Postnatal budesonide improved lung function in preterm lambs exposed to antenatal steroids and chorioamnionitis

CONCLUSION: Antenatal betamethasone stabilizes physiologic parameters in LPS treated lambs. Budesonide mixed with surfactant further decreases injury and improves respiratory physiology in betamethasone treated animals.IMPACT: Antenatal betamethasone improved lung and systemic physiology in the setting of intra-amniotic LPS. The addition of budesonide to the surfactant further improved lung function. Budesonide levels in the plasma and lung were lower in lambs exposed to either LPS or LPS and Betamethasone animals, and these findings were not explained by increased esterification in the lungs. The combination of antenatal steroids and budesonide with surfactant had the lowest markers of pro-inflammatory cytokines in the lung of LPS exposed animals.PMID:38368498 | DOI:10.1038/s41390-024-03092-9

Source: Pediatric Research - February 17, 2024 Category: Pediatrics Authors: Noah H Hillman Matthew W Kemp Emily Royse Hayley Grzych Haruo Usada Hideyuki Ikeda Yuki Takahashi Tsukasa Takahashi Alan H Jobe Erin Fee Source Type: research