The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits
CONCLUSIONS: Anticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea.IMPACT: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Sophie J E Cramer Janneke Dekker Michelle K Croughan Katie L Lee Kelly J Crossley Erin V McGillick Tessa Martherus Martha Thio Megan J Wallace Marcus J Kitchen Stuart B Hooper Arjan B Te Pas Source Type: research
Record, reflect and refine: using video review as an initiative to improve neonatal care
CONCLUSION: Our study showed that regularly organized VR empowered healthcare providers to identify and address a large variety of areas for improvement, contributing to continuous learning and improvement processes.IMPACT: Video review empowered healthcare providers to identify areas for improvement in neonatal care Video review gave providers the opportunity to address identified areas for improvement, either by enhancing the application of external evidence (i.e. guidelines), learning from individual clinical expertise or strengthening resilience and teamwork Embedding regularly organized video review sessions allowed f...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Veerle Heesters Henriette A van Zanten Veerle Heijstek Arjan B Te Pas Ruben S G M Witlox Source Type: research
Effects of cannabidiol in post-stroke mood disorders in neonatal rats
CONCLUSIONS: These findings confirm the development of PSMD following MCAO in neonatal rats and highlight CBD as a neuroprotective agent capable of long-term functional normalization of the dopaminergic system post-MCAO.IMPACT: MCAO in neonatal rats led to post-stroke mood disorders consisting in a depression-like picture in the medium term evolving towards long-term hyperactivity, associated with an alteration of the dopaminergic system. The administration of CBD after MCAO did not prevent the development of depressive-like behavior, but reduced long-term hyperactivity, normalizing dopamine receptor function. These data p...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Mar ía Villa Mar ía Martínez-Vega Laura Silva Itziar Muneta-Arrate Ana G ómez-Soria Carolina Muguruza Aar ón Del Pozo Mar ía de Hoz-Rivera Angela Romero Luis F Callado Maria Jos é Casarejos Jos é Martínez-Orgado Source Type: research
The effect of vibrotactile stimulation on hypoxia-induced irregular breathing and apnea in preterm rabbits
CONCLUSIONS: Anticipated vibrotactile stimulation is more effective in preventing apnea and enhancing breathing when compared to reactive stimulation in preterm rabbits. Stimulation timing is likely to be a key factor in reducing the incidence and duration of apnea.IMPACT: Anticipated vibrotactile stimulation can prevent apnea and stimulate breathing effort in preterm rabbits. Anticipated vibrotactile stimulation increases the likelihood of breathing rate recovery following hypoxia induced irregular breathing, when compared to reactive stimulation. Automated stimulation in combination with predictive algorithms may improve...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Sophie J E Cramer Janneke Dekker Michelle K Croughan Katie L Lee Kelly J Crossley Erin V McGillick Tessa Martherus Martha Thio Megan J Wallace Marcus J Kitchen Stuart B Hooper Arjan B Te Pas Source Type: research
Record, reflect and refine: using video review as an initiative to improve neonatal care
CONCLUSION: Our study showed that regularly organized VR empowered healthcare providers to identify and address a large variety of areas for improvement, contributing to continuous learning and improvement processes.IMPACT: Video review empowered healthcare providers to identify areas for improvement in neonatal care Video review gave providers the opportunity to address identified areas for improvement, either by enhancing the application of external evidence (i.e. guidelines), learning from individual clinical expertise or strengthening resilience and teamwork Embedding regularly organized video review sessions allowed f...
Source: Pediatric Research - February 15, 2024 Category: Pediatrics Authors: Veerle Heesters Henriette A van Zanten Veerle Heijstek Arjan B Te Pas Ruben S G M Witlox Source Type: research
Global cross-sectional survey on neonatal pharmacologic sedation and analgesia practices and pain assessment tools: impact of the sociodemographic index (SDI)
CONCLUSIONS: Socio-economic status of countries impacts on neonatal analgosedation management.IMPACT: There is significant variability in the pain management practices in neonates. There is a lack of knowledge related to how neonatal pain management practices differ between regions. Sociodemographic index is a key factor associated with differences in neonatal pain management practices across global regions.PMID:38351093 | DOI:10.1038/s41390-024-03032-7 (Source: Pediatric Research)
Source: Pediatric Research - February 13, 2024 Category: Pediatrics Authors: Cristina Arribas Giacomo Cavallaro Juan-Luis Gonzalez Carolina Lagares Genny Raffaeli Anne Smits Sinno H P Simons Eduardo Villamor Karel Allegaert Felipe Garrido ESPR Special Interest Group for Neonatal Pain Source Type: research
Impact of cesarean section on metabolic syndrome components in offspring rats
CONCLUSIONS: CS offspring were more prone to adverse metabolic profile and HFF might exacerbate this condition, indicating the association between CS and MetS is likely to be causal.IMPACT: Whether the observed associations between CS and MetS in non-randomized human studies are causally relevant remains undetermined. Compared with vaginally born offspring rats, CS born offspring gained more body weight and tended to have compromised lipid profiles and abnormal insulin sensitivity, suggesting a causal relationship between CS and MetS that may be further amplified by a high-fat/high-fructose diet. Due to the high prevalence...
