Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Immunopeptidome mining reveals a novel ERS-induced target in T1D
This study provides not only a new explanation for the role of ERS in promoting β-cell-targeted autoimmunity but also a potential target for the prevention and treatment of T1D. The data are available via ProteomeXchange with the identifier PXD041227.PMID:38689020 | DOI:10.1038/s41423-024-01150-0 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 30, 2024 Category: Molecular Biology Authors: Lina Wang Shushu Yang Gaohui Zhu Jie Li Gang Meng Xiaoling Chen Mengjun Zhang Shufeng Wang Xiangqian Li Yu Pan Yi Huang Li Wang Yuzhang Wu Source Type: research
Tissue-specific features of innate lymphoid cells in antiviral defense
Cell Mol Immunol. 2024 Apr 29. doi: 10.1038/s41423-024-01161-x. Online ahead of print.ABSTRACTInnate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microe...
Source: Cellular and Molecular Immunology - April 29, 2024 Category: Molecular Biology Authors: Sytse J Piersma Source Type: research
Tissue-specific features of innate lymphoid cells in antiviral defense
Cell Mol Immunol. 2024 Apr 29. doi: 10.1038/s41423-024-01161-x. Online ahead of print.ABSTRACTInnate lymphocytes (ILCs) rapidly respond to and protect against invading pathogens and cancer. ILCs include natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells and include type I, type II, and type III immune cells. While NK cells have been well recognized for their role in antiviral immunity, other ILC subtypes are emerging as players in antiviral defense. Each ILC subset has specialized functions that uniquely impact the antiviral immunity and health of the host depending on the tissue microe...
Source: Cellular and Molecular Immunology - April 29, 2024 Category: Molecular Biology Authors: Sytse J Piersma Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Inhibition of METTL3 in macrophages provides protection against intestinal inflammation
In this study, we discovered that increased expression of methyltransferase-like 3 (METTL3) in macrophages was correlated with the development of colitis and that depletion of METTL3 in macrophages protected mice against dextran sodium sulfate (DSS)-induced colitis. Mechanistic characterization indicated that METTL3 depletion increased the YTHDF3-mediated expression of phosphoglycolate phosphatase (PGP), which resulted in glucose metabolism reprogramming and the suppression of CD4+ T helper 1 (Th1) cell differentiation. Further analysis revealed that glucose metabolism contributed to the ability of METTL3 depletion to amel...
Source: Cellular and Molecular Immunology - April 22, 2024 Category: Molecular Biology Authors: Huilong Yin Zhuan Ju Xiang Zhang Wenjie Zuo Yuhang Yang Minhua Zheng Xiaofang Zhang Yuning Liu Yingran Peng Ying Xing Angang Yang Rui Zhang Source Type: research
Lkb1 orchestrates γδ T-cell metabolic and functional fitness to control IL-17-mediated autoimmune hepatitis
In this study, we investigated the role of liver kinase B1 (Lkb1), a serine/threonine kinase that links cellular metabolism with cell growth and proliferation, in γδ T-cell biology. Our findings demonstrate that Lkb1 is not only involved in regulating γδ T lineage commitment but also plays a critical role in γδ T-cell effector function. Specifically, T-cell-specific deletion of Lkb1 resulted in impaired thymocyte development and distinct alterations in γδ T-cell subsets in both the thymus and peripheral lymphoid tissues. Notably, loss of Lkb1 inhibited the commitment of Vγ1 and Vγ4 γδ T cells, promoted the matu...
Source: Cellular and Molecular Immunology - April 19, 2024 Category: Molecular Biology Authors: Zhiqiang Xiao Shanshan Wang Liang Luo Wenkai Lv Peiran Feng Yadong Sun Quanli Yang Jun He Guangchao Cao Zhinan Yin Meixiang Yang Source Type: research
Targeting macrophage metabolism to enhance tumor immunotherapy
Cell Mol Immunol. 2024 Apr 17. doi: 10.1038/s41423-024-01149-7. Online ahead of print.NO ABSTRACTPMID:38632383 | DOI:10.1038/s41423-024-01149-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 17, 2024 Category: Molecular Biology Authors: Jing Liu Zhibo Ma Wenlong Jia Peixiang Lan Source Type: research
Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases
Cell Mol Immunol. 2024 Apr 17. doi: 10.1038/s41423-024-01162-w. Online ahead of print.NO ABSTRACTPMID:38632384 | DOI:10.1038/s41423-024-01162-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 17, 2024 Category: Molecular Biology Authors: Xiurong Wu Zhang-Hua Yang Yue Zheng Jianfeng Wu Jiahuai Han Source Type: research
Neuropilin-1 < sup > high < /sup > monocytes protect against neonatal inflammation
In this study, we identified a subset of neonatal monocytes characterized by high levels of neuropilin-1 (Nrp1), termed Nrp1high monocytes. Compared with their Nrp1low counterparts, Nrp1high monocytes displayed potent immunosuppressive activity. Nrp1 deficiency in myeloid cells aggravated the severity of NEC, whereas adoptive transfer of Nrp1high monocytes led to remission of NEC. Mechanistic studies showed that Nrp1, by binding to its ligand Sema4a, induced intracellular p38-MAPK/mTOR signaling and activated the transcription factor KLF4. KLF4 transactivated Nos2 and enhanced the production of nitric oxide (NO), a key med...
Source: Cellular and Molecular Immunology - April 17, 2024 Category: Molecular Biology Authors: Xiaoqing Zheng Wen Lei Yongmei Zhang Han Jin Cha Han Fan Wu Chonghong Jia Ruihong Zeng Zhanghua Chen Yuxia Zhang Haitao Wang Qiang Liu Zhi Yao Ying Yu Jie Zhou Source Type: research
Targeting macrophage metabolism to enhance tumor immunotherapy
Cell Mol Immunol. 2024 Apr 17. doi: 10.1038/s41423-024-01149-7. Online ahead of print.NO ABSTRACTPMID:38632383 | DOI:10.1038/s41423-024-01149-7 (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 17, 2024 Category: Molecular Biology Authors: Jing Liu Zhibo Ma Wenlong Jia Peixiang Lan Source Type: research
Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases
Cell Mol Immunol. 2024 Apr 17. doi: 10.1038/s41423-024-01162-w. Online ahead of print.NO ABSTRACTPMID:38632384 | DOI:10.1038/s41423-024-01162-w (Source: Cellular and Molecular Immunology)
Source: Cellular and Molecular Immunology - April 17, 2024 Category: Molecular Biology Authors: Xiurong Wu Zhang-Hua Yang Yue Zheng Jianfeng Wu Jiahuai Han Source Type: research
