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Drug: Dexamethasone
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Total 6494 results found since Jan 2013.
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus
This study showed that tacrolimus could directly upregulate the expression of IL-37 in human gingival epithelial cells by promoting the TGF-βRI/Smad3 pathway independently of calcineurin inhibition and MAPKs. In contrast, dexamethasone, one of the corticosteroids, did not have the same effect. Moreover, IL-37 could inhibit the proliferation of activated T cells and the secretion of effector cytokines and alleviate epithelial cell apoptosis and death caused by activated T cells ina co-culturesystem. Furthermore, compared with healthy controls, IL-37 and p-Smad3 levels significantly increased in the oral mucosa affected by ...
Source: Biochemical Pharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Zhangci Su Jingyi Lu Zihang Ling Wei Li Xi Yang Bin Cheng Xiaoan Tao Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Unveiling pro-angiogenesis and drug delivery using dual-bio polymer with bio-ceramic based nanocomposite hydrogels
Chemosphere. 2023 Sep 8:140131. doi: 10.1016/j.chemosphere.2023.140131. Online ahead of print.ABSTRACTIn regenerative medicine, blood vessel development is of utmost importance as it enables the restoration of blood flow to tissues, and facilitate rapid vascularization in clinical tissue-engineered grafts. Herein, we fabricate the nanocomposite hydrogels from BG, alginate, Polyethylene glycol (PEG) and Dexamethasone (DEX) for the dual applications of drug delivery and angiogenesis assay. The hydrogels were fabricated through cross-linking approach and termed as alginate/PEG (A), alginate/PEG/clinophosinaite (AC), and algin...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: K Elakkiya P Bargavi S Balakumar Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Klf9 plays a critical role in GR -dependent metabolic adaptations in cardiomyocytes
We examined the role of Krüppel-like factor 9 (Klf9), an early direct target of GR in cardiomyocytes. Klf9-ChIPseq identified 2150 genes that showed an increase in Klf9 binding in response to Dex. Transcriptome analysis of Dex treated cardiomyocytes with or without knockdown of Klf9 revealed differential regulation of 1777 genes, of which a reversal in expression is seen in 1640 genes with knockdown of Klf9 compared to Dex. Conversely, only 137 (~8%) genes show further dysregulation in expression with siKLf9 as seen with Dex treated cardiomyocytes. Functional annotation identified genes of metabolic pathways on the top of...
Source: Cellular Signalling - September 10, 2023 Category: Cytology Authors: Chandni Thakkar Saleena Alikunju Nandita Niranjan Wajiha Rizvi Ali Abbas Maha Abdellatif Danish Sayed Source Type: research
Topical formulations of Aprepitant are safe and effective in relieving pain and inflammation, and drive neural regeneration
CONCLUSIONS: Aprepitant X formulation is a promising candidate for the treatment of pain associated with inflammation of the ocular surface.PMID:37690516 | DOI:10.1016/j.jtos.2023.09.004
Source: The Ocular Surface - September 10, 2023 Category: Opthalmology Authors: Filippo Bonelli Ibrahim Demirsoy Romina Mayra Lasagni Vitar Philippe Fonteyne Giulio Ferrari Source Type: research
Efficacy and safety of a dexamethasone-based mouthwash to prevent chemotherapy-induced stomatitis in women with breast cancer: a multicentre, open-label, randomised phase 2 study
CONCLUSIONS: The dexamethasone-based mouthwash safely reduced stomatitis incidence and severity in patients receiving chemotherapy for early breast cancer. Phase 3 clinical trials are warranted for validating our results.PMID:37689451 | DOI:10.1016/j.jebdp.2023.101896
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Sayaka Kuba Shigeto Maeda Kenichiro Shibata Sakiko Soutome Kosho Yamanouchi Megumi Matsumoto Aya Tanaka Michi Morita Toshiko Hatachi Ryota Otsubo Hiroshi Yano Yumiko Kawashita Shuntaro Sato Hideki Taniguchi Kengo Kanetaka Masahiro Umeda Takeshi Nagayasu S Source Type: research
Anti-NMDAR encephalitis secondary to acute necrotizing encephalopathy caused by herpes simplex virus infection in infants: Case series
CONCLUSION: Infants with ANE associated with HSV can develop secondary anti-NMDAR encephalitis, recognition of which is critical to ensure the appropriate institution of immunotherapy after active CNS infection has been ruled out.PMID:37689014 | DOI:10.1016/j.clineuro.2023.107955
Source: Herpes - September 9, 2023 Category: Infectious Diseases Authors: Jia Zhang Jinfeng Liu Jianjun Wang Jing Gan Source Type: research
Intratympanic dexamethasone in Mani ères disease and symptom control
CONCLUSION: ITD application shows improvement in controlling vertigo and tinnitus in patients under exacerbation in MD.SIGNIFICANCE: It is a promising non-destructive addition to the 'stepwise treatment concept' in MD and can be used as a first-line treatment in vertigo control.PMID:37682583 | DOI:10.1080/00016489.2023.2244003
Source: Acta Oto-Laryngologica - September 8, 2023 Category: ENT & OMF Authors: Tatjana Tomanovic Source Type: research
