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An experimental approach to determine the gamma radiation interaction mean free path and exposure buildup factor for biomolecules
Appl Radiat Isot. 2023 Sep 6;201:111012. doi: 10.1016/j.apradiso.2023.111012. Online ahead of print.ABSTRACTThis experimental approach was designed to understand the gamma interaction parameters for the essential biomolecules, including starch soluble, cholesterol, myristic acid, glucose, oxalic acid, dextrose, salicylic acid, ethyl cellulose and sucrose. The empirical determination of gamma interaction parameters, such as interaction mean-free-path (MFP), buildup factor, and effective atomic number (Zeff) was performed by measuring mass attenuation coefficient (μ/ρ) at energies of 356 keV, 511 keV, 662 keV, 1173 keV, 12...
Source: Applied Radiation and Isotopes - September 13, 2023 Category: Radiology Authors: None Manjunatha M M Hosamani G B Hiremath A Vinayak V P Singh A S Bennal N M Badiger Source Type: research
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Cell Mol Life Sci. 2023 Sep 14;80(10):291. doi: 10.1007/s00018-023-04914-5.ABSTRACTLipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription. Tran...
Source: Cellular and Molecular Life Sciences : CMLS - September 13, 2023 Category: Cytology Authors: Hagyu Kim Sung Jae Shin Source Type: research
An experimental approach to determine the gamma radiation interaction mean free path and exposure buildup factor for biomolecules
Appl Radiat Isot. 2023 Sep 6;201:111012. doi: 10.1016/j.apradiso.2023.111012. Online ahead of print.ABSTRACTThis experimental approach was designed to understand the gamma interaction parameters for the essential biomolecules, including starch soluble, cholesterol, myristic acid, glucose, oxalic acid, dextrose, salicylic acid, ethyl cellulose and sucrose. The empirical determination of gamma interaction parameters, such as interaction mean-free-path (MFP), buildup factor, and effective atomic number (Zeff) was performed by measuring mass attenuation coefficient (μ/ρ) at energies of 356 keV, 511 keV, 662 keV, 1173 keV, 12...
Source: Applied Radiation and Isotopes - September 13, 2023 Category: Radiology Authors: None Manjunatha M M Hosamani G B Hiremath A Vinayak V P Singh A S Bennal N M Badiger Source Type: research
AMFR promotes innate immunity activation and proteasomal degradation of HMGCR in response to influenza virus infection in A549 cells
Virology. 2023 Aug 31;587:109875. doi: 10.1016/j.virol.2023.109875. Online ahead of print.ABSTRACTDifferential regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which is considered the rate-limiting enzyme of the cholesterol biosynthesis pathway, has been reported in case of infection with many viruses. In our study, we have found that influenza virus infection decreases total cellular cholesterol level which is directly related to the downregulation of HMGCR protein. We found that HMGCR is degraded through ubiquitination and proteasomal-mediated pathway upon viral infection. Upregulation of Autocr...
Source: Virology - September 13, 2023 Category: Virology Authors: Devendra Nath Tewari Asim Biswas Alok Kumar Chakrabarti Shanta Dutta Source Type: research
Cholesterol reprograms glucose and lipid metabolism to promote proliferation in colon cancer cells
Cancer Metab. 2023 Sep 13;11(1):15. doi: 10.1186/s40170-023-00315-1.ABSTRACTHypercholesterolemia is often correlated with obesity which is considered a risk factor for various cancers. With the growing population of hypercholesterolemic individuals, there is a need to understand the role of increased circulatory cholesterol or dietary cholesterol intake towards cancer etiology and pathology. Recently, abnormality in the blood cholesterol level of colon cancer patients has been reported. In the present study, we demonstrate that alteration in cholesterol levels (through a high-cholesterol or high-fat diet) increases the inc...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Shyamananda Singh Mayengbam Abhijeet Singh Himanshi Yaduvanshi Firoz Khan Bhati Bhavana Deshmukh Dipti Athavale Pranay L Ramteke Manoj Kumar Bhat Source Type: research
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Cell Mol Life Sci. 2023 Sep 14;80(10):291. doi: 10.1007/s00018-023-04914-5.ABSTRACTLipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription. Tran...
Source: Cellular and Molecular Life Sciences : CMLS - September 13, 2023 Category: Cytology Authors: Hagyu Kim Sung Jae Shin Source Type: research
Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
CONCLUSION: This study suggested that NAFLD is associated with a reduced risk of reduced heel bone mass. More research needs to be done to back up the results of this study and look into possible problems.PMID:37705028 | DOI:10.1186/s13018-023-04168-8
Source: Hand Surgery - September 13, 2023 Category: Surgery Authors: Guangheng Zhang Yingsong Zhao Siyuan Wang Qing Gong Hewei Li Source Type: research
Lipoproteins, Cholesterol, and Atherosclerotic Cardiovascular Disease in East Asians and Europeans
J Atheroscler Thromb. 2023 Sep 14. doi: 10.5551/jat.RV22013. Online ahead of print.ABSTRACTOne fifth of the world population live in East Asia comprising Japan, Korea, and China where ischemic heart disease, a major component of atherosclerotic cardiovascular disease (ASCVD), is the second most frequent cause of death. Each of low-density lipoproteins (LDL), remnant lipoproteins, and lipoprotein(a), summarized as non-high-density lipoproteins (non-HDL) or apolipoprotein B (apoB) containing lipoproteins, causes ASCVD. However, a significant proportion of the evidence on lipoproteins and lipoprotein cholesterol with risk of ...
