Targeted metabolomics combined with machine learning to identify and validate new biomarkers for early SLE diagnosis and disease activity
CONCLUSION: This study indicated that the tricarboxylic acid cycle might be associated with SLE drug therapy. We identified 8 diagnostic models biomarkers and 2 biomarkers that could be used to identify initial SLE and distinguish different activity degree, which will promote the development of new tools for the diagnosis and evaluation of SLE.PMID:38710348 | DOI:10.1016/j.clim.2024.110235 (Source: Clinical Immunology)
Source: Clinical Immunology - May 6, 2024 Category: Allergy & Immunology Authors: Jiabin Liang Zeping Han Jie Feng Fangmei Xie Wenfeng Luo Hanwei Chen Jinhua He Source Type: research
Complement system is overactivated in patients with IgA nephropathy after COVID-19
Clin Immunol. 2024 May 1;263:110232. doi: 10.1016/j.clim.2024.110232. Online ahead of print.ABSTRACTIgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics of patients with IgAN after COVID-19. The level of plasma level of C5a (p < 0.001), soluble C5b-9 (p = 0.018), FHR5 (p < 0.001) were all significantly higher in Group CoV (33 patients with renal biopsy-proven IgAN experienced COVID-19) compared with Group non-CoV (44 patients with IgAN wit...
Source: Clinical Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Wei-Yi Guo Guo-Qin Wang Ling-Qiang Kong Li-Jun Sun Xiao-Yi Xu Wen-Rong Cheng Hong-Rui Dong Hong Cheng Source Type: research
Complement system is overactivated in patients with IgA nephropathy after COVID-19
Clin Immunol. 2024 May 1:110232. doi: 10.1016/j.clim.2024.110232. Online ahead of print.ABSTRACTIgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics of patients with IgAN after COVID-19. The level of plasma level of C5a (p < 0.001), soluble C5b-9 (p = 0.018), FHR5 (p < 0.001) were all significantly higher in Group CoV (33 patients with renal biopsy-proven IgAN experienced COVID-19) compared with Group non-CoV (44 patients with IgAN without...
Source: Clinical Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Wei-Yi Guo Guo-Qin Wang Ling-Qiang Kong Li-Jun Sun Xiao-Yi Xu Wen-Rong Cheng Hong-Rui Dong Hong Cheng Source Type: research
Complement system is overactivated in patients with IgA nephropathy after COVID-19
Clin Immunol. 2024 May 1:110232. doi: 10.1016/j.clim.2024.110232. Online ahead of print.ABSTRACTIgA nephropathy (IgAN), which has been confirmed as a complement mediated autoimmune disease, is also one form of glomerulonephritis associated with COVID-19. Here, we aim to investigate the clinical and immunological characteristics of patients with IgAN after COVID-19. The level of plasma level of C5a (p < 0.001), soluble C5b-9 (p = 0.018), FHR5 (p < 0.001) were all significantly higher in Group CoV (33 patients with renal biopsy-proven IgAN experienced COVID-19) compared with Group non-CoV (44 patients with IgAN without...
Source: Clinical Immunology - May 3, 2024 Category: Allergy & Immunology Authors: Wei-Yi Guo Guo-Qin Wang Ling-Qiang Kong Li-Jun Sun Xiao-Yi Xu Wen-Rong Cheng Hong-Rui Dong Hong Cheng Source Type: research
Absence of ATM leads to altered NK cell function in mice
Clin Immunol. 2024 Apr 30:110233. doi: 10.1016/j.clim.2024.110233. Online ahead of print.ABSTRACTAtaxia-telangiectasia (A-T) is a rare disorder caused by genetic defects of A-T mutated (ATM) kinase, a key regulator of stress response, and characterized by neurodegeneration, immunodeficiency, and high incidence of cancer. Here we investigated NK cells in a mouse model of A-T (Atm-/-) showing that they are strongly impaired at killing tumor cells due to a block of early signaling events. On the other hand, in Atm-/- littermates with thymic lymphoma NK cell cytotoxicity is enhanced as compared with ATM-proficient mice, possib...
Source: Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Daniela Angela Covino Maria Giovanna Desimio Alessandro Giovinazzo Bruna Sabino Pinho de Oliveira Matilde Merolle Daniela Marazziti Manuela Pellegrini Margherita Doria Source Type: research
Absence of ATM leads to altered NK cell function in mice
Clin Immunol. 2024 Apr 30:110233. doi: 10.1016/j.clim.2024.110233. Online ahead of print.ABSTRACTAtaxia-telangiectasia (A-T) is a rare disorder caused by genetic defects of A-T mutated (ATM) kinase, a key regulator of stress response, and characterized by neurodegeneration, immunodeficiency, and high incidence of cancer. Here we investigated NK cells in a mouse model of A-T (Atm-/-) showing that they are strongly impaired at killing tumor cells due to a block of early signaling events. On the other hand, in Atm-/- littermates with thymic lymphoma NK cell cytotoxicity is enhanced as compared with ATM-proficient mice, possib...
