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Total 20241 results found since Jan 2013.

Management in primary health care: discourses about the search for respiratory symptomatics of tuberculosis
ABSTRACT The study aimed to analyze the discourse of Primary Health Care managers about the search for respiratory symptomatics as an epidemiological surveillance action of tuberculosis. A qualitative study was undertaken, guided by the theoretical and analytical framework of French Discourse Analysis. Data were produced in May 2012 through semi-structured interviews with 14 subjects. Two discursive blocks were produced: marks of power in the execution of the search for respiratory symptomatics; resistance strategies in the search for respiratory symptomatics. Discursive positions were grounded in the traditional managemen...
Source: Texto e Contexto - Enfermagem - October 3, 2016 Category: Global & Universal Source Type: research

WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Publication date: Available online 19 September 2014 Source:International Journal for Parasitology: Drugs and Drug Resistance Author(s): Roopa Ramamoorthi , Katy M. Graef , Jennifer Dent Neglected tropical diseases (NTDs), malaria, and tuberculosis have a devastating effect on an estimated 1.6billion people worldwide. The World Intellectual Property Organization (WIPO) Re:Search consortium accelerates the development of new drugs, vaccines, and diagnostics for these diseases by connecting the assets and resources of pharmaceutical companies, such as compound libraries and expertise, to academic or nonprofit researchers w...
Source: International Journal for Parasitology: Drugs and Drug Resistance - October 12, 2014 Category: Parasitology Source Type: research

The Diverse Search for Synthetic, Semisynthetic and Natural Product Antibiotics From the 1940s and Up to 1960 Exemplified by a Small Pharmaceutical Player
The 1940s and 1950s witnessed a diverse search for not just natural product antibiotics but also for synthetic and semisynthetic compounds. This review revisits this epoch, using the research by a Danish pharmaceutical company, LEO Pharma, as an example. LEO adopted a strategy searching for synthetic antibiotics toward specific bacterial pathogens, in particular Mycobacterium tuberculosis, leading to the discovery of a new derivative of a known drug. Work on penicillin during and after WWII lead to the development of associated salts/esters and a search for new natural product antibiotics. This led initially to no new, mar...
Source: Frontiers in Microbiology - June 11, 2020 Category: Microbiology Source Type: research

EDITORIAL:New Developments In The Search For Agents To Treat Tuberculosis.
PMID: 24111910 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - October 10, 2013 Category: Chemistry Authors: Boechat N Tags: Curr Top Med Chem Source Type: research

Gene cooption in Mycobacteria and search for virulence attributes: Comparative proteomic analyses of Mycobacterium tuberculosis, Mycobacterium indicus pranii and other mycobacteria.
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a leading infectious disease taking one human life every 15s globally. Mycobacterium undergoes reductive evolution; the ancestors have bigger genome size and rich in metabolic pathways. Mycobacterium indicus pranii (MIP) is placed much above Mycobacterium tuberculosis (M.tb) in evolutionary scale and is a non-pathogenic, saprophytic mycobacterium. Our in silico comparative proteomic analyses of virulence factors of M.tb and their homologs in 12 different Mycobacterial species, including MIP, point toward gene cooption as an important mechanism in...
Source: International Journal of Medical Microbiology - May 29, 2014 Category: Microbiology Authors: Singh Y, Kohli S, Sowpati DT, Rahman SA, Tyagi AK, Hasnain SE Tags: Int J Med Microbiol Source Type: research

The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
Treatment for tuberculosis is effective with the use of proper antibiotics, but the number of drug-resistant cases is increasing. Drug resistance occurred in 650,000 cases of the 20 million patients in treatment worldwide in 2011, which demonstrates the necessity of finding new therapeutic approaches. In this context, the search for new medicines and immunomodulators could help reduce the prevalence and incidence of multi-drug-resistant tuberculosis cases. Thus several preclinical studies demonstrate the involvement of the P2X7 receptor (P2X7R) in the control of Mycobacterium tuberculosis (MTB) infection. Adenosine triphos...
Source: Cellular Physiology and Biochemistry - August 28, 2015 Category: Cytology Source Type: research

Significance of immune response to Mycobacterium tuberculosis culture filtrate protein antigens in cerebrospinal fluid of tuberculous meningitis patients: A search for diagnostic marker.
Authors: Giribhattanavar P, Kumar K, Raajasekar S, Chandrashekar N, Patil S Abstract Mycobacterium tuberculosis (H37Ra) culture filtrate proteins (CFP) are explored as a diagnostic marker for tuberculous meningitis (TBM). Cerebrospinal fluid (CSF) samples from patients were categorized as confirmed (n=47), suspected (n=20) and non-TBM (n=25) cases. Immune response by western-blot revealed TBM CSF samples are having heterogeneous response to CFP. CFP ELISA was 92% sensitive and 38.30% specific. ODs of confirmed TBM and non-TBM cases were significantly different (P<0.0001) and also the suspected TBM and non-TBM ca...
Source: Journal of Immunoassay and Immunochemistry - July 28, 2016 Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research