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Takahito Doi Anne Langsted B ørge G Nordestgaard Source Type: research
Variability in Plasma Lipids Between Intensive Statin Therapy and Conventional-Dose Statins Combined with Ezetimibe Therapy in Patients with Coronary Atherosclerosis Disease
In this study, we aimed to examine the variability in plasma lipids under two different lipid-lowering regimens (intensive statin therapy versus the combination of conventional-dose statins with ezetimibe). In total, we have retrospectively examined 1275 patients with CAD from January 2009 to April 2019 and divided them into two groups: intensive statin group and conventional-dose statins combined with ezetimibe group. All patients were followed up for at least 1 year. Lipid variability was verified by standard deviation (SD), coefficient of variation (CV), and variability independent of mean (VIM) triple methods. Multiple...
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Jinhua Jin Liwen Shan Manjun Wang Lu Liu Tian Xu Duanbin Li Zhezhe Chen Xianglan Liu Wenbin Zhang Ya Li Source Type: research
Association of Coronary Artery Calcium Detected by Routine Ungated CT Imaging With Cardiovascular Outcomes
CONCLUSIONS: Incidental CAC ≥100 was associated with an increased risk of all-cause death and adverse cardiovascular outcomes, beyond traditional risk factors. DL-CAC from routine non-ECG-gated CTs identifies patients at increased cardiovascular risk and holds promise as a tool for opportunistic screening to facilitate earlier intervention.PMID:37704309 | DOI:10.1016/j.jacc.2023.06.040
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Allison W Peng Ramzi Dudum Sneha S Jain David J Maron Bhavik N Patel Nishith Khandwala David Eng Akshay S Chaudhari Alexander T Sandhu Fatima Rodriguez Source Type: research
Proniosomes Nanoparticle for the Treatment of Peripheral Arterial Disease
CONCLUSION: Proniosomes may be created using various techniques, which may impact how they develop along with the drug's characteristics. They increase the drug's stability while being delivered while being entrapped. They don't need particular conditions for handling, protection, storage, or industrial manufacturing.PMID:37702235 | DOI:10.2174/2211738511666230912160729
Source: Atherosclerosis - September 13, 2023 Category: Cardiology Authors: Preyash A Panchal Shruti Patel Asha Patel Priyanka Ahlawat Source Type: research
Association of oxidized ApoB and oxidized ApoA-I with high-risk coronary plaque features in cardiovascular disease
CONCLUSION: Our findings suggest that the investigated OMLs are associated with high-risk coronary plaque features and progression over time in CVD patients.TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov. Unique identifier: NCT01621594.FUNDING: This work was supported by the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health Intramural Research Program. The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript f...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Alexander V Sorokin Christin G Hong Angel M Aponte Elizabeth M Florida Jingrong Tang Nidhi Patel Irina N Baranova Haiou Li Philip M Parel Vicky Chen Sierra R Wilson Emily L Ongstad Anna Coll én Martin P Playford Thomas L Eggerman Marcus Y Chen Kazuhiko K Source Type: research
Flunitrazepam and its metabolites exposure disturb the zebrafish gut-liver axis: Combined microbiome and metabolomic analysis
In this study, we investigated the effects of the benzodiazepine drug flunitrazepam (FLZ) and its metabolite 7-aminoflunitrazepam (7-FLZ) on the gut-liver axis of zebrafish. Zebrafish were exposed to two concentrations of FLZ and 7-FLZ (0.05 and 1 μg/L) for 30 days. Results showed that both FLZ and 7-FLZ exposure altered the relative abundance of Proteobacteria at the phylum level, with significant differences observed at the genus level for pathogenic bacteria such as Paracoccus, Shewanella, and Aeromonas. Metabolomics results showed both exposures significantly interfered with nucleotide and amino acid metabolism. The i...
Source: Aquatic Toxicology - September 12, 2023 Category: Toxicology Authors: Wenting Lin Yingjun Qin Xinying Wang Mingluo Du Yukai Wang Xiaohui Chen Yuan Ren Source Type: research
Construction of the Gal-NH < sub > 2 < /sub > /mulberry leaf polysaccharides-lysozyme/luteolin nanoparticles and the amelioration effects on lipid accumulation
This study provides a promising strategy for a highly hepatic-targeted therapy to ameliorate lipid accumulation using natural medicines facilitated by nano-technology.PMID:37699459 | DOI:10.1016/j.ijbiomac.2023.126780
Source: International Journal of Biological Macromolecules - September 12, 2023 Category: Biochemistry Authors: Ruilin Li Jingna Zhou Xiaoyu Zhang Yajie Wang Jia Wang Min Zhang Chengwei He Pengwei Zhuang Haixia Chen Source Type: research
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
