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Total 42422 results found since Jan 2013.
Effects of combined strength and endurance training on exercise capacity in kidney transplant cyclists and runners
CONCLUSIONS: These findings indicate that the combined strength and endurance training is well tolerated and may improve exercise performance in this selected population of KTRs.PMID:37712239 | DOI:10.4415/ANN_23_03_07
Source: Ann Ist Super Sanita - September 15, 2023 Category: Biomedical Science Authors: Valentina Totti Rocco Di Michele Giulio Sergio Roi Sandro Bartolomei Giovanni Mosconi Gianluigi Sella Alessandro Nanni Costa Gabriela Sangiorgi Manuela Trerotola Lia Bellis Franco Merni Massimo Cardillo Source Type: research
Thymoquinone attenuates olanzapine-induced metabolic disorders in rats
CONCLUSIONS: The present study demonstrates the effectiveness of TQ on OLZ-induced metabolic abnormalities related to its antioxidant activity and regulation of glucose homeostasis and lipid metabolism.PMID:37707771 | DOI:10.1007/s11033-023-08726-5
Source: Molecular Biology Reports - September 14, 2023 Category: Molecular Biology Authors: Farima Kaviani Bibi Marjan Razavi Mahdieh Sadat Mohsenzadeh Maryam Rameshrad Hossein Hosseinzadeh Source Type: research
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Infect Genet Evol. 2023 Sep 12:105501. doi: 10.1016/j.meegid.2023.105501. Online ahead of print.ABSTRACTThe primary vector of the trypanosome parasite causing human and animal African trypanosomiasis in Uganda is the riverine tsetse fly Glossina fuscipes fuscipes (Gff). Our study improved the Gff genome assembly with whole genome 10× Chromium sequencing of a lab reared pupae, identified autosomal versus sex-chromosomal regions of the genome with ddRAD-seq data from 627 field caught Gff, and identified SNPs associated with trypanosome infection with genome-wide association (GWA) analysis in a subset of 351 flies. Results f...
Source: Infection, Genetics and Evolution - September 14, 2023 Category: Genetics & Stem Cells Authors: Norah P Saarman Jae Hak Son Hongyu Zhao Luciano V Cosme Yong Kong Mo Li Shiyu Wang Brian L Weiss Richard Echodu Robert Opiro Serap Aksoy Adalgisa Caccone Source Type: research
Effect of various dietary fructose concentrations on the gallstone formation process in mice
CONCLUSION: changes in plasma, liver and bile lipids were only observed at very high fructose concentrations diets. We conclude that fructose apparently does not alter the gallstone formation process in our experimental model.PMID:37705438 | DOI:10.20960/nh.04610
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Reginald Del Pozo Iribarren Lorena Mardones Marcelo Villagr án Katia Mu ñoz Luciano Troncoso Maximiliano Mellado Mirna Mu ñoz Source Type: research
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cognitive impairment or dementia or hemorrhagic stroke. The writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize existing evidence and to identify gaps in current knowledge. Although some retrospective, case control, and prospective lon...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Larry B Goldstein Peter P Toth Jennifer L Dearborn-Tomazos Robert P Giugliano Benjamin J Hirsh Jessica M Pe ña Magdy H Selim Daniel Woo American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Source Type: research
Inflammation and oxidative stress markers in type 2 diabetes patients with Advanced Carotid atherosclerosis
CONCLUSION: Our study is in line with a key role for inflammation in the pathogenesis of diabetic atherosclerosis and highlights the involvement of 2-AA-LPC. Further research is needed to better understand the local processes involved in the alteration of plaque composition in T2DM and to identify potential therapeutic targets.TRIAL REGISTRATION: The MASCADI was registered on ClinicalTrials.gov (clinical registration number: NCT03202823).PMID:37710315 | DOI:10.1186/s12933-023-01979-1
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Louise M énégaut Aline Laubriet Valentin Crespy Damien Leleu Thomas Pilot Kevin Van Dongen Jean-Paul Pais de Barros Thomas Gautier Jean-Michel Petit Charles Thomas Maxime Nguyen Eric Steinmetz David Masson Source Type: research
New Targets in Atherosclerosis: Vascular Smooth Muscle Cell Plasticity and Macrophage Polarity
Clin Ther. 2023 Sep 12:S0149-2918(23)00319-3. doi: 10.1016/j.clinthera.2023.08.015. Online ahead of print.ABSTRACTPURPOSE: Despite an increase in treatment options, and substantial reductions in cardiovascular mortality over the past half-century, atherosclerosis remains the most prevalent cause of premature mortality worldwide. The development of innovative new therapies is crucial to further minimize atherosclerosis-related deaths. The diverse array of cell phenotypes derived from vascular smooth muscle cells (SMCs) and macrophages within atherosclerotic plaques are increasingly becoming recognized for their beneficial a...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Michael Hutton Madeleine Frazer Alexander Lin Sanjay Patel Ashish Misra Source Type: research
Early Computed Tomography Coronary Angiography and Preventative Treatment in Patients with Suspected Acute Coronary Syndrome A secondary analysis of the RAPID-CTCA trial
CONCLUSIONS: Prescription patterns of preventative treatment varied during index hospitalisation in patients with suspected acute coronary syndrome. Early CTCA facilitated targeted individualisation of these therapies based on the extent of coronary artery disease.PMID:37709109 | DOI:10.1016/j.ahj.2023.09.003
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Kang-Ling Wang Mohammed N Meah Anda Bularga Katherine Oatey Rachel O'Brien Jason E Smith Nick Curzen Attila Kardos Liza Keating Dirk Felmeden Robert F Storey Steve Goodacre Carl Roobottom David E Newby Alasdair J Gray RAPID-CTCA Investigators Source Type: research
AEE alleviates ox-LDL-induced lipid accumulation and inflammation in macrophages
Biomed Pharmacother. 2023 Sep 12;167:115486. doi: 10.1016/j.biopha.2023.115486. Online ahead of print.ABSTRACTAtherosclerosis is a chronic immune inflammatory disease. Aspirin eugenol ester (AEE) is a novel safe and non-toxic compound with many pharmacological effects such as anti-inflammatory, anti-hyperlipidemic and anti-thrombotic action. In order to investigate the effect of AEE on the inhibition of aortic lipid plaque formation and macrophage-derived foam cell formation induced by oxidized low density lipoprotein (ox-LDL), in vivo atherosclerosis model by feeding ApoE-/- mice with a high-fat diet and foam cells format...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ya-Xian Liu Xi-Wang Liu Ya-Jun Yang Shi-Hong Li Li-Xia Bai Wen-Bo Ge Xiao Xu Cun Li Jian-Yong Li Zhe Qin Source Type: research
In silico analysis and verification of critical genes related to vascular calcification in multiple diseases
This study identified promising molecular targets for VC therapy.PMID:37707349 | DOI:10.1002/cbf.3858
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Shicheng Li Jiangwen Ruan Zicong Yang Ling Liu Tongmeng Jiang Source Type: research
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
