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Anti-inflammatory Effects of Ziziphus Jujube Mill on LPS-induced Acute Lung Injury in Mice
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):281-289. doi: 10.18502/ijaai.v22i3.13056.ABSTRACTZiziphus Jujuba Mill (Z.J) is a well-known ethnomedical source of biologically active compounds with anti-inflammatory effects. However, its significance in acute lung injury (ALI) has never been studied. The present study aimed to explore whether Z.J could attenuate lipopolysaccharide (LPS)-induced inflammatory responses in an experimental model of ALI. Male BALB/c mice received an intratracheal administration of LPS (n=32) or phosphate buffer saline (PBS) (control, n=8). Within 1, 11, and 23 h post-LPS injection, mice were r...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 31, 2023 Category: Allergy & Immunology Authors: Parastoo Shaban Niloofar Honari Nafiseh Erfanian Mehran Hosseini Hossein Safarpour Saeed Nasseri Source Type: research

The Anti-Inflammatory and Skin Barrier Function Recovery Effects of < em > Schisandra chinensis < /em > in Mice with Atopic Dermatitis
Conclusions: These results suggest that S. chinensis can be used as an alternative to external corticosteroids and that its anti-inflammatory and skin barrier dysfunction-restoring effects are related to the downregulation of pro-inflammatory cytokines and chemokines, such as TNF-α, IL-4, IL-6, IL-8, and TSLP.PMID:37512164 | DOI:10.3390/medicina59071353
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yoorae Son Wonjin Yang Sangjun Park Jinkyu Yang Soyeon Kim Ji-Hyo Lyu Hyungwoo Kim Source Type: research

Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research

The Anti-Inflammatory and Skin Barrier Function Recovery Effects of < em > Schisandra chinensis < /em > in Mice with Atopic Dermatitis
Conclusions: These results suggest that S. chinensis can be used as an alternative to external corticosteroids and that its anti-inflammatory and skin barrier dysfunction-restoring effects are related to the downregulation of pro-inflammatory cytokines and chemokines, such as TNF-α, IL-4, IL-6, IL-8, and TSLP.PMID:37512164 | PMC:PMC10385087 | DOI:10.3390/medicina59071353
Source: Medicina (Kaunas) - July 29, 2023 Category: Universities & Medical Training Authors: Yoorae Son Wonjin Yang Sangjun Park Jinkyu Yang Soyeon Kim Ji-Hyo Lyu Hyungwoo Kim Source Type: research

A retrospective analysis of clinical features and treatment outcome in 21 patients with immunoglobulin M-related light-chain amyloidosis in Japan: a study from the Amyloidosis Research Committee
Int J Hematol. 2023 Jul 29. doi: 10.1007/s12185-023-03647-2. Online ahead of print.ABSTRACTWe retrospectively gathered data of 21 patients (13 male and 8 female; median age 65 years) diagnosed with immunoglobulin M (IgM)-related light-chain (AL) amyloidosis in Japan to investigate characteristics of IgM-AL amyloidosis and its optimal treatment strategy. Median IgM and difference free light chain (FLC) at diagnosis were 1257 mg/dl and 34.3 mg/l, respectively. Organ involvement was observed in the heart in 7 patients (33%), kidneys in 15 (71%), and lymph nodes in 5 (24%). Initial treatments were melphalan/dexamethasone in 7 ...
Source: International Journal of Hematology - July 29, 2023 Category: Hematology Authors: Shin-Ichi Fuchida Mizuki Ogura Tadao Ishida Hiroyuki Hata Hiroshi Handa Nagaaki Katoh Chiaki Nakaseko Kazutaka Sunami Yuta Katayama Hironobu Nobata Kazuiku Oshiro Shinsuke Iida Yoshiki Sekijima Hironobu Naiki Chihiro Shimazaki Source Type: research