Early life exposure to SARS-CoV-2 and offspring neurodevelopment: detecting a non-linear relationship requires a complex approach
Pediatr Res. 2024 Feb 22. doi: 10.1038/s41390-024-03104-8. Online ahead of print.NO ABSTRACTPMID:38388821 | DOI:10.1038/s41390-024-03104-8 (Source: Pediatric Research)
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Sarah B Mulkey Gianluca Ursini Source Type: research
Development and validation of thromboembolism diagnostic algorithms in children with cancer from real-world data
CONCLUSION: This study provides a valid approach for ascertaining pediatric TE using real-world data.IMPACT: Research in pediatric thrombosis, especially cancer-related thrombosis, is limited mainly due to small-sized studies. Real-world data provide ready access to large and diverse populations. However, there are no validated algorithms for identifying thrombosis in real-world data for children. An algorithm based on combination of thrombosis and anticoagulation utilization codes had 76% sensitivity and 85% specificity to identify diagnosis of thrombosis in children in administrative data. This study provides a valid app...
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Uma Athale Jacqueline Halton Anastasia Gayowsky Anthony K C Chan Jason D Pole Source Type: research
GJ Express: an improvement initiative to decrease sedation and anesthesia for gastrojejunostomy tube exchanges
CONCLUSIONS: An interprofessional improvement initiative that engaged patients and families, incorporated pediatric-specific staff services, and developed systematic weaning was associated with a significant decrease in the overuse of sedation and anesthesia for GJ tube exchanges.IMPACT: We believe that this work is highly relevant and impactful for medical centers caring for children who require gastrojejunostomy tubes, an increasingly common approach to management of children with feeding issues. There is very little literature available on the use of sedation or anesthesia for changing these tubes. While large children'...
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Qianqian Ellie Cheng Jan Schriefer Tina Sosa Sarah Haen Samantha J Ferguson Alexander Clark Christine Boerman Carly Hochreiter Megan E Gabel Arvid Yung David E Lee Kate G Ackerman Source Type: research
ApoE: A new piece to the severe malaria puzzle
Pediatr Res. 2024 Feb 22. doi: 10.1038/s41390-024-03096-5. Online ahead of print.NO ABSTRACTPMID:38388820 | DOI:10.1038/s41390-024-03096-5 (Source: Pediatric Research)
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Emily M Stucke Jonathan G Lawton Mark A Travassos Source Type: research
Early life exposure to SARS-CoV-2 and offspring neurodevelopment: detecting a non-linear relationship requires a complex approach
Pediatr Res. 2024 Feb 22. doi: 10.1038/s41390-024-03104-8. Online ahead of print.NO ABSTRACTPMID:38388821 | DOI:10.1038/s41390-024-03104-8 (Source: Pediatric Research)
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Sarah B Mulkey Gianluca Ursini Source Type: research
Development and validation of thromboembolism diagnostic algorithms in children with cancer from real-world data
CONCLUSION: This study provides a valid approach for ascertaining pediatric TE using real-world data.IMPACT: Research in pediatric thrombosis, especially cancer-related thrombosis, is limited mainly due to small-sized studies. Real-world data provide ready access to large and diverse populations. However, there are no validated algorithms for identifying thrombosis in real-world data for children. An algorithm based on combination of thrombosis and anticoagulation utilization codes had 76% sensitivity and 85% specificity to identify diagnosis of thrombosis in children in administrative data. This study provides a valid app...
Source: Pediatric Research - February 22, 2024 Category: Pediatrics Authors: Uma Athale Jacqueline Halton Anastasia Gayowsky Anthony K C Chan Jason D Pole Source Type: research
Early career investigator biocommentary: Katherine Bline
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03097-4. Online ahead of print.NO ABSTRACTPMID:38378753 | DOI:10.1038/s41390-024-03097-4 (Source: Pediatric Research)
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Katherine E Bline Source Type: research
Molecular events in brain bilirubin toxicity revisited
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03084-9. Online ahead of print.ABSTRACTThe mechanisms involved in bilirubin neurotoxicity are still far from being fully elucidated. Several different events concur to damage mainly the neurons among which inflammation and alteration of the redox state play a major role. An imbalance of cellular calcium homeostasis has been recently described to be associated with toxic concentrations of bilirubin, and this disequilibrium may in turn elicit an inflammatory reaction. The different and age-dependent sensitivity to bilirubin damage must also be considered in describing the dra...
