Lipoprotein(a) serum concentrations in children in relation to body mass index, age and sex
CONCLUSIONS: The data showed no association of Lp(a) levels in children with BMI, age or sex. Measurement of Lp(a) in youth may be useful to identify children at increased lifetime risk for ASCVD.IMPACT: In youth, Lp(a) levels are not affected by age, sex and BMI. Lp(a) risk categories remain stable over time in repeated measurements in children. Measurement of Lp(a) in children may be useful as an additional factor to identify children at increased lifetime risk for ASCVD and for reverse family screening.PMID:38418593 | DOI:10.1038/s41390-024-03108-4 (Source: Pediatric Research)
Source: Pediatric Research - February 28, 2024 Category: Pediatrics Authors: Paulina E St ürzebecher Konstantin L Uttinger Mandy Vogel Maike Schlingmann Uta Ceglarek Berend Isermann Wieland Kiess Antje K örner Ulrich Laufs Source Type: research
Nest positioning on motor development, sleep patterns, weight gain in preterm infants: systematic review
This study was constructed based on PRISMA guideline criteria. Systematic research was carried out in electronic databases: MEDLINE via PubMed, Web of Science, Scopus, and VHL-BIREME following the PICOS strategy. Studies with PTNB populations who were hospitalized in the NICU and received therapeutic NP as an intervention strategy in this population were included in this study. We sought outcomes related to sleep patterns, weight gain, and motor development. After selection, 12 studies were included in this systematic review, of which 5 (41.7%) evaluated motor development as their primary outcome, 6 (50%) sleep-wake cycle ...
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Mayara M C Carneiro Simone N S Ribeiro Nat ália A Menegol Rodrigo Okubo Dayane Montemezzo Luciana Sayuri Sanada Source Type: research
Adolescent mental health and academic performance: determining evidence-based associations and informing approaches to support in educational settings
Pediatr Res. 2024 Feb 27. doi: 10.1038/s41390-024-03098-3. Online ahead of print.NO ABSTRACTPMID:38413765 | DOI:10.1038/s41390-024-03098-3 (Source: Pediatric Research)
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Xzania Lee Anya Griffin Maya I Ragavan Mona Patel Source Type: research
Reassessing acquired neonatal intestinal diseases using unsupervised machine learning
CONCLUSION: Unsupervised machine learning can be used to cluster acquired neonatal intestinal injuries. Future study with larger multicenter datasets is needed to further refine and classify types of intestinal diseases.IMPACT: Unsupervised machine learning can be used to cluster types of acquired neonatal intestinal injury. Five major clusters of acquired neonatal intestinal injury are described, each with unique features. The clusters herein described deserve future, multicenter study to determine more specific early biomarkers and tailored therapeutic interventions to improve outcomes of often devastating neonatal acqui...
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Daniel R Gipson Alan L Chang Allison C Lure Sonia A Mehta Taylor Gowen Erin Shumans David Stevenson Diomel de la Cruz Nima Aghaeepour Josef Neu Source Type: research
Nest positioning on motor development, sleep patterns, weight gain in preterm infants: systematic review
This study was constructed based on PRISMA guideline criteria. Systematic research was carried out in electronic databases: MEDLINE via PubMed, Web of Science, Scopus, and VHL-BIREME following the PICOS strategy. Studies with PTNB populations who were hospitalized in the NICU and received therapeutic NP as an intervention strategy in this population were included in this study. We sought outcomes related to sleep patterns, weight gain, and motor development. After selection, 12 studies were included in this systematic review, of which 5 (41.7%) evaluated motor development as their primary outcome, 6 (50%) sleep-wake cycle ...
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Mayara M C Carneiro Simone N S Ribeiro Nat ália A Menegol Rodrigo Okubo Dayane Montemezzo Luciana Sayuri Sanada Source Type: research
Adolescent mental health and academic performance: determining evidence-based associations and informing approaches to support in educational settings
Pediatr Res. 2024 Feb 27. doi: 10.1038/s41390-024-03098-3. Online ahead of print.NO ABSTRACTPMID:38413765 | DOI:10.1038/s41390-024-03098-3 (Source: Pediatric Research)
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Xzania Lee Anya Griffin Maya I Ragavan Mona Patel Source Type: research
Reassessing acquired neonatal intestinal diseases using unsupervised machine learning
CONCLUSION: Unsupervised machine learning can be used to cluster acquired neonatal intestinal injuries. Future study with larger multicenter datasets is needed to further refine and classify types of intestinal diseases.IMPACT: Unsupervised machine learning can be used to cluster types of acquired neonatal intestinal injury. Five major clusters of acquired neonatal intestinal injury are described, each with unique features. The clusters herein described deserve future, multicenter study to determine more specific early biomarkers and tailored therapeutic interventions to improve outcomes of often devastating neonatal acqui...
