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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Anti-leishmanial and cytotoxic compounds isolated from marine sponge < em > Hemimycale sp < /em >
Nat Prod Res. 2023 Sep 10:1-7. doi: 10.1080/14786419.2023.2256448. Online ahead of print.ABSTRACTThe methanolic extract of the marine sponge Hemimycale sp. yielded two new compounds; 1-(2'-methyl heptadecyl) phenol (1) and a new pyrazole derivative; 4-(hydroxymethyl)-1H-pyrazol-3-ol (2), together with previously isolated (2'R)-2'-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxy-16-methylpentadecan-2-yl)docosanamide (3), cholesterol (4), 5, 8-epi-dioxycholest-6-en-3-ol (5) and 3-acetylsesterstatin 3 (6), which were firstly reported from family Hymedesmiidae. Their structure elucidation was based on extensive nuclear magnetic resonanc...
Source: Natural Product Research - September 10, 2023 Category: Biochemistry Authors: Asmaa Abo Elgoud Said Eman Zekry Attia Amira S Wanas Mamdouh Nabil Samy Usama Ramadan Abdelmohsen Katsuyoshi Matsunami Mostafa A Fouad Source Type: research
Upregulation of NOR-1 in calcified human vascular tissues: impact on osteogenic differentiation and calcification
Transl Res. 2023 Sep 8:S1931-5244(23)00144-5. doi: 10.1016/j.trsl.2023.09.004. Online ahead of print.ABSTRACTCardiovascular calcification is a significant public health issue whose pathophysiology is not fully understood. NOR-1 regulates critical processes in cardiovascular remodeling, but its contribution to ectopic calcification is unknown. NOR-1 was overexpressed in human calcific aortic valves and calcified atherosclerotic lesions colocalizing with RUNX2, a factor essential for osteochondrogenic differentiation and calcification. NOR-1 and osteogenic markers were upregulated in calcifying human valvular interstitial ce...
Source: Translational Research : the journal of laboratory and clinical medicine - September 10, 2023 Category: Laboratory Medicine Authors: Carme Ballester-Servera Laia Ca ñes Judith Alonso Lidia Puertas-Umbert Paula V ázquez-Sufuentes Manel Taur ón Elena Rosell ó-Díez Francisco Mar ín Cristina Rodr íguez Jos é Martínez-González Source Type: research
Anti-leishmanial and cytotoxic compounds isolated from marine sponge < em > Hemimycale sp < /em >
Nat Prod Res. 2023 Sep 10:1-7. doi: 10.1080/14786419.2023.2256448. Online ahead of print.ABSTRACTThe methanolic extract of the marine sponge Hemimycale sp. yielded two new compounds; 1-(2'-methyl heptadecyl) phenol (1) and a new pyrazole derivative; 4-(hydroxymethyl)-1H-pyrazol-3-ol (2), together with previously isolated (2'R)-2'-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxy-16-methylpentadecan-2-yl)docosanamide (3), cholesterol (4), 5, 8-epi-dioxycholest-6-en-3-ol (5) and 3-acetylsesterstatin 3 (6), which were firstly reported from family Hymedesmiidae. Their structure elucidation was based on extensive nuclear magnetic resonanc...
Source: Natural Product Research - September 10, 2023 Category: Biochemistry Authors: Asmaa Abo Elgoud Said Eman Zekry Attia Amira S Wanas Mamdouh Nabil Samy Usama Ramadan Abdelmohsen Katsuyoshi Matsunami Mostafa A Fouad Source Type: research
The Effectiveness of Medical Nutrition Therapy Provided by a Dietitian in Adults with Prediabetes: A Systematic Review and Meta-Analysis
CONCLUSIONS: MNT plays a key role in improving cardiometabolic risk factors in adults with prediabetes.REGISTRATION ID AND URL: ID #351421; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=351421.PMID:37689140 | DOI:10.1016/j.ajcnut.2023.08.022
Source: The American Journal of Clinical Nutrition - September 9, 2023 Category: Nutrition Authors: Josephine M Dudzik Katelyn E Senkus Alison B Evert Hollie A Raynor Mary R Rozga Deepa Handu Lisa M Moloney Source Type: research
The Role of Endoplasmic Reticulum in Lipotoxicity during MASLD Pathogenesis
Am J Pathol. 2023 Sep 7:S0002-9440(23)00314-0. doi: 10.1016/j.ajpath.2023.08.007. Online ahead of print.ABSTRACTPerturbations in lipid and protein homeostasis induce endoplasmic reticulum (ER) stress in metabolic-dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). Lipotoxic and proteotoxic stress can activate the unfolded protein response (UPR) transducers: Inositol Requiring Enzyme1α, PKR-like ER Kinase and Activating Transcription Factor 6α. Collectively, these pathways induce expression of genes that encode functions to resolve the protein folding defect ...