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Mingxuan Zhang Mengjiao Liu Long Zhang Zhangjian Chen Yu-Bo Zhou Hong-Tian Li Jian-Meng Liu Source Type: research
Hypertensive disorders of pregnancy increase the incidence of febrile seizures in offspring. A slightly blurry photo with excellent framing
Pediatr Res. 2024 Feb 12. doi: 10.1038/s41390-024-03088-5. Online ahead of print.NO ABSTRACTPMID:38347170 | DOI:10.1038/s41390-024-03088-5 (Source: Pediatric Research)
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Francesco Brigo Source Type: research
Community hospital-based clinical research: a vehicle for increasing health equity
Pediatr Res. 2024 Feb 12. doi: 10.1038/s41390-024-03055-0. Online ahead of print.NO ABSTRACTPMID:38347171 | DOI:10.1038/s41390-024-03055-0 (Source: Pediatric Research)
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Stephanie Smith Mark Waltzman Source Type: research
Concentrations of remdesivir and GS-441524 in human milk from lactating individuals diagnosed with COVID-19
Pediatr Res. 2024 Feb 12. doi: 10.1038/s41390-024-03053-2. Online ahead of print.ABSTRACTFindings from this study provide further reassuring evidence that infant exposure through human milk received from lactating individuals who require treatment with remdesivir is negligible.PMID:38347172 | DOI:10.1038/s41390-024-03053-2 (Source: Pediatric Research)
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Kerri Bertrand Yadira Sepulveda Benjamin J Spiegel Brookie M Best Raymond Suhandynata Steven Rossi Christina D Chambers Jeremiah D Momper Source Type: research
Craniofacial syndromes and class III phenotype: common genotype fingerprints? A scoping review and meta-analysis
Pediatr Res. 2024 Feb 12. doi: 10.1038/s41390-023-02907-5. Online ahead of print.ABSTRACTSkeletal Class III (SCIII) is among the most challenging craniofacial dysmorphologies to treat. There is, however, a knowledge gap regarding which syndromes share this clinical phenotype. The aims of this study were to: (i) identify the syndromes affected by the SCIII phenotype; (ii) clarify the involvement of maxillary and/or mandibular structures; (iii) explore shared genetic/molecular mechanisms. A two-step strategy was designed: [Step#1] OMIM, MHDD, HPO, GeneReviews and MedGen databases were explored; [Step#2]: Syndromic conditions...
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Maria Cristina Faria-Teixeira Cristina Tordera Francisco Salvado E Silva Ant ónio Vaz-Carneiro Alejandro Iglesias-Linares Source Type: research
Genetic susceptibility for retinopathy of prematurity and its associated comorbidities
CONCLUSION: We identified three maternal and three perinatal risk factors associated with ROP. Genes EPAS1 and AGTR1, involved in angiogenesis and vascularization, were identified to be of risk for ROP.IMPACT: Genetic and environmental risk factors associated with ROP and its comorbidities are evaluated in a Latin American population. Genes EPAS1 and AGTR1, involved in angiogenesis and vascularization, were identified to be of risk for ROP. Three maternal and three perinatal risk factors associated with ROP were also identified. A matrix of significant relationships among genetic markers and comorbidities is presented. Rep...
Source: Pediatric Research - February 12, 2024 Category: Pediatrics Authors: Lucas G Gimenez Juan A Gili Dar ío E Elias Rub én Sagula Bel én Comas Mar ía R Santos Hebe Campa ña Fernando A Poletta Silvina L Heisecke Julia Ratowiecki Viviana R Cosentino Roc ío Uranga C ésar Saleme Mercedes Negri M ónica Rittler Jorge Zapata Source Type: research
Postnatal growth and neurodevelopment at 2 years' corrected age in extremely low birthweight infants
CONCLUSIONS: Faltering postnatal growth in ELBW infants is associated with, but is poorly predictive of, developmental delay at 2 years.IMPACT: In babies born preterm, different growth references result in wide variation in categorization of faltering postnatal growth. Faltering growth in weight, length, and head circumference from 4 weeks to 36 weeks' postmenstrual age are associated with developmental delay at 2 years' corrected age, particularly motor delay. However, postnatal growth is a poor predictor of later developmental delay in extremely low birthweight infants irrespective of the growth reference used.PMID:38337...
Source: Pediatric Research - February 10, 2024 Category: Pediatrics Authors: David A Nyakotey Angelica M Clarke Barbara E Cormack Frank H Bloomfield Jane E Harding ProVIDe Study Group Source Type: research
Advocate to vaccinate: moving away from the "politics" of vaccination
Pediatr Res. 2024 Feb 9. doi: 10.1038/s41390-024-03043-4. Online ahead of print.NO ABSTRACTPMID:38337042 | DOI:10.1038/s41390-024-03043-4 (Source: Pediatric Research)
Source: Pediatric Research - February 10, 2024 Category: Pediatrics Authors: Shetal Shah Heather L Brumberg Pediatric Public Policy Council Source Type: research
Revolutionizing congenital central hypoventilation syndrome screening: the potential of machine learning approaches
Pediatr Res. 2024 Feb 10. doi: 10.1038/s41390-024-03090-x. Online ahead of print.NO ABSTRACTPMID:38341487 | DOI:10.1038/s41390-024-03090-x (Source: Pediatric Research)
Source: Pediatric Research - February 10, 2024 Category: Pediatrics Authors: Qinchang Chen Shushui Wang Source Type: research