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Silvia Gazzin Cristina Bellarosa Claudio Tiribelli Source Type: research
Early career investigator biocommentary: Katherine Bline
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03097-4. Online ahead of print.NO ABSTRACTPMID:38378753 | DOI:10.1038/s41390-024-03097-4 (Source: Pediatric Research)
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Katherine E Bline Source Type: research
Molecular events in brain bilirubin toxicity revisited
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03084-9. Online ahead of print.ABSTRACTThe mechanisms involved in bilirubin neurotoxicity are still far from being fully elucidated. Several different events concur to damage mainly the neurons among which inflammation and alteration of the redox state play a major role. An imbalance of cellular calcium homeostasis has been recently described to be associated with toxic concentrations of bilirubin, and this disequilibrium may in turn elicit an inflammatory reaction. The different and age-dependent sensitivity to bilirubin damage must also be considered in describing the dra...
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Silvia Gazzin Cristina Bellarosa Claudio Tiribelli Source Type: research
Early career investigator biocommentary: Katherine Bline
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03097-4. Online ahead of print.NO ABSTRACTPMID:38378753 | DOI:10.1038/s41390-024-03097-4 (Source: Pediatric Research)
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Katherine E Bline Source Type: research
Molecular events in brain bilirubin toxicity revisited
Pediatr Res. 2024 Feb 20. doi: 10.1038/s41390-024-03084-9. Online ahead of print.ABSTRACTThe mechanisms involved in bilirubin neurotoxicity are still far from being fully elucidated. Several different events concur to damage mainly the neurons among which inflammation and alteration of the redox state play a major role. An imbalance of cellular calcium homeostasis has been recently described to be associated with toxic concentrations of bilirubin, and this disequilibrium may in turn elicit an inflammatory reaction. The different and age-dependent sensitivity to bilirubin damage must also be considered in describing the dra...
Source: Pediatric Research - February 20, 2024 Category: Pediatrics Authors: Silvia Gazzin Cristina Bellarosa Claudio Tiribelli Source Type: research
Early postnatal nutrition and renal consequences in preterm infants
Pediatr Res. 2024 Feb 19. doi: 10.1038/s41390-024-03080-z. Online ahead of print.ABSTRACTPerinatal nutritional factors may lead to decreased nephron endowment, decreased kidney function, and long-term development of chronic kidney disease and non-communicable diseases. At the same time, optimal postnatal nutrition and catch-up growth are associated with better neurodevelopmental outcomes in preterm infants. Therefore, nutritional management of preterm infants is a major challenge for neonatologists. In this context, the Section of Nutrition, Gastroenterology and Metabolism reviewed the current knowledge on nutritional issu...
Source: Pediatric Research - February 19, 2024 Category: Pediatrics Authors: Silvia Iacobelli Alexandre Lapillonne Farid Boubred ESPR Nutrition council members Source Type: research
Skin color influences transcutaneous bilirubin measurements: a systematic in vitro evaluation
CONCLUSION: This in vitro study provides insight into the effect of skin color on TcB measurements: the TcB is underestimated as skin pigmentation increases and this effect becomes more pronounced at higher bilirubin levels. Our results highlight the need for improved TcB meter design and cautious interpretation of TcB readings on newborns with dark skin.IMPACT: Key message: Skin color influences transcutaneous bilirubin measurements: the darker the skin, the larger the underestimation. What this study adds to existing literature: Existing literature is inconclusive regarding the influence of skin color on transcutaneous b...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Alida J Dam-Vervloet Claudia F Morsink Marleen E Krommendijk Ingrid M Nijholt Henrica L M van Straaten Lieke Poot Nienke Bosschaart Source Type: research
Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis
CONCLUSION: Antenatal betamethasone stabilizes physiologic parameters in LPS treated lambs. Budesonide mixed with surfactant further decreases injury and improves respiratory physiology in betamethasone treated animals.IMPACT: Antenatal betamethasone improved lung and systemic physiology in the setting of intra-amniotic LPS. The addition of budesonide to the surfactant further improved lung function. Budesonide levels in the plasma and lung were lower in lambs exposed to either LPS or LPS and Betamethasone animals, and these findings were not explained by increased esterification in the lungs. The combination of antenatal ...
Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Noah H Hillman Matthew W Kemp Emily Royse Hayley Grzych Haruo Usada Hideyuki Ikeda Yuki Takahashi Tsukasa Takahashi Alan H Jobe Erin Fee Source Type: research