Source: Am J Pathol - September 9, 2023 Category: Pathology Authors: Nanditha Venkatesan Luke C Doskey Harmeet Malhi Source Type: research
Multivessel Coronary Artery Disease Complicated by Diabetes Mellitus Has a Relatively Small Effect on Endothelial and Lipoprotein Lipases Expression in the Human Atrial Myocardium and Coronary Perivascular Adipose Tissue
Int J Mol Sci. 2023 Aug 31;24(17):13552. doi: 10.3390/ijms241713552.ABSTRACTEndothelial (EL) and lipoprotein (LPL) lipases are enzymes involved in lipoproteins metabolism and formation of atherosclerosis, a pathological feature of coronary artery disease (CAD). This paper examines the role of the lipases in the right atrial appendage (RAA) and coronary perivascular adipose tissue (PVAT) of patients with CAD alone or with accompanying diabetes. Additionally, correlation analysis for plasma concentration of the lipases, apolipoproteins (ApoA-ApoJ) and blood lipids (Chol, HDL-C, LDL-C, TAG) was performed. We observed that CAD...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Ma łgorzata Knapp Bart łomiej Łukaszuk Anna Lisowska Tomasz Hirnle Jan G órski Adrian Chabowski Agnieszka Mik łosz Source Type: research
Sex Differences in Glomerular Lesions, in Atherosclerosis Progression, and in the Response to Angiotensin-Converting Enzyme Inhibitors in the ApoE < sup > -/- < /sup > Mice Model
This study analyzes sex-based differences in renal structure and the response to the Angiotensin-Converting Enzyme (ACE) inhibitor enalapril in a mouse model of atherosclerosis. Eight weeks old ApoE-/- mice received enalapril (5 mg/kg/day, subcutaneous) or PBS (control) for an additional 14 weeks. Each group consisted of six males and six females. Females exhibited elevated LDL-cholesterol levels, while males presented higher creatinine levels and proteinuria. Enalapril effectively reduced blood pressure in both groups, but proteinuria decreased significantly only in females. Plaque size analysis and assessment of kidney i...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Adri án Mallén Ronny Rodriguez-Urquia Rafael Alvarez Eduard Dorca-Duch Estanis Navarro Miguel Hueso Source Type: research
Therapeutic Aspects of < em > Prunus cerasus < /em > Extract in a Rabbit Model of Atherosclerosis-Associated Diastolic Dysfunction
This study evaluates the potential therapeutic effects of anthocyanin-rich Prunus cerasus (sour cherry) extract (PCE) on atherosclerosis-associated cardiac dysfunction, described by the impairment of the NO-PKG (nitric oxide-protein kinase G) pathway and the antioxidant capacity. Initially, a rabbit model of atherosclerotic cardiovascular disease was established by administering a cholesterol-rich diet, enabling the examination of the impact of 9 g/kg PCE on the pre-existing compromised cardiovascular condition. After that, the animals were divided into four groups for 12 weeks: the (1) untreated control group; (2) PCE-adm...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Reka Szekeres Daniel Priksz Rita Kiss Dana Diana Romanescu Mariann Bombicz Balazs Varga Rudolf Gesztelyi Anna Szilagyi Barbara Takacs Vera Tarjanyi Beata Pelles-Tasko Ildiko Forgacs Judit Remenyik Zoltan Szilvassy Bela Juhasz Source Type: research
Use of Apolipoprotein B in the Era of Precision Medicine: Time for a Paradigm Change?
J Clin Med. 2023 Sep 3;12(17):5737. doi: 10.3390/jcm12175737.ABSTRACTAtherosclerotic cardiovascular disease (ASCVD) remains the leading cause of death worldwide and the risk of a major cardiovascular event is highest among those with established disease. Ongoing management of these patients relies on the accurate assessment of their response to any prescribed therapy, and their residual risk, in order to optimize treatment. Recent international guidelines and position statements concur that the plasma concentration of apolipoprotein B (apoB) is the most accurate measure of lipoprotein associated ASCVD risk. This is especia...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Justine Cole Rafael Zubir án Anna Wolska Ishwarlal Jialal Alan T Remaley Source Type: research
Aortic Wall Thickness as a Surrogate for Subclinical Atherosclerosis in Familial and Nonfamilial Hypercholesterolemia: Quantitative 3D Magnetic Resonance Imaging Study and Interrelations with Computed Tomography Calcium Scores, and Carotid Ultrasonography
J Clin Med. 2023 Aug 27;12(17):5589. doi: 10.3390/jcm12175589.ABSTRACTWe aimed to compare the extent of subclinical atherosclerosis in the ascending and descending aortas by measuring wall area and thickness using 3D cardiovascular magnetic resonance imaging (aAWAI and dAWAI) in patients with asymptomatic familial hypercholesterolemia (FH) and nonfamilial hypercholesterolemia (NFH). We also aimed to establish the interrelations of CMR parameters with other subclinical atherosclerosis measurements, such as calcium scores, obtained using computed tomography in coronary arteries (CCS) and ascending and descending aorta (TCSas...
Source: Atherosclerosis - September 9, 2023 Category: Cardiology Authors: Rafa ł Gałąska Dorota Kulawiak-Ga łąska Karolina Dorniak Aneta Str óżyk Agnieszka Sabisz Magdalena Chmara Bartosz Was ąg Agnieszka Mickiewicz Andrzej Rynkiewicz Marcin Fija łkowski Marcin Grucha ła Source Type: research
