Arginine-NO metabolites are associated with morbidity in single ventricle infants undergoing stage 2 palliation
CONCLUSION: Arginine metabolism is impaired in interstage SVHD infants and is further deranged following Stage 2 palliation. Patients with greater metabolite alterations experience greater post-op morbidity. Decreased arginine metabolism may be an important driver of pathology in SVHD.IMPACT: Interstage infants with SVHD have significantly altered arginine-nitric oxide metabolism compared to healthy children with deficiency of multiple pathway intermediates persisting through 48 h post-Stage 2 palliation. After controlling for clinical covariates and classic catheterization-derived predictors of Stage 2 readiness, both low...
Source: Pediatric Research - April 2, 2024 Category: Pediatrics Authors: Benjamin S Frank Sierra Niemiec Ludmila Khailova Christopher A Mancuso Tanner Lehmann Max B Mitchell Gareth J Morgan Mark Twite Michael V DiMaria Jelena Klawitter Jesse A Davidson Source Type: research
The role of nutritional interventions in the prevention and treatment of chronic lung disease of prematurity
Pediatr Res. 2024 Apr 2. doi: 10.1038/s41390-024-03133-3. Online ahead of print.ABSTRACTChronic lung disease of prematurity or bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Nutrition may affect incidence and severity of BPD. In this context, the Section on Nutrition, Gastroenterology and Metabolism, the Pulmonary Section of the European Society for Paediatric Research (ESPR) and SPR have joined forces to review the current knowledge on nutritional issues related to BPD. The aim of this narrative review is to discuss the clinical implications for nutritional practice. Nutrient deficiencies may ...
Source: Pediatric Research - April 2, 2024 Category: Pediatrics Authors: Miguel Saenz de Pipaon Leif D Nelin Alison Gehred Madelaine E Rossholt Sissel Moltu Chris Van den Akker Anton H van Kaam Ana S ánchez Minesh Khashu Charles C Roehr Virgilio Carnielli ESPR Nutrition council members Source Type: research
Quality of life and socioeconomic and educational status in patients with congenital hypothyroidism
CONCLUSION: SES of CH patients did not differ from matched controls. Thus, most CH patients integrate well into society, but their HRQoL is impaired.IMPACT: Most patients with primary congenital hypothyroidism integrate well into society. In the current study, their socioeconomic and marital status did not differ from matched controls at the age of 25 years. However, health-related quality of life measured using 15D instrument was impaired. Every fourth patient reported that congenital hypothyroidism influenced everyday life.PMID:38565918 | DOI:10.1038/s41390-024-03170-y (Source: Pediatric Research)
Source: Pediatric Research - April 2, 2024 Category: Pediatrics Authors: Emmi Danner Reijo Sund Harri Sintonen Laura Niuro Harri Niinikoski Hanna Huopio Liisa A Viikari Jarmo J ääskeläinen Source Type: research
Has telemedicine come to fruition? Parents' and pediatricians' perceptions and preferences regarding telemedicine
CONCLUSIONS: Understanding the factors that influence acceptance and satisfaction with telemedicine is vital for its successful implementation. Convenience, quality of care, trust, strong pediatrician-parent relationships, technical reliability, user-friendliness, and privacy considerations play significant roles in shaping parent and pediatrician attitudes toward telemedicine.IMPACT: The COVID-19 pandemic spurred the expansion of the use of telemedicine in pediatric care. Few studies have addressed parent and pediatrician perceptions and preferences regarding telemedicine. Both parents and pediatricians consider certain t...
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Nadia M Bajwa Noelle Junod Perron Olivia Braillard Sophia Achab Patricia Hudelson Melissa Dominic é Dao Robin L üchinger Sanae Mazouri-Karker Source Type: research
Citrate anticoagulation and systemic heparin anticoagulation during continuous renal replacement therapy among critically-ill children
CONCLUSION: RCA is a safe and effective anticoagulation method for CRRT in critically-ill children and it prolongs hemofilter survival.IMPACT: RCA is superior to systemic heparin for the prolongation of circuit survival (overall and for clotting-related loss) during CRRT. These data indicate that RCA can be used to maximize the effective delivery of CRRT in critically-ill patients admitted to the PICU. There are potential cost-saving implications from our results owing to benefits such as less circuit downtime and fewer circuit changes.PMID:38555381 | DOI:10.1038/s41390-024-03163-x (Source: Pediatric Research)
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Seyma Koksal Atis Muhterem Duyu Zeynep Karakaya Alev Yilmaz Source Type: research
Has telemedicine come to fruition? Parents' and pediatricians' perceptions and preferences regarding telemedicine
CONCLUSIONS: Understanding the factors that influence acceptance and satisfaction with telemedicine is vital for its successful implementation. Convenience, quality of care, trust, strong pediatrician-parent relationships, technical reliability, user-friendliness, and privacy considerations play significant roles in shaping parent and pediatrician attitudes toward telemedicine.IMPACT: The COVID-19 pandemic spurred the expansion of the use of telemedicine in pediatric care. Few studies have addressed parent and pediatrician perceptions and preferences regarding telemedicine. Both parents and pediatricians consider certain t...
