidence (i.e. guidelines), learning from individual clinical expertise or strengthening resilience and teamwork Embedding regularly organized video review sessions allowed f...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Veerle Heesters Henriette A van Zanten Veerle Heijstek Arjan B Te Pas Ruben S G M Witlox Source Type: research
Effects of cannabidiol in post-stroke mood disorders in neonatal rats
CONCLUSIONS: These findings confirm the development of PSMD following MCAO in neonatal rats and highlight CBD as a neuroprotective agent capable of long-term functional normalization of the dopaminergic system post-MCAO.IMPACT: MCAO in neonatal rats led to post-stroke mood disorders consisting in a depression-like picture in the medium term evolving towards long-term hyperactivity, associated with an alteration of the dopaminergic system. The administration of CBD after MCAO did not prevent the development of depressive-like behavior, but reduced long-term hyperactivity, normalizing dopamine receptor function. These data p...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Mar ía Villa Mar ía Martínez-Vega Laura Silva Itziar Muneta-Arrate Ana G ómez-Soria Carolina Muguruza Aar ón Del Pozo Mar ía de Hoz-Rivera Angela Romero Luis F Callado Maria Jos é Casarejos Jos é Martínez-Orgado Source Type: research