Source: Clinical Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Daniela Angela Covino Maria Giovanna Desimio Alessandro Giovinazzo Bruna Sabino Pinho de Oliveira Matilde Merolle Daniela Marazziti Manuela Pellegrini Margherita Doria Source Type: research
Animal models of studying the pathogenesis of multi-organ tissue damage in lupus
Clin Immunol. 2024 Apr 29:110231. doi: 10.1016/j.clim.2024.110231. Online ahead of print.ABSTRACTModerate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive autoantibody deposition and persistent autoinflammation. As the existing animal models are limited in accurately reproducing the pathological characteristics of human SLE, we introduced a novel animal model simulating multi-organ autoinflammation through intra-organ injections. The model closely mimicked key features of SLE, including IgG deposition, inflammation, and tissue damage. The model could be used to assess the roles of IgG, immune cell...
Source: Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Xuefei Wang Guo-Min Deng Source Type: research
Animal models of studying the pathogenesis of multi-organ tissue damage in lupus
Clin Immunol. 2024 Apr 29:110231. doi: 10.1016/j.clim.2024.110231. Online ahead of print.ABSTRACTModerate-to-severe systemic lupus erythematosus (SLE) is characterized by extensive autoantibody deposition and persistent autoinflammation. As the existing animal models are limited in accurately reproducing the pathological characteristics of human SLE, we introduced a novel animal model simulating multi-organ autoinflammation through intra-organ injections. The model closely mimicked key features of SLE, including IgG deposition, inflammation, and tissue damage. The model could be used to assess the roles of IgG, immune cell...
Source: Clinical Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Xuefei Wang Guo-Min Deng Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling
In this study, we aimed to illustrate the effect of EPX on the epithelial-mesenchymal transition (EMT) in BEAS-2B cells. Our research found that both EPX and ADAM33 were negatively correlated with FEV1/FVC and FEV1%pred, and positively correlated with IL-5 levels. Asthma patients had relatively higher levels of ADAM33 and EPX compared to the healthy control group. The expression of TSLP, TGF-β1 and ADAM33 in the EPX intervention group was significantly higher. Moreover, EPX could promote the proliferation, migration and EMT of BEAS-2B cells, and the effect of EPX on various factors was significantly improved by the PI3K i...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Liping Xu Xuemei Huang Zhangrong Chen Meiling Yang Jingmin Deng Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling
In this study, we aimed to illustrate the effect of EPX on the epithelial-mesenchymal transition (EMT) in BEAS-2B cells. Our research found that both EPX and ADAM33 were negatively correlated with FEV1/FVC and FEV1%pred, and positively correlated with IL-5 levels. Asthma patients had relatively higher levels of ADAM33 and EPX compared to the healthy control group. The expression of TSLP, TGF-β1 and ADAM33 in the EPX intervention group was significantly higher. Moreover, EPX could promote the proliferation, migration and EMT of BEAS-2B cells, and the effect of EPX on various factors was significantly improved by the PI3K i...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Liping Xu Xuemei Huang Zhangrong Chen Meiling Yang Jingmin Deng Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling
In this study, we aimed to illustrate the effect of EPX on the epithelial-mesenchymal transition (EMT) in BEAS-2B cells. Our research found that both EPX and ADAM33 were negatively correlated with FEV1/FVC and FEV1%pred, and positively correlated with IL-5 levels. Asthma patients had relatively higher levels of ADAM33 and EPX compared to the healthy control group. The expression of TSLP, TGF-β1 and ADAM33 in the EPX intervention group was significantly higher. Moreover, EPX could promote the proliferation, migration and EMT of BEAS-2B cells, and the effect of EPX on various factors was significantly improved by the PI3K i...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Liping Xu Xuemei Huang Zhangrong Chen Meiling Yang Jingmin Deng Source Type: research
Streptococcus pneumoniae endopeptidase O induces trained immunity against numerous pathogen infections, a key role for G-CSF
Clin Immunol. 2024 Apr 23:110226. doi: 10.1016/j.clim.2024.110226. Online ahead of print.ABSTRACTAntibiotic resistance and the surge of infectious diseases during the pandemic present significant threats to human health. Trained immunity emerges as a promising and innovative approach to address these infections. Synthetic or natural fungal, parasitic and viral components have been reported to induce trained immunity. However, it is not clear whether bacterial virulence proteins can induce protective trained immunity. Our research demonstrates Streptococcus pneumoniae virulence protein PepO, is a highly potent trained immun...
Source: Clinical Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Wenlong Xu Yuan Yuan Zhaoche Shu Ting Guo Bichen Liu Jiangming Xiao Lian Li Yibin Yin Xuemei Zhang Source Type: research