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Nadia M Bajwa Noelle Junod Perron Olivia Braillard Sophia Achab Patricia Hudelson Melissa Dominic é Dao Robin L üchinger Sanae Mazouri-Karker Source Type: research
Citrate anticoagulation and systemic heparin anticoagulation during continuous renal replacement therapy among critically-ill children
CONCLUSION: RCA is a safe and effective anticoagulation method for CRRT in critically-ill children and it prolongs hemofilter survival.IMPACT: RCA is superior to systemic heparin for the prolongation of circuit survival (overall and for clotting-related loss) during CRRT. These data indicate that RCA can be used to maximize the effective delivery of CRRT in critically-ill patients admitted to the PICU. There are potential cost-saving implications from our results owing to benefits such as less circuit downtime and fewer circuit changes.PMID:38555381 | DOI:10.1038/s41390-024-03163-x (Source: Pediatric Research)
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Seyma Koksal Atis Muhterem Duyu Zeynep Karakaya Alev Yilmaz Source Type: research
Has telemedicine come to fruition? Parents' and pediatricians' perceptions and preferences regarding telemedicine
CONCLUSIONS: Understanding the factors that influence acceptance and satisfaction with telemedicine is vital for its successful implementation. Convenience, quality of care, trust, strong pediatrician-parent relationships, technical reliability, user-friendliness, and privacy considerations play significant roles in shaping parent and pediatrician attitudes toward telemedicine.IMPACT: The COVID-19 pandemic spurred the expansion of the use of telemedicine in pediatric care. Few studies have addressed parent and pediatrician perceptions and preferences regarding telemedicine. Both parents and pediatricians consider certain t...
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Nadia M Bajwa Noelle Junod Perron Olivia Braillard Sophia Achab Patricia Hudelson Melissa Dominic é Dao Robin L üchinger Sanae Mazouri-Karker Source Type: research
Citrate anticoagulation and systemic heparin anticoagulation during continuous renal replacement therapy among critically-ill children
CONCLUSION: RCA is a safe and effective anticoagulation method for CRRT in critically-ill children and it prolongs hemofilter survival.IMPACT: RCA is superior to systemic heparin for the prolongation of circuit survival (overall and for clotting-related loss) during CRRT. These data indicate that RCA can be used to maximize the effective delivery of CRRT in critically-ill patients admitted to the PICU. There are potential cost-saving implications from our results owing to benefits such as less circuit downtime and fewer circuit changes.PMID:38555381 | DOI:10.1038/s41390-024-03163-x (Source: Pediatric Research)
Source: Pediatric Research - March 30, 2024 Category: Pediatrics Authors: Seyma Koksal Atis Muhterem Duyu Zeynep Karakaya Alev Yilmaz Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
Prepuberty is a window period for curcumin to prevent obesity in postnatal overfed rats
CONCLUSION: Prepuberty is a window period for CUR intervention to improve programmed outcomes in postnatal overfed rats.IMPACT: Overnutrition during the first 1000 days of life has persistent negative effects on metabolism. Strategies should be taken to prevent overnutrition in early life to reduce the risk of obesity and metabolic disease in later life. A small-litter rat model was utilized to simulate early-life overnutrition in humans. We investigated the different effects and critical period for curcumin intervention on postnatal overfed rats. Dietary curcumin intervention before puberty could effectively transform nut...
Source: Pediatric Research - March 29, 2024 Category: Pediatrics Authors: Susu Du Nan Zhou Wen Zheng Xiaolei Zhu Ru Ling Wei Zhou Xiaonan Li Source Type: research
Centering pediatric research, advocacy, and clinical care around early relational health
Pediatr Res. 2024 Mar 27. doi: 10.1038/s41390-024-03152-0. Online ahead of print.NO ABSTRACTPMID:38538782 | DOI:10.1038/s41390-024-03152-0 (Source: Pediatric Research)
Source: Pediatric Research - March 28, 2024 Category: Pediatrics Authors: Genevieve G Guyol Joyce R Javier Source Type: research
"The forest and the trees": a narrative medicine curriculum by residents for residents
Pediatr Res. 2024 Mar 22. doi: 10.1038/s41390-024-03142-2. Online ahead of print.ABSTRACTA 7-session narrative medicine (NM) curriculum was designed and facilitated by pediatrics residents for pediatrics residents in order to unpack challenging experiences during clinical training and strengthen relationships with colleagues and patients. The primary facilitator, a resident with a master's degree in NM, provided facilitator training to her co-residents with whom she co-led the workshops in the curriculum. We conducted, transcribed, and analyzed individual interviews of 15 residents, with three resultant themes: reflection ...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Anoushka Sinha Carly S Slater Alyson Lee Harini Sridhar Deepthiman Gowda Source Type: research
Combining activity and grimace scores reflects perinatal stability in infants & lt;32 weeks gestational age
CONCLUSION: Scoring of activity and grimace was consistent between clinicians. Independently, activity and grimace did not correlate with perinatal stabilisation. Combined scoring showed non-vigorous infants had greater resuscitation requirements.IMPACT: Our study evaluates the precision and accuracy of activity and grimace to predict perinatal stability, which has not been validated in infants <32 weeks gestational age. We found strong score agreement between assessors, indicating video review is a practical and precise method for grading of activity and grimace. Combined scoring to allow a dichotomous evaluation of in...
Source: Pediatric Research - March 23, 2024 Category: Pediatrics Authors: Zachary Tuttle Calum Roberts Peter Davis Atul Malhotra Kenneth Tan Risha Bhatia Lindsay Zhou Elizabeth Baker Kate Hodgson Douglas Blank Source Type: research