Source: Pediatric Research - February 27, 2024 Category: Pediatrics Authors: Daniel R Gipson Alan L Chang Allison C Lure Sonia A Mehta Taylor Gowen Erin Shumans David Stevenson Diomel de la Cruz Nima Aghaeepour Josef Neu Source Type: research
Vasoactive peptides as biomarkers for the prediction of retinopathy of prematurity
CONCLUSIONS: MR-proANP and CT-proET1 measured on day seven of life are strongly associated with ROP ≥ stage II in very preterm infants and might improve early prediction of ROP in the future.IMPACT: Plasma levels of midregional pro-atrial natriuretic peptide and C-terminal pro-endothelin-1 measured on day seven of life in very preterm infants show a strong association with development of retinopathy of prematurity ≥ stage II. Both biomarkers have the potential to improve early prediction of retinopathy of prematurity. Vasoactive peptides might allow to reduce the proportion of screened infants substantially.PMID:384023...
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Roland P Neumann Roland Gerull Pascal W Hasler Sven Wellmann Sven M Schulzke Source Type: research
An egg a day keeps kernicterus away
Pediatr Res. 2024 Feb 24. doi: 10.1038/s41390-024-03103-9. Online ahead of print.NO ABSTRACTPMID:38402318 | DOI:10.1038/s41390-024-03103-9 (Source: Pediatric Research)
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Silvia Gazzin Claudio Tiribelli Source Type: research
Vasoactive peptides as biomarkers for the prediction of retinopathy of prematurity
CONCLUSIONS: MR-proANP and CT-proET1 measured on day seven of life are strongly associated with ROP ≥ stage II in very preterm infants and might improve early prediction of ROP in the future.IMPACT: Plasma levels of midregional pro-atrial natriuretic peptide and C-terminal pro-endothelin-1 measured on day seven of life in very preterm infants show a strong association with development of retinopathy of prematurity ≥ stage II. Both biomarkers have the potential to improve early prediction of retinopathy of prematurity. Vasoactive peptides might allow to reduce the proportion of screened infants substantially.PMID:384023...
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Roland P Neumann Roland Gerull Pascal W Hasler Sven Wellmann Sven M Schulzke Source Type: research
An egg a day keeps kernicterus away
Pediatr Res. 2024 Feb 24. doi: 10.1038/s41390-024-03103-9. Online ahead of print.NO ABSTRACTPMID:38402318 | DOI:10.1038/s41390-024-03103-9 (Source: Pediatric Research)
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Silvia Gazzin Claudio Tiribelli Source Type: research
Vasoactive peptides as biomarkers for the prediction of retinopathy of prematurity
CONCLUSIONS: MR-proANP and CT-proET1 measured on day seven of life are strongly associated with ROP ≥ stage II in very preterm infants and might improve early prediction of ROP in the future.IMPACT: Plasma levels of midregional pro-atrial natriuretic peptide and C-terminal pro-endothelin-1 measured on day seven of life in very preterm infants show a strong association with development of retinopathy of prematurity ≥ stage II. Both biomarkers have the potential to improve early prediction of retinopathy of prematurity. Vasoactive peptides might allow to reduce the proportion of screened infants substantially.PMID:384023...
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Roland P Neumann Roland Gerull Pascal W Hasler Sven Wellmann Sven M Schulzke Source Type: research
An egg a day keeps kernicterus away
Pediatr Res. 2024 Feb 24. doi: 10.1038/s41390-024-03103-9. Online ahead of print.NO ABSTRACTPMID:38402318 | DOI:10.1038/s41390-024-03103-9 (Source: Pediatric Research)
Source: Pediatric Research - February 24, 2024 Category: Pediatrics Authors: Silvia Gazzin Claudio Tiribelli Source Type: research
Implications of neonatal absence of innate immune mediated NF κB/AP1 signaling in the murine liver
CONCLUSIONS: These results demonstrate that developmental absence of innate immune p65/NFκB and c-Jun/AP1 signaling, and target gene expression is associated with apoptotic injury in neonatal mice. More work is needed to determine if this contributes to long-term hepatic dysfunction, and whether immunomodulatory approaches can prevent this injury.IMPACT: Various aspects of developmental immaturity of the innate immune system may help explain the increased risk of infection in the neonatal period. In adult models of inflammation and infection, innate immune signaling pathways such as p65/NFκB and c-Jun/AP1 are responsible...
Source: Pediatric Research - February 23, 2024 Category: Pediatrics Authors: Maya R Grayck William C McCarthy Mack Solar Natarajan Balasubramaniyan Lijun Zheng David J Orlicky Clyde J Wright Source Type: research
Serum endocan, asymmetric dimethylarginine and lipid profile in children with familial Mediterranean fever
CONCLUSION: Serum ADMA and lipid profile might be used as potential markers for endothelial dysfunction and increased cardiovascular risk in FMF patients.IMPACT: Theoretically, serum ADMA may affect lipid profiles and serum endocan represents an intriguing biomarker related to inflammation. Coexistence of dyslipidemia represents an additional risk factor that contributes to the onset of early atherosclerosis. A few studies investigated the role of changes in lipid profile and lipid ratios in accelerated atherosclerosis pathogenesis in FMF patients. The relationship between colchicine and lipid profile is contradictory. Alt...
Source: Pediatric Research - February 23, 2024 Category: Pediatrics Authors: Rania S El Zayat Fahima M Hassan Noran T Aboelkhair Walaa F Abdelhakeem Ahmed S Abo Hola Source Type: research