Evaluation of the benefit of different complementary exams in the search for a TB diagnosis algorithm for HIV patients put on ART in Niamey, Niger.
The objective of this research is to evaluate the performance and the cost-effectiveness of various paraclinical testing strategies of TB among adult patients with HIV, using available tests in routine for patients cared in Niamey. This is a multicentric prospective intervention study performed in Niamey between 2010 and 2013. TB screening has been sought in newly diagnosed PLHIV, before ART treatment, performing consistently: a sputum examination by MZN (Ziehl-Nielsen staining) and microscopy fluorescence (MIF), chest radiography (CR), and abdominal ultrasound. The performance of these different tests was calculated using...
Source: Bulletin de la Societe de Pathologie Exotique - November 18, 2016 Category: Tropical Medicine Tags: Bull Soc Pathol Exot Source Type: research

Identification of beta-Lactamases and beta-Lactam-Related Proteins in Human Pathogenic Bacteria using a Computational Search Approach.
In this report, we searched for the presence of beta-lactam-related proteins in 591 bacterial proteomes belonging to 52 species that are pathogenic to humans. The amino acid sequences for 19 different types of beta-lactamases (ACT, CARB, CifA, CMY, CTX, FOX, GES, GOB, IMP, IND, KPC, LEN, OKP, OXA, OXY, SHV, TEM, NDM, and VIM) were obtained from the ARG-ANNOT database and were used to construct 19 HMM profiles, which were used to identify potential beta-lactamases in the completely sequenced bacterial proteomes. A total of 2877 matches that included the word "beta-lactamase" and/or "penicillin" in the functional annotation ...
Source: Current Microbiology - May 16, 2017 Category: Microbiology Authors: Brambila-Tapia AJL, Perez-Rueda E, Barrios H, Dávalos-Rodríguez NO, Dávalos-Rodríguez IP, Cardona-Muñoz EG, Salazar-Páramo M Tags: Curr Microbiol Source Type: research

Barriers to treatment adherence for individuals with latent tuberculosis infection: A systematic search and narrative synthesis of the literature
ConclusionTo further improve treatment and LTBI control and to fulfill the World Health Organization goal of eliminating TB in low‐incidence countries, greater priority should be given to the use of treatment regimens involving shorter durations and fewer adverse effects, like the 3‐month regimen of weekly rifapentine plus isoniazid, supported by innovative patient education and incentive strategies.
Source: The International Journal of Health Planning and Management - October 1, 2017 Category: Health Management Authors: Yisi Liu, Stephen Birch, K. Bruce Newbold, Beverley M. Essue Tags: REVIEW Source Type: research

Secret-AAR: A web server to assess the antigenic density of proteins and homology search against bacterial and parasite secretome proteins.
Abstract The secretome refers to all the Excreted/Secreted (ES) proteins, and these are involved in critical biological processes, such as cell-cell communication, and host immune response. Recently, we introduced the abundance of antigenic regions (AAR) value to assess the protein antigenic density and to evaluate the antigenic potential of secretomes. Here, to facilitate the AAR calculation, we implemented it as a user-friendly webserver. We extended the webserver capabilities implementing a sequence-based tool for searching homologous proteins across secretomes, including experimental and predicted secretomes o...
Source: Genomics - October 11, 2018 Category: Genetics & Stem Cells Authors: Cornejo-Granados F, Hurtado-Ramírez JM, Hernández-Pando R, Ochoa-Leyva A Tags: Genomics Source Type: research

Malaria and tuberculosis as diseases of neglected populations: state of the art in chemotherapy and advances in the search for new drugs.
Abstract Malaria and tuberculosis are no longer considered to be neglected diseases by the World Health Organization. However, both are huge challenges and public health problems in the world, which affect poor people, today referred to as neglected populations. In addition, malaria and tuberculosis present the same difficulties regarding the treatment, such as toxicity and the microbial resistance. The increase of Plasmodium resistance to the available drugs along with the insurgence of multidrug- and particularly tuberculosis drug-resistant strains are enough to justify efforts towards the development of novel m...
Source: Memorias do Instituto Oswaldo Cruz - October 20, 2020 Category: Infectious Diseases Authors: de Araújo RV, Santos SS, Sanches LM, Giarolla J, El Seoud O, Ferreira EI Tags: Mem Inst Oswaldo Cruz Source Type: research

Strategies employed to evade the host immune response and the mechanism of drug resistance in Mycobacterium tuberculosis: In search of finding new targets
This article provides an in-depth and critical analysis of various strategies employed by the drug-resistant M. tuberculosis to escape the host immune response, as a result of which this bacterium persists in the host for a longer period of time and leads to the development of tuberculosis infection. Furthermore, we also discussed the new targets for the effective treatment of drug resistant tuberculosis.PMID:34951359 | DOI:10.2174/1389201023666211222164938
Source: Current Pharmaceutical Biotechnology - December 24, 2021 Category: Biotechnology Authors: Bashir Ahmed Sheikh Basharat A Bhat Zahoor Ahmad Manzoor A Mir Source Type: research